Search Results - "Castro Júnior, Célio José de"

Ion Channels-related Neuroprotection and Analgesia Mediated by Spider Venom Peptides by Nogueira Souza, Ana Caroline, Binda, Nancy Scardua, Almeida, Huemara Yuri, de Castro Júnior, Célio José, Gomez, Marcus Vinicius, Ribeiro, Fabíola Mara, Da Silva, Juliana Figueira

“…Ion channels play critical roles in generating and propagating action potentials and in neurotransmitter release at a subset of excitatory and inhibitory…”
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Analgesic effects of Phα1β toxin: a review of mechanisms of action involving pain pathways by Silva, Juliana Figueira da, Binda, Nancy Scardua, Pereira, Elizete Maria Rita, Lavor, Mário Sérgio Lima de, Vieira, Luciene Bruno, Souza, Alessandra Hubner de, Rigo, Flávia Karine, Ferrer, Hèlia Tenza, Castro Júnior, Célio José de, Ferreira, Juliano, Gomez, Marcus Vinicius

“…Phα1β is a neurotoxin purified from spider venom that acts as a high-voltage-activated (HVA) calcium channel blocker. This spider peptide has shown a high…”
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Mechanisms involved in the nociception triggered by the venom of the armed spider Phoneutria nigriventer by Gewehr, Camila, Oliveira, Sara Marchesan, Rossato, Mateus Fortes, Trevisan, Gabriela, Dalmolin, Gerusa Duarte, Rigo, Flávia Karine, de Castro Júnior, Célio José, Cordeiro, Marta Nascimento, Ferreira, Juliano, Gomez, Marcus V

“…The frequency of accidental spider bites in Brazil is growing, and poisoning due to bites from the spider genus Phoneutria nigriventer is the second most…”
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Analgesic and side effects of intravenous recombinant Phα1β by Rigo, Flavia Karine, Rossato, Mateus Fortes, Borges, Vanessa, da Silva, Juliana Figueira, Pereira, Elizete Maria Rita, de Ávila, Ricardo Andrez Machado, Trevisan, Gabriela, Dos Santos, Duana Carvalho, Diniz, Danuza Montijo, Silva, Marco Aurélio Romano, de Castro, Célio José, Cunha, Thiago Mattar, Ferreira, Juliano, Gomez, Marcus Vinicius

“…Intrathecal injection of voltage-sensitive calcium channel blocker peptide toxins exerts analgesic effect in several animal models of pain. Upon intrathecal…”
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Critical Pronociceptive Role of Family 2 Voltage-Gated Calcium Channels in a Novel Mouse Model of HIV-Associated Sensory Neuropathy by Lückemeyer, Debora Denardin, Prudente, Arthur Silveira, de Amorim Ferreira, Marcella, da Silva, Ana Merian, Tonello, Raquel, Junior, Sérgio José Macedo, do Prado, Camila Sant’ Helena, de Castro Júnior, Célio José, Gomez, Marcus Vinicius, Calixto, João Batista, Ferreira, Juliano

“…Some people living with HIV present painful sensory neuropathy (HIV-SN) that is pharmacoresistant, sex-associated, and a major source of morbidity. Since the…”
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The Effect of Spider Toxin PhTx3-4, ω-Conotoxins MVIIA and MVIIC on Glutamate Uptake and on Capsaicin-Induced Glutamate Release and [Ca2+]i in Spinal cord Synaptosomes by Gonçaves, Jomara M., Ferreira, Juliano, Prado, Marco Antonio M., Cordeiro, Marta N., Richardson, Michael, do Nascimento Pinheiro, Ana Cristina, Romano Silva, Marco A., de Castro Junior, Celio José, Souza, Alessandra H., Gomez, Marcus Vinicius

