Search Results - "Castro, Valeriana Di"

β-Arrestin links endothelin A receptor to β-catenin signaling to induce ovarian cancer cell invasion and metastasis by Rosanò, Laura, Cianfrocca, Roberta, Masi, Stefano, Spinella, Francesca, Di Castro, Valeriana, Biroccio, Annamaria, Salvati, Erica, Nicotra, Maria Rita, Natali, Pier Giorgio, Bagnato, Anna

“…The activation of endothelin-A receptor (ETAR) by endothelin-1 (ET-1) has a critical role in ovarian tumorigenesis and progression. To define the molecular…”
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Endothelin-1 Stimulates Lymphatic Endothelial Cells and Lymphatic Vessels to Grow and Invade by SPINELLA, Francesca, GARRAFA, Emirena, DI CASTRO, Valeriana, ROSANO, Laura, RITA NICOTRA, Maria, CARUSO, Arnaldo, GIORGIO NATALI, Pier, BAGNATO, Anna

“…The lymphatic vasculature is essential for tissue fluid homeostasis and cancer metastasis, although the molecular mechanisms involved remain poorly…”
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Endothelin-1 Induces an Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo by Salani, Debora, Taraboletti, Giulia, Rosanò, Laura, Di Castro, Valeriana, Borsotti, Patrizia, Giavazzi, Raffaella, Bagnato, Anna

“…The endothelial cell-derived endothelin-1 (ET-1) is a potent mitogen for endothelial cells, vascular smooth muscle cells, and tumor cells. In this study, we…”
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Role of Endothelin-1 in Neovascularization of Ovarian Carcinoma by Salani, Debora, Di Castro, Valeriana, Nicotra, Maria Rita, Rosanò, Laura, Tecce, Raffaele, Venuti, Aldo, Natali, Pier Giorgio, Bagnato, Anna

“…Endothelin-1 (ET-1) is overexpressed in ovarian carcinomas and acts, via ET A receptors (ET AR), as an autocrine growth factor. In this study we investigate…”
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β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer by Tocci, Piera, Cianfrocca, Roberta, Di Castro, Valeriana, Rosanò, Laura, Sacconi, Andrea, Donzelli, Sara, Bonfiglio, Silvia, Bucci, Gabriele, Vizza, Enrico, Ferrandina, Gabriella, Scambia, Giovanni, Tonon, Giovanni, Blandino, Giovanni, Bagnato, Anna

“…The limited clinical response observed in high-grade serous ovarian cancer (HG-SOC) with high frequency of TP53 mutations (mutp53) might be related to…”
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Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer by Sestito, Rosanna, Tocci, Piera, Roman, Celia, Di Castro, Valeriana, Bagnato, Anna

“…Epithelial-to-mesenchymal transition (EMT) encompasses a highly dynamic and complex key process which leads to metastatic progression. In high-grade serous…”
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Targeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP inhibition by Tocci, Piera, Roman, Celia, Sestito, Rosanna, Di Castro, Valeriana, Sacconi, Andrea, Molineris, Ivan, Paolini, Francesca, Carosi, Mariantonia, Tonon, Giovanni, Blandino, Giovanni, Bagnato, Anna

“…PARP inhibitors (PARPi) have changed the treatment paradigm of high-grade serous ovarian cancer (HG-SOC). However, the impact of this class of inhibitors in…”
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Endothelin-1 induces the transactivation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells by Spinella, Francesca, Caprara, Valentina, Di Castro, Valeriana, Rosanò, Laura, Cianfrocca, Roberta, Natali, Pier Giorgio, Bagnato, Anna

“…Endothelin receptor B (ET(B)R) is a G-protein-coupled receptor overexpressed in melanoma, blood, and lymphatic endothelial cells. Given that aberrant signal…”
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Macitentan blocks endothelin-1 receptor activation required for chemoresistant ovarian cancer cell plasticity and metastasis by Sestito, Rosanna, Cianfrocca, Roberta, Rosanò, Laura, Tocci, Piera, Di Castro, Valeriana, Caprara, Valentina, Bagnato, Anna

“…In epithelial ovarian cancer (EOC), activation of endothelin-1 (ET-1)/endothelin A receptor (ETAR) and ET-1/ETBR signaling is linked to many tumor promoting…”
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Endothelin-1 Inhibits Prolyl Hydroxylase Domain 2 to Activate Hypoxia-Inducible Factor-1α in Melanoma Cells by Spinella, Francesca, Rosanò, Laura, Del Duca, Martina, Di Castro, Valeriana, Nicotra, Maria Rita, Natali, Pier Giorgio, Bagnato, Anna

