Search Results - "Castro, Alexandre Luz de"
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The progression of pulmonary arterial hypertension induced by monocrotaline is characterized by lung nitrosative and oxidative stress, and impaired pulmonary artery reactivity
Published in European journal of pharmacology (15-01-2021)“…The time-course of pulmonary arterial hypertension in the monocrotaline (MCT) model was investigated. Male rats were divided into two groups: MCT (received a…”
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Carvedilol and thyroid hormones co-administration mitigates oxidative stress and improves cardiac function after acute myocardial infarction
Published in European journal of pharmacology (05-07-2019)“…After acute myocardial infarction (AMI), reactive oxygen species and oxidative stress have important roles in the progression to heart failure. As a…”
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Melatonin effects on oxidative stress and on TLR4/NF-kβ inflammatory pathway in the right ventricle of rats with pulmonary arterial hypertension
Published in Molecular and cellular endocrinology (01-10-2024)“…Pulmonary arterial hypertension (PAH) is characterised by an increase in mean pulmonary arterial pressure and a compromised the right ventricle (RV), together…”
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Sulforaphane Effects on Cardiac Function and Calcium-Handling–Related Proteins in 2 Experimental Models of Heart Disease: Ischemia-Reperfusion and Infarction
Published in Journal of cardiovascular pharmacology (01-03-2022)“…Sulforaphane (SFN) is a natural exogenous antioxidant from cruciferous vegetables already shown to improve cardiac function in cardiovascular diseases. The aim…”
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Influence of carvedilol and thyroid hormones on inflammatory proteins and cardioprotective factor HIF-1α in the infarcted heart
Published in Canadian journal of physiology and pharmacology (01-02-2023)“…Inflammatory pathways of Toll-like receptor 4 (TLR4) and NLRP3 inflammasome contribute to acute myocardial infarction (AMI) pathophysiology. The…”
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Impact of thyroid hormones and grape juice on biochemical markers and metabolic control proteins in experimental pulmonary arterial hypertension
Published in Brazilian Journal of Pharmaceutical Sciences (01-01-2024)“…Background-Pulmonary arterial hypertension (PAH) increases afterload in the right ventricle (RV), inducing adverse ventricular remodelling. Objective- This…”
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Effects of sleep restriction during pregnancy on the mother and fetuses in rats
Published in Physiology & behavior (01-03-2016)“…Abstract The present study aimed to analyze the effects of sleep restriction (SR) during pregnancy in rats. The following three groups were studied: home cage…”
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Thyroid hormone treatment improved the response to maximum exercise test and preserved the ventricular geometry in myocardial infarcted rats
Published in Experimental physiology (01-09-2020)“…New Findings What is the central question of this study? Does thyroid hormone treatment given after myocardial infarction preserve left ventricular function…”
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Cardioprotective effects of thyroid hormones in a rat model of myocardial infarction are associated with oxidative stress reduction
Published in Molecular and cellular endocrinology (25-06-2014)“…•This study evaluated thyroid hormones effects in oxidative stress after infarction.•T3 and T4 administration reduced ROS levels induced by myocardial…”
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Effect of free and nanoencapsulated copaiba oil on monocrotaline-induced pulmonary arterial hypertension
Published in Journal of cardiovascular pharmacology (01-02-2017)“…ABSTRACTCopaiba oil comes from an Amazonian tree and has been used as an alternative medicine in Brazil. However, it has not been investigated yet in the…”
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Decreased PGC1-α levels and increased apoptotic protein signaling are associated with the maladaptive cardiac hypertrophy in hyperthyroidism
Published in Journal of biosciences (01-12-2018)“…Hyperthyroidism can lead to the activation of proteins which are associated with inflammation, apoptosis, hypertrophy, and heart failure. This study aimed to…”
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Neonatal hyperglycemia induces cell death in the rat brain
Published in Metabolic brain disease (01-02-2018)“…Several studies have examined neonatal diabetes, a rare disease characterized by hyperglycemia and low insulin levels that is usually diagnosed in the first…”
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The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction
Published in Anais da Academia Brasileira de Ciências (01-01-2021)“…Acute myocardial infarction (AMI) is one of the major causes of heart failure and mortality. Glucocorticoids administration post-infarction has long been…”
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Effect of free and nanoemulsified β-caryophyllene on monocrotaline-induced pulmonary arterial hypertension
Published in Biochimica et biophysica acta. Molecular cell research (01-04-2024)“…Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary vascular resistance (PVR), right ventricular (RV) failure and premature death…”
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Sulforaphane improves redox homeostasis and right ventricular contractility in a model of pulmonary hypertension
Published in Journal of cardiovascular pharmacology (01-06-2024)“…Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary vascular resistance, imposing overload on the right ventricle (RV) and imbalance…”
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Melatonin improves nitric oxide bioavailability in isoproterenol induced myocardial injury
Published in Molecular and cellular endocrinology (15-09-2024)“…Isoproterenol administration is associated with cardiac inflammation and decreased NO availability. Melatonin has been reported to have cardioprotective…”
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Effects of Pterostilbene on Heart and Lung Oxidative Stress Parameters in 2 Experimental Models of Cardiovascular Disease: Myocardial Infarction and Pulmonary Arterial Hypertension
Published in Journal of cardiovascular pharmacology (01-07-2024)“…Myocardial infarction (MI) and pulmonary arterial hypertension (PAH) are 2 prevalent cardiovascular diseases. In both conditions, oxidative stress is…”
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Effects of Carvedilol and Thyroid Hormones Co-administration on Apoptotic and Survival Proteins in the Heart After Acute Myocardial Infarction
Published in Journal of cardiovascular pharmacology (01-12-2020)“…Cellular death and survival signaling plays a key role in the progress of adverse cardiac remodeling after acute myocardial infarction (AMI). Therapeutic…”
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Cardioprotective doses of thyroid hormones improve NO bioavailability in erythrocytes and increase HIF-1α expression in the heart of infarcted rats
Published in Archives of physiology and biochemistry (02-11-2022)“…Infarction leads to a decrease in NO bioavailability in the erythrocytes. Thyroid hormones (TH) present positive effects after infarction. However, there are…”
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