Performance Evaluation of Geometrically Different Pediatric Arterial Cannulae in a Pediatric Cardiopulmonary Bypass Model

OBJECTIVETo define a reference chart comparing pressure drop vs. flow generated by a set of arterial cannulae currently utilized in cardiopulmonary bypass conditions in pediatric surgery.METHODSCannulae from two manufacturers were selected considering their design and outer and inner diameters. Cann...

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Published in:	Revista brasileira de cirurgia cardiovascular Vol. 39; no. 1; p. e20230110
Main Authors:	Carvalho, Gabriela B. de O., Caneo, Luiz Fernando, Matte, Gregory, Cruz, Caio Henrique de A., Silva, Everton Neri da, Carletto, Luciana P., Castro, Ana Vitória C. X. de, Silva, Betina G. Madueño, Policarpo, Valéria C., Cestari, Idágene A., Jatene, Fabio B, Jatene, Marcelo Biscegli
Format:	Journal Article
Language:	English
Published:	Sociedade Brasileira de Cirurgia Cardiovascular 01-01-2024
Subjects:	CARDIAC & CARDIOVASCULAR SYSTEMS SURGERY Congenital Heart Disease Cardiopulmonary Bypass Cannula Ringer’s Lactate Hematocrit Heart-Lung Machine
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Summary:	OBJECTIVETo define a reference chart comparing pressure drop vs. flow generated by a set of arterial cannulae currently utilized in cardiopulmonary bypass conditions in pediatric surgery.METHODSCannulae from two manufacturers were selected considering their design and outer and inner diameters. Cannula performance was evaluated in terms of pressure drop vs. flow during simulated cardiopulmonary bypass conditions. The experimental circuits consisted of a Jostra HL-20 roller pump, a Quadrox-i pediatric oxygenator (Maquet Cardiopulmonary AG, Rastatt, Germany), and a custom pediatric tubing set. The circuit was primed with lactated Ringer's solution only (first condition) and with human packed red blood cells added (second condition) to achieve a hematocrit of 30%. Cannula sizes 8 to 16 Fr were inserted into the cardiopulmonary bypass circuit with a "Y" connector. The flow was adjusted in 100 ml/min increments within typical flow ranges for each cannula. Pre-cannula and post-cannula pressures were measured to calculate the pressure drop.RESULTSUtilizing a pressure drop limit of 100 mmHg, our results suggest a recommended flow limit of 500, 900, 1400, 2600, and 3100 mL/min for Braile arterial cannulae sizes 8, 10, 12, 14, and 16 Fr, respectively. For Medtronic DLP arterial cannulae sizes 8, 10, 12, 14, and 16 Fr, the recommended flow limit is 600, 1100, 1700, 2700, and 3300 mL/min, respectively.CONCLUSIONThis study reinforces discrepancies in pressure drop between cannulae of the same diameter supplied by different manufacturers and the importance of independent translational research to evaluate components' performance.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1678-9741 1678-9741
DOI:	10.21470/1678-9741-2023-0110