Search Results - "Castro, Mª Ángeles"
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Impact of the laser scanning strategy on the quality of 17-4PH stainless steel parts manufactured by selective laser melting
Published in Journal of materials research and technology (01-09-2022)“…A significant correlation between scanning strategies and the quality of parts manufactured additively with Selective Laser Melting (SLM) technology is shown…”
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Improving Properties of Podophyllic Aldehyde-Derived Cyclolignans: Design, Synthesis and Evaluation of Novel Lignohydroquinones, Dual-Selective Hybrids against Colorectal Cancer Cells
Published in Pharmaceutics (01-03-2023)“…New lignohydroquinone conjugates (L-HQs) were designed and synthesized using the hybridization strategy, and evaluated as cytotoxics against several cancer…”
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Synthesis and Biological Evaluation of New Podophyllic Aldehyde Derivatives with Cytotoxic and Apoptosis-Inducing Activities
Published in Journal of medicinal chemistry (11-02-2010)“…Several series of nonlactonic podophyllic aldehyde analogues were prepared and evaluated against several human tumor cell lines. They had different…”
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Lignopurines: A new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation
Published in European journal of medicinal chemistry (01-12-2012)“…A new family of hybrids between cyclolignans related to podophyllic aldehyde, a non-lactonic cyclolignan, and purines were prepared and evaluated against…”
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Anti-Herpetic, Anti-Dengue and Antineoplastic Activities of Simple and Heterocycle-Fused Derivatives of Terpenyl-1,4-Naphthoquinone and 1,4-Anthraquinone
Published in Molecules (Basel, Switzerland) (02-04-2019)“…Quinones are secondary metabolites of higher plants associated with many biological activities, including antiviral effects and cytotoxicity. In this study,…”
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Cytotoxic Cyclolignans Obtained by the Enlargement of the Cyclolignan Skeleton of Podophyllic Aldehyde, a Selective Podophyllotoxin-Derived Cyclolignan
Published in Molecules (Basel, Switzerland) (01-04-2024)“…Podophyllotoxin, a cyclolignan natural product, has been the object of extensive chemomodulation to obtain better chemotherapeutic agents. Among the obtained…”
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Bioactive Prenyl- and Terpenyl-Quinones/Hydroquinones of Marine Origin
Published in Marine drugs (21-08-2018)“…The sea is a rich source of biological active compounds, among which terpenyl-quinones/hydroquinones constitute a family of secondary metabolites with diverse…”
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Podophyllic Aldehyde, a Podophyllotoxin Derivate, Elicits Different Cell Cycle Profiles Depending on the Tumor Cell Line: A Systematic Proteomic Analysis
Published in International journal of molecular sciences (01-05-2024)“…When new antitumor therapy drugs are discovered, it is essential to address new target molecules from the point of view of chemical structure and to carry out…”
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Chemical characterization and bioactive properties of two aromatic plants: Calendula officinalis L. (flowers) and Mentha cervina L. (leaves)
Published in Food & function (18-05-2016)“…The chemical composition and bioactive properties of two plants (Calendula officinalis L. and Mentha cervina L.) were studied. Their nutritional value revealed…”
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New Antineoplastic Naphthohydroquinones Attached to Labdane and Rearranged Diterpene Skeletons
Published in Molecules (Basel, Switzerland) (18-01-2021)“…Terpenylquinones are mixed biogenesis primary or secondary metabolites widespread in Nature with many biological activities, including the antineoplastic…”
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New Hybrids Derived from Podophyllic Aldehyde and Diterpenylhydroquinones with Selectivity toward Osteosarcoma Cells
Published in ACS medicinal chemistry letters (12-04-2018)“…A new family of molecular hybrids, between cyclolignans related to podophyllic aldehyde and several diterpenylnaphthohydroquinones (DNHQ), was prepared and its…”
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Cytotoxic Terphenyl Neolignans from Fungus Terana coerulea: New Natural Corticins D and E. and Revised Structure for Corticin A
Published in Natural product communications (01-05-2017)“…The cobalt crust fungus Terana coerulea (Phanerochaetaceae family) was selected for a bio-guided study after an ethnobotanical survey at the Irati's Forest…”
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Creaci´on e implementaci´on de Entornos Virtuales para mejorar los procesos ense˜nanza-aprendizaje en las Pr´acticas de Laboratorio
Published in Modelling in science education and learning (31-01-2023)“…Los ensayos realizados durante las prácticas de laboratorio de las asignaturas de Ciencia, Tecnología e Ingeniería de Materiales en los Grados de Ingeniería…”
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Synthesis and antifungal activity of terpenyl-1,4-naphthoquinone and 1,4-anthracenedione derivatives
Published in European journal of medicinal chemistry (01-09-2013)“…The antifungal evaluation of twenty seven simple and heterocycle-fused prenyl-1,4-naphthoquinones and 1,4-anthracenediones was performed in vitro against human…”
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A safe, convenient and efficient method for the preparation of heterocyclic N-oxides using urea·hydrogen peroxide
Published in Tetrahedron letters (24-11-2008)“…A novel, convenient, and high-yielding method has been developed for the preparation of heterocyclic N-oxides. The reaction uses the urea·hydrogen peroxide…”
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Synthesis and cytotoxicity of new aminoterpenylquinones
Published in Bioorganic & medicinal chemistry (01-02-2005)“…Several 6(7)-alkyl-2-(alkyl/arylamino)-1,4-naphthoquinones (NQ) have been prepared and evaluated as cytotoxics. Those with p-oxyarylamino substituents were the…”
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Synthesis, characterisation and cytotoxicity of chloro derivatives of prenylnaphthohydroquinone
Published in Bioorganic & medicinal chemistry (01-06-2005)“…A family of chloroprenylnaphthohydroquinoned derivatives have been synthesised from the acetylated Diels–Alder product 2, of α-myrcene and…”
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New Selective Cytotoxic Diterpenylquinones and Diterpenylhydroquinones
Published in Journal of medicinal chemistry (12-04-2001)“…A new series of diterpenylquinone/hydroquinones has been prepared by Diels−Alder cycloaddition between three labdanic diterpenoids (myrceocommunic acid, methyl…”
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Synthesis and bioactivity of new antineoplastic terpenylquinones
Published in Bioorganic & medicinal chemistry letters (06-08-1996)“…Several monoterpenylquinones have been prepared and evaluated for their cytotoxic activity against four cell lines cultures. The size of the quinone fragment…”
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