Search Results - "Castro, Helena C."

Nasal therapy—The missing link in optimising strategies to improve prevention and treatment of COVID-19 by Ratcliffe, Norman A, Castro, Helena C, Paixão, Izabel C, Evangelho, Victor G. O, Azambuja, Patricia, Mello, Cicero B

“…Only natural infections induce both IgG1to protect the lungs as well as IgA1 to protect the upper respiratory tract, including the nasal passages [16]…”
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Antibacterial naphthoquinone derivatives targeting resistant strain Gram-negative bacteria in biofilms by Novais, Juliana S., Moreira, Caroline S., Silva, Ana Carolina J.A., Loureiro, Raquel S., Sá Figueiredo, Agnes Marie, Ferreira, Vitor F., Castro, Helena C., da Rocha, David R.

“…The aims of this study were the planning, synthesis and in vitro evaluation of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones against Gram-negative and…”
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Facing Racism and Sexism in Science by Fighting Against Social Implicit Bias: A Latina and Black Woman’s Perspective by Calaza, Karin C., Erthal, Fátima C. S., Pereira, Mirtes G., Macario, Kita C. D., Daflon, Verônica T., David, Isabel P. A., Castro, Helena C., Vargas, Maria D., Martins, Laura B., Stariolo, Jasmin B., Volchan, Eliane, de Oliveira, Leticia

“…The editors of several major journals have recently asserted the importance of combating racism and sexism in science. This is especially relevant now, as the…”
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Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography by Page, Michael J., Lourenço, André L., David, Tovo, LeBeau, Aaron M., Cattaruzza, Fiore, Castro, Helena C., VanBrocklin, Henry F., Coughlin, Shaun R., Craik, Charles S.

“…Functional imaging of proteolytic activity is an emerging strategy to quantify disease and response to therapy at the molecular level. We present a new…”
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Sodium montmorillonite/amine-containing drugs complexes: new insights on intercalated drugs arrangement into layered carrier material by Bello, Murilo L, Junior, Aridio M, Vieira, Bárbara A, Dias, Luiza R S, de Sousa, Valéria P, Castro, Helena C, Rodrigues, Carlos R, Cabral, Lucio M

“…Layered drug delivery carriers are current targets of nanotechnology studies since they are able to accommodate pharmacologically active substances and are…”
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Synthesis, tuberculosis inhibitory activity, and SAR study of N-substituted-phenyl-1,2,3-triazole derivatives by Costa, Marilia S., Boechat, Núbia, Rangel, Érica A., da Silva, Fernando de C., de Souza, Alessandra M.T., Rodrigues, Carlos R., Castro, Helena C., Junior, Ivan N., Lourenço, Maria Cristina S., Wardell, Solange M.S.V., Ferreira, Vitor F.

“…Tuberculosis (TB) is caused by Mycobacterium tuberculosis and remains as a leading cause of mortality worldwide. The in vitro anti-tuberculosis screening of…”
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Efficient Synthesis and Antibacterial Profile of Bis(2-hydroxynaphthalene- 1,4-dione) by Novais, Juliana S, Rosandiski, Aline C, de Carvalho, Carolina M, de Saules Silva, Letícia S, Dos S Velasco de Souza, Lais C, Santana, Marcos V, Martins, Nathalia R C, Castro, Helena C, Ferreira, Vitor F, Gonzaga, Daniel T G, de Resende, Gabriel O, de C da Silva, Fernando

“…Antibacterial resistance is a serious public health problem infecting millions in the global population. Currently, there are few antimicrobials on the market…”
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In Vitro Evaluation of Essential Oils Derived from Piper nigrum (Piperaceae) and Citrus limonum (Rutaceae) against the Tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) by Chagas, Evelize Folly das, Castro, Helena C., Souza, Kauê F. C. S., da Silva Vaz, Itabajara, Nunes, Maria Júlia, Nogueira, Jeane, Meloni, Jéssica, Mattos, Camila, Vinturelle, Rafaelle, Lione, Viviane

“…The present research aimed to study the chemical composition and acaricidal activity of Citrus limonum and Piper nigrum essential oils against the cattle tick…”
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Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides by JORDAO, Alessandro K, FERREIRA, Vitor F, LIMA, Emerson S, DE SOUZA, Maria C. B. V, CARLOS, Eduardo C. L, CASTRO, Helena C, GERALDO, Reinaldo B, RODRIGUES, Carlos R, ALMEIDA, Maria C. B, CUNHA, Anna C

“…This paper describes the synthesis, antiplatelet and theoretical evaluations of 10 N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides…”
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Synthesis and anti-platelet activity of novel arylsulfonate–acylhydrazone derivatives, designed as antithrombotic candidates by Lima, Lídia M., Frattani, Flávia S., dos Santos, Jean L., Castro, Helena C., Fraga, Carlos Alberto M., Zingali, Russolina B., Barreiro, Eliezer J.

