Association of serum levels of secreted frizzled-related protein 5 and Wnt member 5a with glomerular filtration rate in patients with type 2 diabetes mellitus and chronic renal disease: a cross-sectional study

BACKGROUNDDiabetic nephropathy is a common complication of chronic kidney disease (CKD). -Inflammation in the kidneys is crucial for promoting development and progression of this complication. Wnt member 5a (Wnt5a) and secreted frizzled-related protein 5 (Sfrp5) are proinflammatory proteins associat...

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Published in:	São Paulo medical journal Vol. 138; no. 2; pp. 133 - 139
Main Authors:	Báez, Indira Rojo, Castro, Daniel Omar Rivera, Gutiérrez, Sarahí Salas, López, Edgar Dehesa, Lemarroy, Adriana Aguilar, Suarez, Luis Felipe Jave, Ureta, Hipólito Castillo, Montoya, Edith Hilario Torres, Andalón, Vicente Olimón
Format:	Journal Article
Language:	English
Published:	Associação Paulista de Medicina - APM 01-03-2020 Associação Paulista de Medicina
Subjects:	anti-inflammatory cytokine diabetes mellitus diabetes mellitus, type 2 diabetic nephropathy elisa quantification MEDICINE, GENERAL & INTERNAL Original renal insufficiency, chronic sfrp5 sfrp5 protein, human [supplementary concept] wnt5a wnt5a protein, human [supplementary concept] Wnt5a protein, human [supplementary concept] Renal insufficiency, chronic Diabetes mellitus, type 2 ELISA quantification Wnt5a Sfrp5 Diabetes mellitus Anti-inflammatory cytokine Diabetic nephropathy Sfrp5 protein, human [supplementary concept]
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Summary:	BACKGROUNDDiabetic nephropathy is a common complication of chronic kidney disease (CKD). -Inflammation in the kidneys is crucial for promoting development and progression of this complication. Wnt member 5a (Wnt5a) and secreted frizzled-related protein 5 (Sfrp5) are proinflammatory proteins associated with insulin resistance and chronic low-grade adipose tissue inflammation. OBJECTIVETo determine the correlation between serum Sfrp5 and Wnt5a concentrations and glomerular filtration rate in patients with type 2 diabetes mellitus and CKD. DESIGN AND SETTINGCross-sectional, comparative and observational study in the Department of Endocrinology, Civil Hospital, Culiacán, Sinaloa, Mexico. METHODSEighty individuals with chronic kidney disease were recruited. Their serum Sfrp5 and Wnt5a concentrations were quantified using the enzyme-linked immunosorbent assay (ELISA) test. The statistical analysis consisted of the Mann-Whitney U test for independent samples and Spearman correlation, with statistical significance of P < 0.05. RESULTSSerum Sfrp5 concentration continually increased through the stages of CKD progression, whereas serum Wnt5a concentration presented its highest levels in stage 3 CKD. Negative correlations between estimated glomerular filtration rate (eGFR) and serum concentrations of Sfrp5 (r = -0434, P = 0.001) and Wnt5a (r = -0481, P = 0.001) were found. CONCLUSIONSThere were negative correlations between serum Sfrp5 and Wnt5a concentrations and eGFR at each stage of CKD, with higher levels in female patients. This phenomenon suggests that Sfrp5 and Wnt5a might be involved in development and evolution towards end-stage renal disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conflict of interest: None Authors’ contributions: All the authors approved the version to be published and gave their agreement to be responsible for all aspects of the work, so as to ensure that questions relating to the accuracy or integrity of all the work are appropriately investigated and resolved
ISSN:	1516-3180 1806-9460 1806-9460
DOI:	10.1590/1516-3180.2019.0304.r2.09122019