Search Results - "Castro, Mauro A. A"

Regulators of genetic risk of breast cancer identified by integrative network analysis by Castro, Mauro A A, de Santiago, Ines, Campbell, Thomas M, Vaughn, Courtney, Hickey, Theresa E, Ross, Edith, Tilley, Wayne D, Markowetz, Florian, Ponder, Bruce A J, Meyer, Kerstin B

“…Kerstin Meyer and colleagues analyze a breast cancer gene regulatory network generated using publicly available expression and ChIP-seq data sets. They…”
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Expression-based subtypes define pathologic response to neoadjuvant immune-checkpoint inhibitors in muscle-invasive bladder cancer by Robertson, A. Gordon, Meghani, Khyati, Cooley, Lauren Folgosa, McLaughlin, Kimberly A., Fall, Leigh Ann, Yu, Yanni, Castro, Mauro A. A., Groeneveld, Clarice S., de Reyniès, Aurélien, Nazarov, Vadim I., Tsvetkov, Vasily O., Choy, Bonnie, Raggi, Daniele, Marandino, Laura, Montorsi, Francesco, Powles, Thomas, Necchi, Andrea, Meeks, Joshua J.

“…Checkpoint immunotherapy (CPI) has increased survival for some patients with advanced-stage bladder cancer (BCa). However, most patients do not respond. Here,…”
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ERα Binding by Transcription Factors NFIB and YBX1 Enables FGFR2 Signaling to Modulate Estrogen Responsiveness in Breast Cancer by Campbell, Thomas M, Castro, Mauro A A, de Oliveira, Kelin Gonçalves, Ponder, Bruce A J, Meyer, Kerstin B

“…Two opposing clusters of transcription factors (TF) have been associated with the differential risks of estrogen receptor positive or negative breast cancers,…”
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Cholinergic Differentiation of Human Neuroblastoma SH-SY5Y Cell Line and Its Potential Use as an In vitro Model for Alzheimer’s Disease Studies by de Medeiros, Liana M., De Bastiani, Marco A., Rico, Eduardo P., Schonhofen, Patrícia, Pfaffenseller, Bianca, Wollenhaupt-Aguiar, Bianca, Grun, Lucas, Barbé-Tuana, Florência, Zimmer, Eduardo R., Castro, Mauro A. A., Parsons, Richard B., Klamt, Fábio

“…Cholinergic transmission is critical to high-order brain functions such as memory, learning, and attention. Alzheimer’s disease (AD) is characterized by…”
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A transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma by Warrick, Joshua I., Knowles, Margaret A., Hurst, Carolyn D., Shuman, Lauren, Raman, Jay D., Walter, Vonn, Putt, Jeffrey, Dyrskjøt, Lars, Groeneveld, Clarice, Castro, Mauro A. A., Robertson, A. Gordon, DeGraff, David J.

“…Human cancers display a restricted set of expression profiles, despite diverse mutational drivers. This has led to the hypothesis that select sets of…”
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Long non-coding RNAs identify a subset of luminal muscle-invasive bladder cancer patients with favorable prognosis by de Jong, Joep J, Liu, Yang, Robertson, A Gordon, Seiler, Roland, Groeneveld, Clarice S, van der Heijden, Michiel S, Wright, Jonathan L, Douglas, James, Dall'Era, Marc, Crabb, Simon J, van Rhijn, Bas W G, van Kessel, Kim E M, Davicioni, Elai, Castro, Mauro A A, Lotan, Yair, Zwarthoff, Ellen C, Black, Peter C, Boormans, Joost L, Gibb, Ewan A

“…Muscle-invasive bladder cancer (MIBC) is a heterogeneous disease, and gene expression profiling has identified several molecular subtypes with distinct…”
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An analysis of the global expression of microRNAs in an experimental model of physiological left ventricular hypertrophy by Martinelli, Nidiane C, Cohen, Carolina R, Santos, Kátia G, Castro, Mauro A, Biolo, Andréia, Frick, Luzia, Silvello, Daiane, Lopes, Amanda, Schneider, Stéfanie, Andrades, Michael E, Clausell, Nadine, Matte, Ursula, Rohde, Luis E

“…MicroRNAs (miRs) are a class of small non-coding RNAs that regulate gene expression. Studies of transgenic mouse models have indicated that deregulation of a…”
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Cannabidiol Exposure During Neuronal Differentiation Sensitizes Cells Against Redox-Active Neurotoxins by Schönhofen, Patrícia, de Medeiros, Liana M., Bristot, Ivi Juliana, Lopes, Fernanda M., De Bastiani, Marco A., Kapczinski, Flávio, Crippa, José Alexandre S., Castro, Mauro Antônio A., Parsons, Richard B., Klamt, Fábio

“…Cannabidiol (CBD), one of the most abundant Cannabis sativa -derived compounds, has been implicated with neuroprotective effect in several human pathologies…”
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Unraveling Immune-Related lncRNAs in Breast Cancer Molecular Subtypes by Mathias, Carolina, Muzzi, João Carlos Degraf, Antunes, Bruna Borba, Gradia, Daniela F., Castro, Mauro A. A., Carvalho de Oliveira, Jaqueline