“…In this work, we describe a new class of promising anti-platelet drug candidates with significant antithrombotic activity in vivo. This new series of compounds…”
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Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors by Gonzaga, Daniel T G, Oliveira, Felipe H, von Ranke, N L, Pinho, G Q, Salles, Juliana P, Bello, Murilo L, Rodrigues, Carlos R, Castro, Helena C, de Souza, Hellen V C M, Reis, Caroline R C, Leme, Rennan P P, Mafra, João C M, Pinheiro, Luiz C S, Hoelz, Lucas V B, Boechat, Nubia, Faria, Robson X

“…Twenty new 2-(1 -pyrazol-1-yl)-1,3,4-thiadiazole analogs were synthetized to develop P2X7 receptor (P2X7R) inhibitors. P2X7R inhibition was evaluated in mouse…”
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Synthesis, antichagasic in vitro evaluation, cytotoxicity assays, molecular modeling and SAR/QSAR studies of a 2-phenyl-3-(1-phenyl-1 H-pyrazol-4-yl)-acrylic acid benzylidene-carbohydrazide series by Vera-DiVaio, Maria A.F., Freitas, Antônio C.C., Castro, Helena C., de Albuquerque, Sérgio, Cabral, Lucio M., Rodrigues, Carlos R., Albuquerque, Magaly G., Martins, Rita C.A., Henriques, Maria G.M.O., Dias, Luiza R.S.

“…The 6k (X = H, Y = NO 2, pIC 50 = 4.55 M) and 6l (X = F, Y = CN, pIC 50 = 4.27 M) are the most potent trypanocidal agents. However, 6l showed the most…”
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4-(1H-Pyrazol-1-yl) benzenesulfonamide derivatives: identifying new active antileishmanial structures for use against a neglected disease by Marra, Roberta K F, Bernardino, Alice M R, Proux, Tathiane A, Charret, Karen S, Lira, Marie-Luce F, Castro, Helena C, Souza, Alessandra M T, Oliveira, Cesar D, Borges, Júlio C, Rodrigues, Carlos R, Canto-Cavalheiro, Marilene M, Leon, Leonor L, Amaral, Veronica F

“…Leishmaniasis is a neglected disease responsible for about 56,000 deaths every year. Despite its importance, there are no effective, safe and proper treatments…”
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Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series by Dias, Luiza R S, Santos, Marcelo B, Albuquerque, Sérgio de, Castro, Helena C, de Souza, Alessandra M T, Freitas, Antônio C C, DiVaio, Maria A V, Cabral, Lucio M, Rodrigues, Carlos R

“…The development of new drugs against Trypanosoma cruzi is still required since the only two drugs currently used cause severe side effects. In this work we…”
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Computational Studies of Benzoxazinone Derivatives as Antiviral Agents against Herpes Virus Type 1 Protease by Mello, Juliana F R, Botelho, Nathália C, Souza, Alessandra M T, Oliveira, Riethe, Brito, Monique A, Abrahim-Vieira, Bárbara de A, Sodero, Ana Carolina R, Castro, Helena C, Cabral, Lucio M, Miceli, Leonardo A, Rodrigues, Carlos R

“…Herpes simplex virus infections have been described in the medical literature for centuries, yet the the drugs available nowadays for therapy are largely…”
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Molecular docking studies of marine diterpenes as inhibitors of wild-type and mutants HIV-1 reverse transcriptase by Miceli, Leonardo A, Teixeira, Valéria L, Castro, Helena C, Rodrigues, Carlos R, Mello, Juliana F R, Albuquerque, Magaly G, Cabral, Lucio M, de Brito, Monique A, de Souza, Alessandra M T

“…AIDS is a pandemic responsible for more than 35 million deaths. The emergence of resistant mutations due to drug use is the biggest cause of treatment failure…”
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Therapeutic nanosystems for oral administration of insulin by do Carmo, Flavia A, Sathler, Plinio C, Zancan, Patricia, Rodrigues, Carlos R, Castro, Helena C, de Sousa, Valeria P, Sola-Penna, Mauro, Cabral, Lucio M

“…The treatment of Diabetes Mellitus (DM), a chronic disease, is primarily based upon administration of insulin forms to patients. Conventional subcutaneous…”
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Sulphonamide and sulphonyl-hydrazone cyclic imide derivatives: Antinociceptive activity, molecular modeling and In Silico ADMET screening by de Oliveira, Kely N., Souza, Márcia M., Sathler, Plínio Cunha, Magalhães, Uiaran O., Rodrigues, Carlos R., Castro, Helena C., Palm, Patrícia R., Sarda, Maicon, Perotto, Pablo E., Cezar, Sabrina, de Brito, Monique A., Ferreira, Ariane S. S. R., Cabral, Lúcio Mendes, Machado, Clodoaldo, Nunes, Ricardo J.

“…In this paper, we describe the antinociceptive activity, molecular modeling and in silico ADMET screening of a series of sulphonyl-hydrazone and sulphonamide…”
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SAR of a series of anti-HSV-1 acridone derivatives, and a rational acridone-based design of a new anti-HSV-1 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine series by BERNARDINO, Alice M. R, CASTRO, Helena C, ALBUQUERQUE, Magaly G, CABRAL, Lucio M, RODRIGUES, Carlos R, FRUGULHETTI, Izabel C. P. P, LOUREIRO, Natalia I. V, AZEVEDO, Alexandre R, PINHEIRO, Luiz C. S, SOUZA, Thiago M. L, GIONGO, Viveca, PASSAMANI, Fabiana, MAGALHAES, Uiaran O

“…Herpes Simplex Virus (HSV) infections are among the most common human diseases. In this work, we assess the structural features and electronic properties of a…”
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Isolation and molecular characterization of a major hemolymph serpin from the triatomine, Panstrongylus megistus by Moreira, Carlos JC, Waniek, Peter J, Valente, Richard H, Carvalho, Paulo C, Perales, Jonas, Feder, Denise, Geraldo, Reinaldo B, Castro, Helena C, Azambuja, Patricia, Ratcliffe, Norman A, Mello, Cícero B

“…BACKGROUND: Chagas disease kills 2.5 thousand people per year of 15 million persons infected in Latin America. The disease is caused by the protozoan,…”
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