Search Results - "Castro, Sandra B. R."
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Immunomodulatory Effects of Anadenanthera colubrina Bark Extract in Experimental Autoimmune Encephalomyelitis
Published in Current issues in molecular biology (01-08-2024)“…This study aimed to evaluate the efficacy of the ethanolic extract of in modulating the immune response in the Experimental Autoimmune Encephalomyelitis (EAE)…”
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Immunomodulatory effects and improved prognosis of experimental autoimmune encephalomyelitis after O-tetradecanoyl-genistein treatment
Published in International immunopharmacology (01-02-2012)“…Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis (MS), a human inflammatory demyelinating…”
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Synthesis and evaluation of cytotoxicity and inhibitory effect on nitric oxide production by J774A.1 macrophages of new anthraquinone derivatives
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01-09-2013)“…Mitoxantrone is an anthracene-based anticancer agent whose efficacy in treating autoimmune diseases is believed to be due to cytotoxicity and inhibition of…”
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Anthraquinone derivative O,O′-bis-(3′-iodopropyl)-1,4-dihidroxyanthraquinone modulates immune response and improves experimental autoimmune encephalomyelitis
Published in International immunopharmacology (01-10-2012)“…The present study investigated the effects of the anthraquinone derivative (O,O′-bis-(3′-iodopropyl)-1,4-dihidroxyanthraquinone — DIPDHAQ), mitoxantrone…”
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Protease inhibitors characterisation by SDS-PAGE and MALDI-TOF from Alocasia macrorrhizos and their modulation of macrophage immune-inflammatory properties
Published in Natural product research (01-10-2024)“…This study describes the extraction and identification by electrophoretic and spectrometric techniques of protease inhibitor from the medicinal plant Alocasia…”
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In vitro and in vivo evaluation of anti-inflammatory activity and free radical scavenging potential of leaves extract from Anadenanthera colubrina
Published in Natural product research (18-11-2021)“…The present study highlights the antioxidant and anti-inflammatory activities from Anadenanthera colubrina leaves ethanolic extract (EEAc) and its…”
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In vitro antitumor effects of aqueous extract and protease inhibitors from Sterculia striata st. Hil. et naud and metabolite profiling
Published in Natural product research (06-02-2024)“…The present study aims to assess the cytotoxic effect of the aqueous and protease inhibitors extracts of on breast cancer cell lines. The results showed…”
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Dereplication of Siparuna brasiliensis extract with in vivo anti-inflammatory activity
Published in Natural product research (01-06-2023)“…is a medicinal plant widely used by indigenous communities of the Amazon rainforest to treat inflammatory diseases and related pathologies. Considering its…”
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Metabolic profiling by LC-DAD-MS, FTIR, NMR and CE-UV of polyphenols with potential against skin pigmentation disorder
Published in Natural product research (01-04-2023)“…In traditional Brazilian medicine, tubers extracts from are widely used in the treatment of skin pigmentation disorder. However, studies that evaluate its…”
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Miconia albicans and Curcuma longa herbal medicines positively modulate joint pain, function and inflammation in patients with osteoarthritis: a clinical study
Published in Inflammopharmacology (01-04-2021)“…This study aims to evaluate the analgesic and modulating effect of Curcuma longa and Miconia albicans herbal medicines in knee’s osteoarthritis (OA) treatment…”
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Stem cells from human-exfoliated deciduous teeth reduce tissue-infiltrating inflammatory cells improving clinical signs in experimental autoimmune encephalomyelitis
Published in Biologicals (01-09-2017)“…Stem cells from human exfoliated deciduous teeth (SHED) have great therapeutic potential and here, by the first time, we evaluated their immunomodulatory…”
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Synthesis of genistein coupled with sugar derivatives and their inhibitory effect on nitric oxide production in macrophages
Published in European journal of medicinal chemistry (06-10-2014)“…The isoflavone genistein 1 and some derivatives modulate IL-12, TNF-α and NO production by macrophages and lung cancer cell lines, and improve the clinical…”
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Cecropia hololeuca: A new source of compounds with potential anti-inflammatory action
Published in Natural product research (12-08-2021)“…Our objective is to investigate the phytochemical components, antioxidant capacity and in vitro and in vivo anti-inflammatory action from Cecropia hololeuca…”
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Lipophilic amino alcohols reduces carrageenan-induced paw edema and anti-OVA DTH in BALB/c mice
Published in International immunopharmacology (01-11-2013)“…The inflammation process is a coordinated response of the organism related to immune response with release of pro-inflammatory substances, as nitric oxide,…”
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Synthesis of 1,4-Anthracene-9,10-dione Derivatives and Their Regulation of Nitric Oxide, IL-1β and TNF-α in Activated RAW264.7 Cells
Published in Chemical biology & drug design (01-10-2013)“…Mitoxantrone is an anthracenedione antineoplastic and immunosuppressive agent approved for multiple sclerosis treatment. Novel mono‐ and disubstituted…”
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Synthesis of Lipophilic Genistein Derivatives and Their Regulation of IL-12 and TNF-α in Activated J774A.1 Cells
Published in Chemical biology & drug design (01-03-2012)“…Genistein modulates inflammatory responses in part by reducing the production of the pro‐inflammatory cytokines IL‐12, TNF‐α, and nitric oxide, by activated…”
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Preparation of Amino Alcohols Condensed with Carbohydrates: Evaluation of Cytotoxicity and Inhibitory Effect on NO Production
Published in Chemical biology & drug design (01-11-2010)“…This work reports the preparation of several amino alcohols condensed with d-arabinose, d-glucose, and d-galactose derivatives. These compounds were evaluated…”
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Ursolic Acid Derivatives Down Regulate Inflammatory Mediators
Published in Journal of the Brazilian Chemical Society (2023)“…Ursolic acid (UA) is being investigated due to its anti-inflammatory potential, and structural modifications can enhance its biological activities. The aim of…”
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Multifunctionality of βCD/Ofloxacin and HPβCD/Ofloxacin Complexes: Improvement of the Antimicrobial Activity and Apoptosis Induction on Lung Adenocarcinoma A549 Cells
Published in Journal of the Brazilian Chemical Society (2020)“…The ofloxacin (OFLOX) is a second-generation synthetic antibiotic that can be classified as a multifunctional drug, but is a poorly soluble drug, which…”
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Synthesis of 1,4‐Anthracene‐9,10‐dione Derivatives and Their Regulation of Nitric Oxide, IL ‐1 β and TNF ‐ α in Activated RAW 264.7 Cells
Published in Chemical biology & drug design (01-10-2013)“…Mitoxantrone is an anthracenedione antineoplastic and immunosuppressive agent approved for multiple sclerosis treatment. Novel mono‐ and disubstituted…”
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