Search Results - "Castro, Bernardo Galvão"
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HTLV-1 is predominantly sexually transmitted in Salvador, the city with the highest HTLV-1 prevalence in Brazil
Published in PloS one (03-02-2017)“…Salvador is the city with the highest number of HTLV-1 infected individuals in Brazil, yet the main route of HTLV-1 transmission is unknown. To investigate the…”
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Blocking HTLV-1/2 silent transmission in Brazil: Current public health policies and proposal for additional strategies
Published in PLoS neglected tropical diseases (01-09-2021)“…Human T-cell lymphotropic viruses 1 and 2 (HTLV-1/2) are relatively common in Brazil but remain silent and neglected infections. HTLV-1 is associated with a…”
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Molecular characterization of HTLV‐1 genomic region hbz from patients with different clinical conditions
Published in Journal of medical virology (01-11-2021)“…The human T‐cell lymphotropic virus type‐1 (HTLV‐1) is associated with severe pathologies, such as HTLV‐1‐associated myelopathy/tropical spastic paraparesis…”
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Imbalanced IL10/TGF-β production by regulatory T-lymphocytes in patients with HTLV-1-associated myelopathy/ tropical spastic paraparesis
Published in BMC infectious diseases (28-06-2024)“…Human T-cell lymphotropic virus type 1 (HTLV-1), also denominated Human T-cell leukemia virus-1, induces immune activation and secretion of proinflammatory…”
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Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV-1-infected individuals
Published in Journal of neurovirology (01-12-2021)“…The association between high proviral load (PVL) in peripheral blood mononuclear cells (PBMC), cognitive disturbance and white matter brain lesions in…”
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Epidemiological and molecular evidence of intrafamilial transmission through sexual and vertical routes in Bahia, the state with the highest prevalence of HTLV-1 in Brazil
Published in PLoS neglected tropical diseases (01-09-2023)“…Familial clustering of HTLV-1 and related diseases has been reported in Brazil. However, intrafamilial transmission of HTLV-1 based on molecular analysis has…”
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Prevalence and characteristics of HTLV-associated uveitis in patients from Bahia, an endemic area for HTLV − 1 in Brazil
Published in Virology journal (21-08-2023)“…HTLV-1-associated uveitis (HAU) is an inflammatory reaction of the choroid, retina, optic nerve and vitreous that can lead to vision impairment. The worldwide…”
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Distribution of Human T-Lymphotropic Virus (HTLV) and Hepatitis C Co-infection in Bahia, Brazil
Published in PloS one (21-07-2020)“…Both Human T-lymphotropic virus type 1 (HTLV-1) and hepatitis C virus (HCV) are endemic in Brazil. In Salvador, the capital of the state of Bahia, 2% and 1.5%…”
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HIV/Aids and COVID-19 in Brazil: in four decades, two antithetical approaches to face serious pandemics
Published in Memórias do Instituto Oswaldo Cruz (01-01-2021)“…In the space of four decades, Brazil has faced two serious pandemics: human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and…”
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Laboratory diagnosis of human T-lymphotropic virus in Brazil: assays, flowcharts, challenges, and perspectives
Published in Revista da Sociedade Brasileira de Medicina Tropical (01-01-2021)“…We present a data analysis and review of recent studies regarding the laboratory diagnosis of human T-lymphotropic virus 1 and 2 (HTLV-1/2) infections in…”
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Efficacy of Corticosteroid Therapy for HTLV-1-Associated Myelopathy: A Randomized Controlled Trial (HAMLET-P)
Published in Viruses (12-01-2022)“…Corticosteroids are most commonly used to treat HTLV-1-associated myelopathy (HAM); however, their clinical efficacy has not been tested in randomized clinical…”
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Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil
Published in Frontiers in microbiology (14-05-2019)“…Salvador, Bahia (northeastern Brazil), has been identified as the epicenter of Human T-cell leukemia virus Human T-cell leukemia virus (HTLV) type 1 infection…”
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Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV)
Published in Frontiers in microbiology (26-02-2021)“…Co-infection between the human T-cell lymphotropic virus (HTLV) and the hepatitis C virus (HCV) can modify the natural history of HCV infection. The aim of…”
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Challenges in establishing telehealth care during the COVID-19 pandemic in a neglected HTLV-1-infected population in northeastern Brazil
Published in PLoS neglected tropical diseases (01-12-2020)“…In an attempt to contain the SARS-CoV-2 epidemic, the Brazilian Health Ministry recognized the epidemic as a public health emergency of national importance on…”
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Impaired flexibility in patients with tropical spastic paraparesis/HTLV-associated myelopathy: evaluation via pendulum fleximeter
Published in Arquivos de neuro-psiquiatria (01-03-2023)“…Abstract Background Flexibility is crucial to the harmonious execution of joint movements. While skeletal muscle dysfunction in patients with HTLV-1 can…”
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Anthelmintic treatment follow up in a rural community in Camamu, Bahia, Brazil
Published in Anais da Academia Brasileira de Ciências (01-01-2023)“…Enteroparasites are an important public health problem and the treatment seeks to cure and reduce transmission. The aim of this study was to evaluate the…”
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Co-dependence of HTLV-1 p12 and p8 functions in virus persistence
Published in PLoS pathogens (01-11-2014)“…HTLV-1 orf-I is linked to immune evasion, viral replication and persistence. Examining the orf-I sequence of 160 HTLV-1-infected individuals; we found…”
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Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP
Published in Journal of medical virology (01-07-2011)“…A high human T‐cell lymphotropic virus type 1 (HTLV‐1) proviral load is described in HTLV‐1‐associated diseases, especially HAM/TSP. However, the cut‐off value…”
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Comprehensive Antiretroviral Restriction Factor Profiling Reveals the Evolutionary Imprint of the ex Vivo and in Vivo IFN-β Response in HTLV-1-Associated Neuroinflammation
Published in Frontiers in microbiology (22-05-2018)“…HTLV-1-Associated Myelopathy (HAM/TSP) is a progressive neuroinflammatory disorder for which no disease-modifying treatment exists. Modest clinical benefit…”
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HTLV-1 Proviral Load in Vaginal Fluid Correlates with Levels in Peripheral Blood Mononuclear Cells
Published in Pathogens (Basel) (05-05-2023)“…The prevalence of human T-lymphotropic virus type-1 (HTLV-1) infection is higher in women, and sexual intercourse has been described as an important route of…”
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