Comparison of dialysis dose through real-time Kt/V by ultraviolet absorbance of spent dialysate, single-pool Daugirdas II, and Kt/BSA according to sex and age

Kt/V OnLine (Kt/VOL) avoids inaccuracies associated with the estimation of urea volume distribution (V). The study aimed to compare Kt/VOL, Kt/V Daugirdas II, and Kt/BSA according to sex and age. Urea volume distribution and body surface area were obtained by Watson and Haycock formulas in 47 patien...

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Bibliographic Details
Published in:	Brazilian Journal of Nephrology Vol. 43; no. 1; pp. 52 - 60
Main Authors:	Marrocos, Mauro Sergio Martins, Castro, Christine Nastri, Barbosa, Wilder Araujo, Sizo, Andressa Monteiro, Rodrigues, Fernanda Teles, Lima, Rosemary Alves de, Rodrigues, Sandra Maria
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Nefrologia 01-01-2021
Subjects:	Body Surface Area Dialysis Solutions Female Humans Male Matched-Pair Analysis Online Systems Original Renal Dialysis Urea
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Summary:	Kt/V OnLine (Kt/VOL) avoids inaccuracies associated with the estimation of urea volume distribution (V). The study aimed to compare Kt/VOL, Kt/V Daugirdas II, and Kt/BSA according to sex and age. Urea volume distribution and body surface area were obtained by Watson and Haycock formulas in 47 patients. V/BSA was considered as a conversion factor from Kt/V to Kt/BSA. Dry weight was determined before the study. Kt/VOL was obtained on DIALOG machines. Pearson correlation between Kt/VOL vs Kt/VII and Kt/VOL vs Kt/BSA was significant for males (r = 0.446, P = 0.012 and r = -0.476 P = 0.007) and individuals < 65 years (0.457, P = 0.019 and -0.549 P = 0.004), but not for females and individuals ≥ 65 years. V/BSA between individuals < 65 and individuals ≥ 65 years were 18.28 ± 0.15 and 18.18 ± 0.16 P = 0.000). No agreement between Kt/VII vs Kt/BSA. Men and individuals > 65 years received a larger dialysis dose than, respectively, females and individuals < 65 years, in the comparison between Kt/VOL versus Kt/VII. V/BSA ratios among men and women were respectively 18.29 ± 0.13 and 18.12 ± 0.15 P = 0.000. Kt/VOL allows recognition of real-time dose regardless of sex and age.
Bibliography:	The authors declare that they have no competing interests. Author’s Contribution Conflict of Interest Mauro Sergio Martins Marrocos contributed with study design, clinical data collection, coordination, statistical analysis and writing of the manuscript. Cristine Nastri Castro contributed with clinical data collection and writing of the manuscript. Wilder Araujo Barbosa contributed with clinical data collection and writing of the manuscript. Andressa Monteiro Sizo contributed with clinical data collection and writing of the manuscript. Fernanda Teles Rodrigues contributed with clinical data collection and writing of the manuscript. Rosemary Alves de Lima contributed with clinical data collection, coordination and writing of the manuscript. Sandra Maria Rodrigues Laranja contributed with study design, coordination and statistical analysis. All authors read and approved the final manuscript.
ISSN:	0101-2800 2175-8239
DOI:	10.1590/2175-8239-JBN-2020-0081