“…In spinal cord synaptosomes, the spider toxin PhTx3-4 inhibited capsaicin-stimulated release of glutamate in both calcium-dependent and -independent manners…”
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PnPP-15, a Synthetic Peptide Derived from a Toxin from Phoneutria nigriventer Spider Venom, Alleviates Diabetic Neuropathic Pain and Acts Synergistically with Pregabalin in Mice by Mariano, Xavier Maia, de Assis Ferreira, Luana Caroline, Almeida-Leite, Camila Megale, de Castro Junior, Célio José, de Lima, Maria Elena

“…Diabetic neuropathic pain is one of the complications that affect a wide variety of the diabetic population and is often difficult to treat. Only a small…”
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PnPP-15, a Synthetic Peptide Derived from a Toxin from IPhoneutria nigriventer/I Spider Venom, Alleviates Diabetic Neuropathic Pain and Acts Synergistically with Pregabalin in Mice by Mariano, Xavier Maia, de Assis Ferreira, Luana Caroline, Almeida-Leite, Camila Megale, de Castro Junior, Célio José, de Lima, Maria Elena

“…Diabetic neuropathic pain is one of the complications that affect a wide variety of the diabetic population and is often difficult to treat. Only a small…”
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Effects of intravenous administration of recombinant Phα1β toxin in a mouse model of fibromyalgia by Garcia Mendes, Mariana Peluci, Carvalho dos Santos, Duana, Rezende, Márcio Júnior S., Assis Ferreira, Luana Caroline, Rigo, Flavia Karine, José de Castro Junior, Célio, Gomez, Marcus Vinicius

“…This study investigated the effects of intravenous (iv) administration of recombinant Phα1β toxin, pregabalin, and diclofenac by the intrathecal route using an…”
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The inhibitory effect of Phα1β toxin on diabetic neuropathic pain involves the CXCR4 chemokine receptor by da Silva Junior, Claudio Antonio, de Castro Junior, Célio José, Pereira, Elizete Maria Rita, Binda, Nancy Scardua, da Silva, Juliana Figueira, do Nascimento Cordeiro, Marta, Diniz, Danuza Montijo, Cecilia, Flavia Santa, Ferreira, Juliano, Gomez, Marcus Vinicius

“…Diabetic neuropathy is a common cause of painful diabetic neuropathy (PDN). C-X-C chemokine receptor type 4 (CXCR4) expression is increased in peripheral nerve…”
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The spider toxin Phα1β recombinant possesses strong analgesic activity by Rigo, Flavia Karine, Trevisan, Gabriela, De Prá, Samira Dal-Toé, Cordeiro, Marta Nascimento, Borges, Marcia Helena, Silva, Juliana Figueiredo, Santa Cecilia, Flavia Viana, de Souza, Alessandra Hubner, de Oliveira Adamante, Gabriela, Milioli, Alessandra Marcon, de Castro Junior, Célio José, Ferreira, Juliano, Gomez, Marcus Vinicius

“…The native Phα1β – a Voltage-Gated Calcium Channel (VGCC) blocker – and its Recombinant Version – were both tested in rodent pain models with an intraplantar…”
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Pharmacological Interaction Between Cannabidiol and Tramadol on Experimental Diabetic Neuropathic Pain: An Isobolographic Analysis by Evans, Allan Arnold, Jesus, Carlos Henrique Alves, Martins, Lucas Latchuk, Fukuyama, Alisson Hideki, Gasparin, Alexia Thamara, Crippa, José Alexandre, Zuardi, Antonio Waldo, Hallak, Jaime Eduardo Cecílio, Genaro, Karina, de Castro Junior, Célio José, Zanoveli, Janaina Menezes, Cunha, Joice Maria da

“…Diabetic neuropathies are the most prevalent chronic complications of diabetes, characterized by pain and substantial morbidity. Although many drugs have been…”
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Antinociceptive interaction in mice undergoing combined administration of Phα1β and morphine in a mice cancer pain model by Moura, Rodrigo Antônio Andrade, Aoki, Caio Tavares, Castro Junior, Célio José de, Ferreira, Luana Assis, Gomez, Marcus Vinícius

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Spider peptide Phα1β induces analgesic effect in a model of cancer pain by Rigo, Flavia Karine, Trevisan, Gabriela, Rosa, Fernanda, Dalmolin, Gerusa D., Otuki, Michel Fleith, Cueto, Ana Paula, Castro Junior, Célio José, Romano‐Silva, Marco Aurelio, Cordeiro, Marta do N., Richardson, Michael, Ferreira, Juliano, Gomez, Marcus V.