“…Breast cancer (BRCA) is the most leading cause of cancer worldwide. It is a heterogeneous disease with at least five molecular subtypes including luminal A,…”
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Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy by Campbell, Thomas M, Castro, Mauro A A, Ponder, Bruce A J, Meyer, Kerstin B

“…We have recently identified transcription factors (TFs) that are key drivers of breast cancer risk. To better understand the pathways or sub-networks in which…”
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Comprehensive Characterization of the Regulatory Landscape of Adrenocortical Carcinoma: Novel Transcription Factors and Targets Associated with Prognosis by Muzzi, João C. D, Magno, Jéssica M, Souza, Jean S, Alvarenga, Larissa M, de Moura, Juliana F, Figueiredo, Bonald C, Castro, Mauro A. A

“…We reconstructed a transcriptional regulatory network for adrenocortical carcinoma (ACC) using transcriptomic and clinical data from The Cancer Genome Atlas…”
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RedeR: R/Bioconductor package for representing modular structures, nested networks and multiple levels of hierarchical associations by Castro, Mauro AA, Wang, Xin, Fletcher, Michael NC, Meyer, Kerstin B, Markowetz, Florian

“…Visualization and analysis of molecular networks are both central to systems biology. However, there still exists a large technological gap between them,…”
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Adrenocortical Carcinoma Steroid Profiles: In Silico Pan-Cancer Analysis of TCGA Data Uncovers Immunotherapy Targets for Potential Improved Outcomes by Muzzi, João C D, Magno, Jessica M, Cardoso, Milena A, de Moura, Juliana, Castro, Mauro A A, Figueiredo, Bonald C

“…Despite progress in understanding the biology of adrenocortical carcinoma (ACC), treatment options have not dramatically changed in the last three decades, nor…”
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Novel lncRNAs Co-Expression Networks Identifies LINC00504 with Oncogenic Role in Luminal A Breast Cancer Cells by Mathias, Carolina, Groeneveld, Clarice S, Trefflich, Sheyla, Zambalde, Erika P, Lima, Rubens S, Urban, Cícero A, Prado, Karin B, Ribeiro, Enilze M S F, Castro, Mauro A A, Gradia, Daniela F, de Oliveira, Jaqueline C

“…Long non-coding RNAs (lncRNAs) are functional transcripts with more than 200 nucleotides. These molecules exhibit great regulatory capacity and may act at…”
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Posterior association networks and functional modules inferred from rich phenotypes of gene perturbations by Wang, Xin, Castro, Mauro A, Mulder, Klaas W, Markowetz, Florian

“…Combinatorial gene perturbations provide rich information for a systematic exploration of genetic interactions. Despite successful applications to bacteria and…”
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ViaComplex: software for landscape analysis of gene expression networks in genomic context by Castro, Mauro A. A., Filho, José L. Rybarczyk, Dalmolin, Rodrigo J. S., Sinigaglia, Marialva, Moreira, José C. F., Mombach, José C. M., de Almeida, Rita M. C.

“…ViaComplex is an open-source application that builds landscape maps of gene expression networks. The motivation for this software comes from two previous…”
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Correction: preferential duplication of intermodular hub genes: an evolutionary signature in eukaryotes genome networks by Ferreira, Ricardo M, Rybarczyk-Filho, José Luiz, Dalmolin, Rodrigo J S, Castro, Mauro A A, Moreira, José C F, Brunnet, Leonardo G, de Almeida, Rita M C

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Integrative Analysis Identifies Genetic Variants Associated With Autoimmune Diseases Affecting Putative MicroRNA Binding Sites by de Almeida, Rodrigo C, Chagas, Vinícius S, Castro, Mauro A A, Petzl-Erler, Maria L

“…Genome-wide and fine mapping studies have shown that more than 90% of genetic variants associated with autoimmune diseases (AID) are located in non-coding…”
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Validation of cofilin-1 as a biomarker in non-small cell lung cancer: application of quantitative method in a retrospective cohort by Müller, Carolina B., de Barros, Rafael L. S., Castro, Mauro A. A., Lopes, Fernanda M., Meurer, Rosalva T., Roehe, Adriana, Mazzini, Guilherme, Ulbrich-kulczynski, Jane Maria, Dal-Pizzol, Felipe, Fernandes, Marilda C., Moreira, José C. F., Xavier, Léder L., Klamt, Fábio

“…Purpose Cofilin is a cytoskeletal protein whose overexpression has been associated with aggressiveness in several types of malignancies. Here, we established…”
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High cofilin-1 levels correlate with cisplatin resistance in lung adenocarcinomas by Becker, Matheus, De Bastiani, Marco Antônio, Müller, Carolina Beatriz, Markoski, Melissa M., Castro, Mauro Antônio A., Klamt, Fábio

“…High cofilin-1 levels have been shown to be an accurate prognostic biomarker in non-small cell lung cancer (NSCLC) and a predictive factor in drug resistance…”
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