Search Results - "Castro‐Chaves, Paulo"

Molecular Signature of Mineralocorticoid Receptor Signaling in Cardiomyocytes: From Cultured Cells to Mouse Heart by Latouche, Celine, Sainte-Marie, Yannis, Steenman, Marja, Castro Chaves, Paulo, Naray-Fejes-Toth, Aniko, Fejes-Toth, Geza, Farman, Nicolette, Jaisser, Frederic

“…Excess mineralocorticoid signaling is deleterious for cardiovascular functions, as demonstrated by the beneficial effects of mineralocorticoid receptor (MR)…”
Get full text

Original Intracerebral Hemorrhage Score for the Prediction of Short-Term Mortality in Cerebral Hemorrhage: Systematic Review and Meta-Analysis by Gregório, Tiago, Pipa, Sara, Cavaleiro, Pedro, Atanásio, Gabriel, Albuquerque, Inês, Castro Chaves, Paulo, Azevedo, Luís

“…OBJECTIVES:To systematically assess the discrimination and calibration of the Intracerebral Hemorrhage score for prediction of short-term mortality in…”
Get full text

Prognostic models for intracerebral hemorrhage: systematic review and meta-analysis by Gregório, Tiago, Pipa, Sara, Cavaleiro, Pedro, Atanásio, Gabriel, Albuquerque, Inês, Chaves, Paulo Castro, Azevedo, Luís

“…Prognostic tools for intracerebral hemorrhage (ICH) patients are potentially useful for ascertaining prognosis and recommended in guidelines to facilitate…”
Get full text

A 4-Variable Model to Predict Cardio-Kidney Events and Mortality in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort (CRIC) Study by Mendonça, Luís, Bigotte Vieira, Miguel, Neves, João Sérgio, Castro Chaves, Paulo, Ferreira, Joao Pedro

“…Current prognostic models for chronic kidney disease (CKD) are complex and were designed to predict a single outcome. We aimed to develop and validate a simple…”
Get more information

Physiological, pathological and potential therapeutic roles of adipokines by FAKAO-PIRES, Inês, CASTRO-CHAVES, Paulo, MIRANDA-SILVA, Daniela, LOURENCO, André P, LEITE-MOREIRA, Adelino F

“…Formerly regarded purely as passive energy storage, adipose tissue is now recognized as a vital endocrine organ. Adipocytes secrete diverse peptide hormones…”
Get full text

Acute Ischemic Stroke Outcome and Preceding Anticoagulation: Direct Oral Anticoagulants Versus Vitamin K Antagonists by Tavares, Sofia Felício, Ferreira, Inês, Chaves, Vanessa, Flores, Luis, Correia, Cristina, Almeida, Jorge, Fonseca, Luísa, Castro Chaves, Paulo

“…•Stroke severity was identical in pre-treated patients with direct and vitamin-K anticoagulants.•Infra-therapeutic anticoagulation was not associated with…”
Get full text

Angiotensin II-induced increase in myocardial distensibility and its modulation by the endocardial endothelium in the rabbit heart by Paulo Castro-Chaves, Ricardo Fontes-Carvalho, Mariana Pintalhao, Pedro Pimentel-Nunes, Adelino F. Leite-Moreira

“…As recently demonstrated, angiotensin II (Ang II) induces an increase in myocardial distensibility. Although endothelin-1 and the endocardial endothelium (EE)…”
Get full text

Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload by Pintalhao, Mariana, Castro‐Chaves, Paulo, Vasques‐Novoa, Francisco, Gonçalves, Francisco, Mendonça, Luís, Fontes‐Carvalho, Ricardo, Lourenço, Patrícia, Almeida, Pedro, Leite‐Moreira, Adelino, Bettencourt, Paulo

“…Aims Despite the promising results of serelaxin as a new potential acute heart failure (HF) therapy, its clinical use preceded the understanding of the…”
Get full text

Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients by Pereira, Catia S, Pérez-Cabezas, Begoña, Ribeiro, Helena, Maia, M Luz, Cardoso, M Teresa, Dias, Ana F, Azevedo, Olga, Ferreira, M Fatima, Garcia, Paula, Rodrigues, Esmeralda, Castro-Chaves, Paulo, Martins, Esmeralda, Aguiar, Patricio, Pineda, Mercè, Amraoui, Yasmina, Fecarotta, Simona, Leão-Teles, Elisa, Deng, Shenglou, Savage, Paul B, Macedo, M Fatima