“…The marine snail peptide ziconotide (ω‐conotoxin MVIIA) is used as an analgesic in cancer patients refractory to opioids, but may induce severe adverse…”
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Interação antinociceptiva em camundongos submetidos a administração combinada da toxina Phα1β e morfina em um modelo de dor no câncer em camundongos by Moura, Rodrigo Antônio Andrade, Aoki, Caio Tavares, Castro Junior, Célio José de, Ferreira, Luana Assis, Gomez, Marcus Vinícius

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Interação antinociceptiva em camundongos submetidos a administração combinada da toxina Phα1β e morfina em um modelo de dor no câncer em camundongos by Moura, Rodrigo Antônio Andrade, Aoki, Caio Tavares, Castro Junior, Célio José de, Ferreira, Luana Assis, Gomez, Marcus Vinícius

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Phoneutria spider toxins block ischemia-induced glutamate release, neuronal death, and loss of neurotransmission in hippocampus by Pinheiro, Ana Cristina do Nascimento, da Silva, Adriano Jesus, Prado, Marco Antonio M., Cordeiro, Marta do Nascimento, Richardson, Michael, Batista, Monalise Costa, de Castro Junior, Célio José, Massensini, André Ricardo, Guatimosim, Cristina, Romano-Silva, Marco A., Kushmerick, Christopher, Gomez, Marcus Vinicius

“…The aim of this study was to investigate the effect of spider toxins on brain injury induced by oxygen deprivation and low glucose (ODLG) insult on slices of…”
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PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina by Binda, Nancy Scardua, Carayon, Charles Porto Petruceli, Agostini, Rafael Mourão, Pinheiro, Ana Cristina do Nascimento, Cordeiro, Marta Nascimento, Silva, Marco Aurélio Romano, Silva, Juliana Figueira, Pereira, Elizete Maria Rita, da Silva Junior, Claudio Antonio, de Castro Junior, Célio José, Guimarães, Andre Luiz Sena, Gomez, Marcus Vinicius

“…The in vivo neuroprotective effect of PhTx3-4, a spider toxin N-P/Q calcium channel blocker, was studied in a rat model of NMDA-induced injury of the retina…”
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Tx3-4 a toxin from the venom of spider Phoneutria nigriventer blocks calcium channels associated with exocytosis by de Castro Junior, Célio José, Pinheiro, Ana Cristina N., Guatimosim, Cristina, Cordeiro, Marta N., Souza, Alessandra H., Richardson, Michael, Romano-Silva, Marco A., Prado, Marco Antônio M., Gomez, Marcus V.

“…The purpose of the present work was to investigate the pharmacological action of a calcium channel-blocking toxin from the venom of the spider Phonetic…”
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The effect of spider toxin PhTx3-4, ω-conotoxins MVIIA and MVIIC on glutamate uptake and on capsaicin-induced glutamate release and Ca2+i in spinal cord synaptosomes by Gonçaves, Jomara M, Ferreira, Juliano, Prado, Marco Antonio M, Cordeiro, Marta N, Richardson, Michael, Pinheiro, Ana Cristina do Nascimento, Silva, Marco A Romano, Junior, Celio José de Castro, Souza, Alessandra H, Gomez, Marcus Vinicius

“…In spinal cord synaptosomes, the spider toxin PhTx3-4 inhibited capsaicin-stimulated release of glutamate in both calcium-dependent and -independent manners…”
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