Search Results - "Catanzaro, Nicholas"

A nano-luciferase expressing human coronavirus OC43 for countermeasure development by Diefenbacher, Meghan V., Baric, Thomas J., Martinez, David R., Baric, Ralph S., Catanzaro, Nicholas J., Sheahan, Timothy P.

“…•Recovery of a HCoV-OC43 reporter virus expressing nanoluciferase.•Replication of HCoV-OC43 is enhanced in IFITM3 expressing Huh7.5 cells.•FDA-approved…”
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Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology by Philip, Drake T, Goins, Nigel M, Catanzaro, Nicholas J, Misumi, Ichiro, Whitmire, Jason K, Atkins, Hannah M, Lazear, Helen M

“…Type III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been best characterized in respiratory and gastrointestinal infections, but…”
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Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements by Snouwaert, John N, Jania, Leigh A, Nguyen, Trang, Martinez, David R, Schäfer, Alexandra, Catanzaro, Nicholas J, Gully, Kendra L, Baric, Ralph S, Heise, Mark, Ferris, Martin T, Anderson, Elizabeth, Pressey, Katia, Dillard, Jacob A, Taft-Benz, Sharon, Baxter, Victoria K, Ting, Jenny P-Y, Koller, Beverly H

“…Angiotensin-converting enzyme 2 (ACE2), part of the renin-angiotensin system (RAS), serves as an entry point for SARS-CoV-2, leading to viral proliferation in…”
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Pig model mimicking chronic hepatitis E virus infection in immunocompromised patients to assess immune correlates during chronicity by Cao, Dianjun, Cao, Qian M., Subramaniam, Sakthivel, Yugo, Danielle M., Heffron, C. Lynn, Rogers, Adam J., Kenney, Scott P., Tian, Debin, Matzinger, Shannon R., Overend, Christopher, Catanzaro, Nicholas, LeRoith, Tanya, Wang, Heng, Piñeyro, Pablo, Lindstrom, Nicole, Clark-Deener, Sherrie, Yuan, Lijuan, Meng, Xiang-Jin

“…Chronic hepatitis E virus (HEV) infection is a significant clinical problem in immunocompromised individuals such as organ transplant recipients, although the…”
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Engineered immunogens to elicit antibodies against conserved coronavirus epitopes by Kapingidza, A. Brenda, Marston, Daniel J., Harris, Caitlin, Wrapp, Daniel, Winters, Kaitlyn, Mielke, Dieter, Xiaozhi, Lu, Yin, Qi, Foulger, Andrew, Parks, Rob, Barr, Maggie, Newman, Amanda, Schäfer, Alexandra, Eaton, Amanda, Flores, Justine Mae, Harner, Austin, Catanzaro, Nicholas J., Mallory, Michael L., Mattocks, Melissa D., Beverly, Christopher, Rhodes, Brianna, Mansouri, Katayoun, Van Itallie, Elizabeth, Vure, Pranay, Dunn, Brooke, Keyes, Taylor, Stanfield-Oakley, Sherry, Woods, Christopher W., Petzold, Elizabeth A., Walter, Emmanuel B., Wiehe, Kevin, Edwards, Robert J., Montefiori, David C., Ferrari, Guido, Baric, Ralph, Cain, Derek W., Saunders, Kevin O., Haynes, Barton F., Azoitei, Mihai L.

“…Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike protein, which continually mutates to escape acquired immunity. Other…”
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Multiplexing mRNAs builds a "broad-immunity wall" against the flu by Catanzaro, Nicholas J, Martinez, David R

“…Delivery of mRNAs encoding influenza HA antigens covering all known subtypes and lineages elicits cross-reactive and protective immunity…”
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Vaccine-mediated protection against Merbecovirus and Sarbecovirus challenge in mice by Martinez, David R., Schäfer, Alexandra, Gavitt, Tyler D., Mallory, Michael L., Lee, Esther, Catanzaro, Nicholas J., Chen, Haiyan, Gully, Kendra, Scobey, Trevor, Korategere, Pooja, Brown, Alecia, Smith, Lena, Parks, Robert, Barr, Maggie, Newman, Amanda, Bowman, Cindy, Powers, John M., Soderblom, Erik J., Mansouri, Katayoun, Edwards, Robert J., Baric, Ralph S., Haynes, Barton F., Saunders, Kevin O.

