Search Results - "Castoldi, Elisabetta"

Advances in understanding the bleeding diathesis in factor V deficiency by Duckers, Connie, Simioni, Paolo, Rosing, Jan, Castoldi, Elisabetta

“…Summary Coagulation factor V (FV), present in plasma and platelets, is an indispensable clotting factor, as demonstrated by the uniform lethality of FV…”
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Severe thrombophilia in a factor V‐deficient patient homozygous for the Ala2086Asp mutation (FV Besançon) by Castoldi, Elisabetta, Hézard, Nathalie, Mourey, Guillaume, Wichapong, Kanin, Poggi, Marjorie, Ibrahim‐Kosta, Manal, Thomassen, M. Christella L. G. D., Fournel, Alexandra, Hayward, Catherine P. M., Alessi, Marie‐Christine, Hackeng, Tilman M., Rosing, Jan, Morange, Pierre‐Emmanuel

“…Background Coagulation factor V (FV), present in plasma and platelets, has both pro‐ and anticoagulant functions. Objective We investigated an FV‐deficient…”
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Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation by Brouns, Sanne L. N., van Geffen, Johanna P., Campello, Elena, Swieringa, Frauke, Spiezia, Luca, van Oerle, René, Provenzale, Isabella, Verdoold, Remco, Farndale, Richard W., Clemetson, Kenneth J., Spronk, Henri M. H., van der Meijden, Paola E. J., Cavill, Rachel, Kuijpers, Marijke J. E., Castoldi, Elisabetta, Simioni, Paolo, Heemskerk, Johan W. M.

“…In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a…”
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Antisense-Mediated Down-Regulation of Factor V-Short Splicing in a Liver Cell Line Model by Todaro, Alice M., Hackeng, Tilman M., Castoldi, Elisabetta

“…Coagulation factor V (FV) is a liver-derived protein encoded by the F5 gene. Alternative splicing of F5 exon 13 produces a low-abundance splicing isoform,…”
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Negatively charged phospholipids stimulate factor XI activation by thrombin by Omarova, Farida, Rosing, Jan, Bertina, Rogier M., Castoldi, Elisabetta

“…Coagulation factor XI (FXI) is the zymogen of the serine-protease FXIa, which contributes to thrombin formation by activating factor IX. FXI can be activated…”
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Case Report: Laboratory detection of a thrombotic tendency in a family with hypodysfibrinogenemia and a novel FGG mutation by Monard, Amaury, Castoldi, Elisabetta, De Simone, Ilaria, Wichapong, Kanin, van Duijl, Tirsa, van den Biggelaar, Maartje, Spada, Stefano, van Doorn, William, Hellenbrand, Dave, van der Meijden, Paola, Swieringa, Frauke, Stork, Alexander, Ten Cate, Hugo, Beckers, Erik, Heubel-Moenen, Floor, Henskens, Yvonne

“…Hypodysfibrinogenemia is a rare congenital fibrinogen disorder (CFD) which may induce thrombotic and bleeding events. Therefore, patient management needs…”
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Making sense of FV short by Castoldi, Elisabetta

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PB2642: EVALUATION OF INNOVATIVE LABORATORY TESTS TO PREDICT A THROMBOTIC PHENOTYPE IN A FAMILY WITH DYSFIBRINOGENEMIA AND A NOVEL FGG MUTATION by Monard, Amaury, Heubel‐Moenen, Fs.C.J.I., Castoldi, Elisabetta, De Simone, Ilaria, Meijden, P.E.J., Wichapong, Kanin, Doorn, W.P.T.M., Spada, Stefano, Hellenbrand, D.L.S., Stork, A.D.M., Cate, Hugo Ten, Beckers, E.A.M., Henskens, Y.M.C.