“…The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. While defects in lipid antigen presentation and in invariant Natural Killer…”
Get full text

Negative inotropic effect of selective AT2 receptor stimulation and its modulation by the endocardial endothelium by CASTRO-CHAVES, Paulo, SOARES, Susana, FONTES-CARVALHO, Ricardo, LEITE-MOREIRA, Adelino F

“…Angiotensin II is an octapeptide whose effects are mediated by two types of receptors. AT(1) receptors are responsible for the vasoconstrictor, positive…”
Get full text

Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger‐mediated effect by Leite‐Moreira, Adelino F, Castro‐Chaves, Paulo, Pimentel‐Nunes, Pedro, Lima‐Carneiro, Alexandre, Guerra, Miguel S, Soares, João Bruno, Ferreira‐Martins, João

“…Acute effects of angiotensin II (AngII) on diastolic properties of the myocardium were investigated. Increasing concentrations of AngII (10−9 to 10−5 M) were…”
Get full text

Reply to “Approaching the ideal biomarker for right heart dysfunction” by Pintalhao, Mariana, Barros, António S., Castro-Chaves, Paulo

Get full text

Reply by Pintalhao, Mariana, Castro‐Chaves, Paulo, Bettencourt, Paulo

Get full text

Reply by Pintalhao, Mariana, Castro‐Chaves, Paulo, Bettencourt, Paulo

Get full text

Early anticoagulation in atrial fibrillation-related acute ischaemic stroke: efficacy and safety profile by Matos-Ribeiro, Joao, Castro-Chaves, Paulo, Oliveira-Ferreira, Marta, Fonseca, Luísa, Pintalhao, Mariana

“…Objectives To evaluate the effects of early anticoagulation on functional outcome, recurrent ischaemic events and haemorrhagic complications in Atrial…”
Get full text

Association between serum phosphorus and mortality in NHANES 2003–2006: the effect of gender and renal function by Mendonça, Luís, Gonçalves, Francisco, Sampaio, Susana, Castro-Chaves, Paulo, Pereira, Luciano

“…Background The impact of high serum phosphorus in the general population is still debated. Studies are heterogeneous, most lack an adjustment for parathyroid…”
Get full text

Prognostic association of circulating relaxin-2 in acute heart failure by Pintalhao, Mariana, Vasques-Nóvoa, Francisco, Barros, António S., Lourenço, Patrícia, Couto-Viana, Benedita, Leite-Moreira, Adelino, Bettencourt, Paulo, Castro-Chaves, Paulo

“…Despite the increasing interest in the study of the endogenous relaxin system in heart failure (HF), its role as a prognostic marker in acute HF remains…”
Get full text

NT-pro-BNP correlates with disease severity and predicts outcome in cerebral haemorrhage patients: Cohort study by Gregorio, Tiago, Albuquerque, Inês, Neves, Vasco, Reinas, Rui, Pipa, Sara, Azevedo, Luís, Chaves, Paulo Castro

“…Intracerebral haemorrhage (ICH) is a devastating condition, with more than half of patients dying or becoming dependent after such an event. Natriuretic…”
Get full text

Heart failure patients have enhanced cerebral autoregulation response in acute ischemic stroke by Castro, Pedro, Serrador, Jorge, Rocha, Isabel, Chaves, Paulo Castro, Sorond, Farzaneh, Azevedo, Elsa

“…The cerebrovascular effects of a failing heart-pump are largely unknown. Chronic heart failure (HF) might cause pre-conditioning effect on cerebral…”
Get full text

Assessment and Comparison of the Four Most Extensively Validated Prognostic Scales for Intracerebral Hemorrhage: Systematic Review with Meta-analysis by Gregório, Tiago, Pipa, Sara, Cavaleiro, Pedro, Atanásio, Gabriel, Albuquerque, Inês, Chaves, Paulo Castro, Azevedo, Luís

“…Background/Objective Intracerebral hemorrhage (ICH) is a devastating disorder, responsible for 10% of all strokes. Several prognostic scores have been…”
Get full text