“…The emergence of three highly pathogenic human coronaviruses—severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003, Middle Eastern respiratory…”
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The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses by Martinez, David R, Moreira, Fernando R, Catanzaro, Nicholas J, Diefenbacher, Meghan V, Zweigart, Mark R, Gully, Kendra L, De la Cruz, Gabriela, Brown, Ariane J, Adams, Lily E, Yount, Boyd, Baric, Thomas J, Mallory, Michael L, Conrad, Helen, May, Samantha R, Dong, Stephanie, Scobey, D Trevor, Nguyen, Cameron, Montgomery, Stephanie A, Perry, Jason K, Babusis, Darius, Barrett, Kimberly T, Nguyen, Anh-Hoa, Nguyen, Anh-Quan, Kalla, Rao, Bannister, Roy, Feng, Joy Y, Cihlar, Tomas, Baric, Ralph S, Mackman, Richard L, Bilello, John P, Schäfer, Alexandra, Sheahan, Timothy P

“…Despite the wide availability of several safe and effective vaccines that prevent severe COVID-19, the persistent emergence of severe acute respiratory…”
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Host Pah1p phosphatidate phosphatase limits viral replication by regulating phospholipid synthesis by Zhang, Zhenlu, He, Guijuan, Han, Gil-Soo, Zhang, Jiantao, Catanzaro, Nicholas, Diaz, Arturo, Wu, Zujian, Carman, George M, Xie, Lianhui, Wang, Xiaofeng

“…Replication of positive-strand RNA viruses [(+)RNA viruses] takes place in membrane-bound viral replication complexes (VRCs). Formation of VRCs requires…”
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Mapping of susceptibility loci for Ebola virus pathogenesis in mice by Schäfer, Alexandra, Marzi, Andrea, Furuyama, Wakako, Catanzaro, Nicholas J., Nguyen, Cameron, Haddock, Elaine, Feldmann, Friederike, Meade-White, Kimberly, Thomas, Tina, Hubbard, Miranda L., Gully, Kendra L., Leist, Sarah R., Hock, Pablo, Bell, Timothy A., De la Cruz, Gabriela E., Midkiff, Bentley R., Martinez, David R., Shaw, Ginger D., Miller, Darla R., Vernon, Michael J., Graham, Rachel L., Cowley, Dale O., Montgomery, Stephanie A., Schughart, Klaus, de Villena, Fernando Pardo Manuel, Wilkerson, Gregory K., Ferris, Martin T., Feldmann, Heinz, Baric, Ralph S.

“…Ebola virus (EBOV), a major global health concern, causes severe, often fatal EBOV disease (EVD) in humans. Host genetic variation plays a critical role, yet…”
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Host range, transmissibility and antigenicity of a pangolin coronavirus by Hou, Yixuan J., Chiba, Shiho, Leist, Sarah R., Meganck, Rita M., Martinez, David R., Schäfer, Alexandra, Catanzaro, Nicholas J., Sontake, Vishwaraj, West, Ande, Edwards, Catlin E., Yount, Boyd, Lee, Rhianna E., Gallant, Samuel C., Zost, Seth J., Powers, John, Adams, Lily, Kong, Edgar F., Mattocks, Melissa, Tata, Aleksandra, Randell, Scott H., Tata, Purushothama R., Halfmann, Peter, Crowe, James E., Kawaoka, Yoshihiro, Baric, Ralph S.

“…The pathogenic and cross-species transmission potential of SARS-CoV-2-related coronaviruses (CoVs) remain poorly characterized. Here we recovered a wild-type…”
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An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo by Zhou, Nian E., Tang, Su, Bian, Xuelin, Parai, Maloy K., Krieger, Inna V., Flores, Armando, Jaiswal, Pradeep K., Bam, Radha, Wood, Jeremy L., Shi, Zhe, Stevens, Laura J., Scobey, Trevor, Diefenbacher, Meghan V., Moreira, Fernando R., Baric, Thomas J., Acharya, Arjun, Shin, Joonyoung, Rathi, Manish M., Wolff, Karen C., Riva, Laura, Bakowski, Malina A., McNamara, Case W., Catanzaro, Nicholas J., Graham, Rachel L., Schultz, David C., Cherry, Sara, Kawaoka, Yoshihiro, Halfmann, Peter J., Baric, Ralph S., Denison, Mark R., Sheahan, Timothy P., Sacchettini, James C.

