Search Results - "Castro, Maite A."
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Exosomes as Novel Regulators of Adult Neurogenic Niches
Published in Frontiers in cellular neuroscience (19-01-2016)“…Adult neurogenesis has been convincingly demonstrated in two regions of the mammalian brain: the sub-granular zone (SGZ) of the dentate gyrus (DG) in the…”
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The sodium/ascorbic acid co-transporter SVCT2 distributes in a striated membrane-enriched domain at the M-band level in slow-twitch skeletal muscle fibers
Published in Biological research (06-11-2024)“…Abstract Background Vitamin C plays key roles in cellular homeostasis, functioning as a potent antioxidant and a positive regulator of cell differentiation. In…”
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3
metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid
Published in Journal of neurochemistry (01-07-2009)“…In this review, we discuss a novel function of ascorbic acid in brain energetics. It has been proposed that during glutamatergic synaptic activity neurons…”
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Huntington's disease leads to decrease of GABA-A tonic subunits in the D2 neostriatal pathway and their relocalization into the synaptic cleft
Published in Neurobiology of disease (01-02-2018)“…GABA is a widely distributed inhibitory neurotransmitter. GABA-A receptors are hetero-pentameric channels assembled in multiple combinations from 19 available…”
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The Tiny Drosophila Melanogaster for the Biggest Answers in Huntington's Disease
Published in International journal of molecular sciences (14-08-2018)“…The average life expectancy for humans has increased over the last years. However, the quality of the later stages of life is low and is considered a public…”
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Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination
Published in eLife (20-08-2024)“…Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative…”
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Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines
Published in Frontiers in cellular neuroscience (23-02-2021)“…Herpes simplex virus type 1 (HSV-1) is a widespread neurotropic virus. Primary infection of HSV-1 in facial epithelium leads to retrograde axonal transport to…”
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Agonist-dependent modulation of cell surface expression of the cold receptor TRPM8
Published in The Journal of neuroscience (14-01-2015)“…The spatial and temporal distribution of receptors constitutes an important mechanism for controlling the magnitude of cellular responses. Several members of…”
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Near-membrane dynamics and capture of TRPM8 channels within transient confinement domains
Published in PloS one (11-10-2010)“…The cold and menthol receptor, TRPM8, is a non-selective cation channel expressed in a subset of peripheral neurons that is responsible for neuronal detection…”
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The adjustment of γ-aminobutyric acidA tonic subunits in Huntington's disease: from transcription to translation to synaptic levels into the neostriatum
Published in Neural regeneration research (01-04-2018)“…γ-Aminobutyric acid (GABA), plays a key role in all stages of life, also is considered the main inhibitory neurotransmitter. GABA activates two kind of…”
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The Presence and Function of Dopamine Type 2 Receptors in Boar Sperm: A Possible Role for Dopamine in Viability, Capacitation, and Modulation of Sperm Motility
Published in Biology of reproduction (01-04-2009)“…Several studies have shown that dopamine and other catecholamines are present in oviduct luminal fluid. We recently reported that dopamine type 2 receptors…”
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Vitamin C and oxidative stress in the seminiferous epithelium
Published in Biological research (2011)“…In this article, we focus on the fundamental role of vitamin C transporters for the normal delivery of vitamin C to germ cells in the adluminal compartment of…”
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Neuron‐glia (mis)interactions in brain energy metabolism during aging
Published in Journal of neuroscience research (01-03-2022)“…Life expectancy in humans is increasing, resulting in a growing aging population, that is accompanied by an increased disposition to develop cognitive…”
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Dietary Fructose Promotes Prostate Cancer Growth
Published in Cancer research (Chicago, Ill.) (01-06-2021)“…Clinical localization of primary tumors and sites of metastasis by PET is based on the enhanced cellular uptake of 2-deoxy-2-[ F]-fluoro-D-glucose (FDG). In…”
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A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington’s disease in mice
Published in Nature communications (13-12-2013)“…Huntington’s disease has been associated with a failure in energy metabolism and oxidative damage. Ascorbic acid is a powerful antioxidant highly concentrated…”
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Wheat germ agglutinin-conjugated fluorescent pH sensors for visualizing proton fluxes
Published in The Journal of general physiology (01-06-2020)“…Small-molecule fluorescent wheat germ agglutinin (WGA) conjugates are routinely used to demarcate mammalian plasma membranes, because they bind to the cell's…”
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A simple solution for antibody signal enhancement in immunofluorescence and triple immunogold assays
Published in Histochemistry and cell biology (01-10-2016)“…Immunolocalization techniques are standard in biomedical research. Tissue fixation with aldehydes and cell membrane permeabilization with detergents can…”
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Beyond the redox imbalance: Oxidative stress contributes to an impaired GLUT3 modulation in Huntington's disease
Published in Free radical biology & medicine (01-12-2015)“…Failure in energy metabolism and oxidative damage are associated with Huntington's disease (HD). Ascorbic acid released during synaptic activity inhibits use…”
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Impaired intracellular trafficking of sodium‐dependent vitamin C transporter 2 contributes to the redox imbalance in Huntington’s disease
Published in Journal of neuroscience research (01-01-2021)“…Huntington's disease (HD) is a neurodegenerative disorder caused by a glutamine expansion at the first exon of the huntingtin gene. Huntingtin protein (Htt) is…”
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Glutathione Depletion Induces Spermatogonial Cell Autophagy
Published in Journal of cellular biochemistry (01-10-2015)“…ABSTRACT The development and survival of male germ cells depend on the antioxidant capacity of the seminiferous tubule. Glutathione (GSH) plays an important…”
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