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F5‐Atlanta: Factor V‐short strikes again by Castoldi, Elisabetta

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Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiency by CASTOLDI, Elisabetta, MAURISSEN, Lisbeth F. A, TORMENE, Daniela, SPIEZIA, Luca, GAVASSO, Sabrina, RADU, Claudia, HACKENG, Tilman M, ROSING, Jan, SIMIONI, Paolo

“…Protein S, which circulates in plasma in both free and bound forms, is an anticoagulant protein that stimulates activated protein C and tissue factor pathway…”
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An underestimated combination of opposites resulting in enhanced thrombotic tendency by Simioni, Paolo, Castoldi, Elisabetta, Lunghi, Barbara, Tormene, Daniela, Rosing, Jan, Bernardi, Francesco

“…Heterozygous carriers of factor V (FV) Leiden who also carry FV deficiency often develop venous thromboembolism, but the thrombosis risk associated with this…”
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Illustrated State‐of‐the‐Art Capsules of the ISTH 2020 Congress by Ariens, Robert, Becattini, Cecilia, Bender, Markus, Bergmeier, Wolfgang, Castoldi, Elisabetta, Devreese, Katrien, Ellis, Martin, Gailani, David, Ignjatovic, Vera, James, Paula D., Kerrigan, Steven, Lambert, Michele, Lee, Lai Heng, Levi, Marcel, Maugeri, Norma, Meijers, Joost, Melero‐Martin, Juan, Michelson, Alan D., Mingozzi, Federico, Neeves, Keith, Ni, Heyu, Olsson, Anna‐Karin, Prohászka, Zoltán, Ranson, Marie, Riva, Nicoletta, Senis, Yotis, van Ommen, Cornelia H., Vaughan, Douglas E., Weisel, John

“…The 2020 Congress of the International Society of Thrombosis and Haemostasis (ISTH) was held virtually July 12‐15, 2019, due to the coronavirus disease 2019…”
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Factor V Leiden: a disorder of factor V anticoagulant function by Castoldi, Elisabetta, Rosing, Jan

“…PURPOSE OF REVIEWActivated protein C (APC) resistance, which is often associated with the factor V R506Q (FV Leiden) mutation, is a common risk factor for…”
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Thrombin generation tests by Castoldi, Elisabetta, Rosing, Jan

“…Abstract The recent development of semi-automated methods has revived interest in the thrombin generation test, a global assay that measures the overall…”
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FV and APC resistance: the plot thickens by Castoldi, Elisabetta

“…In this issue of Blood, Nogami et al report on a novel factor V (FV) gene mutation (FV Trp1920→Arg, FVNara) associated with activated protein C (APC)…”
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Post-transcriptional control of hemostatic genes: mechanisms and emerging therapeutic concepts in thrombo-inflammatory disorders by Danckwardt, Sven, Tregouet, David-Alexandre, Castoldi, Elisabetta

“…The hemostatic system is pivotal to maintaining vascular integrity. Multiple components involved in blood coagulation have central functions in inflammation…”
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Protein S levels modulate the activated protein C resistance phenotype induced by elevated prothrombin levels by Brugge, Jeroen M, Tans, Guido, Rosing, Jan, Castoldi, Elisabetta

“…Elevated plasma prothrombin levels, due to the prothrombin 20210 G/A mutation or to acquired causes, are a risk factor for venous thrombosis, partly because of…”
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Increased frequency of the homozygous II ACE genotype in Italian Olympic endurance athletes by Scanavini, Daniela, Bernardi, Francesco, Castoldi, Elisabetta, Conconi, Francesco, Mazzoni, Gianni

“…EUROPEAN JOURNAL OF HUMAN GENETICS: (2002) 10, 576-577. doi:10.1038/sj.ejhg.5200852…”
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Mutations in the R2 FV gene affect the ratio between the two FV isoforms in plasma by Castoldi, E, Rosing, J, Girelli, D, Hoekema, L, Lunghi, B, Mingozzi, F, Ferraresi, P, Friso, S, Corrocher, R, Tans, G, Bernardi, F

“…Molecular genetics and biochemical studies were performed in homozygotes for the R2 allele (4070G) in the factor V gene, most of them affected by coronary…”
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Post-transcriptional control of haemostatic genes: mechanisms and emerging therapeutic concepts in thrombo-inflammatory disorders by Danckwardt, Sven, Trégouët, David-Alexandre, Castoldi, Elisabetta

“…Abstract The haemostatic system is pivotal to maintaining vascular integrity. Multiple components involved in blood coagulation have central functions in…”
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