“…Safe, effective, and low-cost oral antiviral therapies are needed to treat those at high risk for developing severe COVID-19. To that end, we performed a…”
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Comparing the Efficacy of Targeted and Blast Portal Messaging in Message Opening Rate and Anticoagulation Initiation in Patients With Atrial Fibrillation in the Preventing Preventable Strokes Study II: Prospective Cohort Study by Kapoor, Alok, Patel, Parth, Chennupati, Soumya, Mbusa, Daniel, Sadiq, Hammad, Rampam, Sanjeev, Leung, Robert, Miller, Megan, Vargas, Kevin Rivera, Fry, Patrick, Lowe, Mary Martin, Catalano, Christina, Harrison, Charles, Catanzaro, John Nicholas, Crawford, Sybil, Smith, Anne Marie

“…The gap in anticoagulation use among patients with atrial fibrillation (AF) is a major public health threat. Inadequate patient education contributes to this…”
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Induction of the unfolded protein response (UPR) suppresses porcine reproductive and respiratory syndrome virus (PRRSV) replication by Catanzaro, Nicholas, Meng, Xiang-Jin

“…•PRRSV induces UPR through all 3 signaling branches, including PERK, IRE1a and ATF6.•Induction of UPR significantly suppresses PRRSV replication and RNA…”
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Porcine reproductive and respiratory syndrome virus (PRRSV)-induced stress granules are associated with viral replication complexes and suppression of host translation by Catanzaro, Nicholas, Meng, Xiang-Jin

“…•PRRSV induces the formation of bona fide stress granules (SGs) at late time points post-infection.•PRRSV-induced SGs are closely associated with VRCs, yet not…”
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Structurally Conserved Domains between Flavivirus and Alphavirus Fusion Glycoproteins Contribute to Replication and Infectious-Virion Production by Rangel, Margarita V, Catanzaro, Nicholas, Thannickal, Sara A, Crotty, Kelly A, Noval, Maria G, Johnson, Katherine E E, Ghedin, Elodie, Lazear, Helen M, Stapleford, Kenneth A

“…Alphaviruses and flaviviruses have class II fusion glycoproteins that are essential for virion assembly and infectivity. Importantly, the tip of domain II is…”
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Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice by Brown, Ariane J, Won, John J, Wolfisberg, Raphael, Fahnøe, Ulrik, Catanzaro, Nicholas, West, Ande, Moreira, Fernando R, Nogueira Batista, Mariana, Ferris, Martin T, Linnertz, Colton L, Leist, Sarah R, Nguyen, Cameron, De la Cruz, Gabriela, Midkiff, Bentley R, Xia, Yongjuan, Evangelista, Mia D, Montgomery, Stephanie A, Billerbeck, Eva, Bukh, Jens, Scheel, Troels K H, Rice, Charles M, Sheahan, Timothy P

“…Human genetic variation is thought to guide the outcome of HCV infection, but model systems within which to dissect these host genetic mechanisms are limited…”
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A chimeric virus created by DNA shuffling of the capsid genes of different subtypes of porcine circovirus type 2 (PCV2) in the backbone of the non-pathogenic PCV1 induces protective immunity against the predominant PCV2b and the emerging PCV2d in pigs by Matzinger, Shannon R, Opriessnig, Tanja, Xiao, Chao-Ting, Catanzaro, Nicholas, Beach, Nathan M, Slade, David E, Nitzel, Gregory P, Meng, Xiang-Jin

“…Abstract Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-associated disease (PCVAD). Available commercial vaccines all…”
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Recombinant Porcine Reproductive and Respiratory Syndrome Virus Expressing Membrane-Bound Interleukin-15 as an Immunomodulatory Adjuvant Enhances NK and γδ T Cell Responses and Confers Heterologous Protection by Cao, Qian M, Ni, Yan-Yan, Cao, Dianjun, Tian, Debin, Yugo, Danielle M, Heffron, C Lynn, Overend, Christopher, Subramaniam, Sakthivel, Rogers, Adam J, Catanzaro, Nicholas, LeRoith, Tanya, Roberts, Paul C, Meng, Xiang-Jin

“…Cytokines are often used as adjuvants to improve vaccine immunogenicity, since they are important in initiating and shaping the immune response. The available…”
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Efficient priming of CD4 T cells by Langerin-expressing dendritic cells targeted with porcine epidemic diarrhea virus spike protein domains in pigs by Subramaniam, Sakthivel, Cao, Dianjun, Tian, Debin, Cao, Qian M., Overend, Christopher, Yugo, Danielle M., Matzinger, Shannon R., Rogers, Adam J., Heffron, C. Lynn, Catanzaro, Nicholas, Kenney, Scott P., Opriessnig, Tanja, Huang, Yao-Wei, Labarque, Geoffrey, Wu, Stephen Q., Meng, Xiang-Jin

“…•Targeting PEDV spike protein domains to Langerin-expressing dendritic cells through a single chain antibody.•Transdermal Langerin-targeting of PEDV S antigen…”
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