“…Background The endothelin B receptor (ETBR) promotes tumorigenesis and melanoma progression through activation by endothelin (ET)-1, thus representing a…”
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Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells by ROSANO, Laura, SPINELLA, Francesca, DI CASTRO, Valeriana, NICOTRA, Maria Rita, DEDHAR, Shoukat, GARCIA DE HERREROS, Antonio, GIORGIO NATALI, Pier, BAGNATO, Anna

“…Despite considerable efforts to improve early detection and advances in chemotherapy, metastatic relapses remain a major challenge in the management of ovarian…”
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Endothelin-1-induced Prostaglandin E2-EP2, EP4 Signaling Regulates Vascular Endothelial Growth Factor Production and Ovarian Carcinoma Cell Invasion by Spinella, Francesca, Rosanò, Laura, Di Castro, Valeriana, Natali, Pier Giorgio, Bagnato, Anna

“…Cyclooxygenase (COX)-1- and COX-2-derived prostaglandins are implicated in the development and progression of several malignancies. We have recently…”
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ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo by Rosanò, Laura, Di Castro, Valeriana, Spinella, Francesca, Nicotra, Maria Rita, Natali, Pier Giorgio, Bagnato, Anna

“…The autocrine endothelin (ET)-1/endothelin A receptor (ET A R) pathway is an important regulator of several processes involved in ovarian cancer progression,…”
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Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression by BAGNATO, Anna, ROSANO, Laura, SPINELLA, Francesca, DI CASTRO, Valeriana, TECCE, Raffaele, NATALI, Pier Giorgio

“…Phenotypic and genotypic analyses of cutaneous melanoma have identified the endothelin B receptor (ET(B)R) as tumor progression marker, thus representing a…”
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Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation by Del Bufalo, Donatella, Di Castro, Valeriana, Biroccio, Annamaria, Varmi, Marco, Salani, Debora, Rosanò, Laura, Trisciuoglio, Daniela, Spinella, Francesca, Bagnato, Anna

“…Endothelin-1 (ET-1) is a powerful mitogenic peptide produced by different tumors. In ovarian carcinoma cells, ET-1 acts as an autocrine growth factor,…”
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Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma by Rosanò, Laura, Spinella, Francesca, Di Castro, Valeriana, Dedhar, Shoukat, Nicotra, Maria Rita, Natali, Pier Giorgio, Bagnato, Anna

“…The endothelin-1 (ET-1) axis represents a novel target in several malignancies, including ovarian carcinoma. Upon being activated, the endothelin A receptor…”
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Endothelin axis induces metalloproteinase activation and invasiveness in human lymphatic endothelial cells by Spinella, Francesca, Caprara, Valentina, Garrafa, Emirena, Di Castro, Valeriana, Rosanò, Laura, Natali, Pier Giorgio, Bagnato, Anna

“…The molecular mechanisms involved in lymphangiogenesis were unknown until recently. We previously demonstrated that the endothelin-1 (ET-1) axis stimulates…”
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Endothelin-1 Decreases Gap Junctional Intercellular Communication by Inducing Phosphorylation of Connexin 43 in Human Ovarian Carcinoma Cells by Spinella, Francesca, Rosanò, Laura, Di Castro, Valeriana, Nicotra, Maria Rita, Natali, Pier Giorgio, Bagnato, Anna

“…Endothelin-1 (ET-1) is overexpressed in ovarian carcinoma and acts as an autocrine factor selectively through the ETA receptor (ETAR) to promote tumor cell…”
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Inhibition of Cyclooxygenase-1 and -2 Expression by Targeting the Endothelin A Receptor in Human Ovarian Carcinoma Cells by SPINELLA, Francesca, ROSANO, Laura, DI CASTRO, Valeriana, NICOTRA, Maria Rita, NATALI, Pier Giorgio, BAGNATO, Anna

“…Purpose and Experimental Design: New therapies against cancer are based on targeting cyclooxygenase (COX)-2. Activation of the endothelin A receptor (ET A R)…”
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Retraction Note: Endothelin-1 induces the transactivation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells by Spinella, Francesca, Caprara, Valentina, Di Castro, Valeriana, Rosanò, Laura, Cianfrocca, Roberta, Natali, Pier Giorgio, Bagnato, Anna

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