Search Results - "Castner, Stacy A."

Tuning the engine of cognition: A focus on NMDA/D1 receptor interactions in prefrontal cortex by Castner, Stacy A., Williams, Graham V.

“…The prefrontal cortex of the primate frontal lobes provides the capacity for judgment which can constantly adapt behavior in order to optimize its outcome…”
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Characterization of PF-6142, a Novel, Non-Catecholamine Dopamine Receptor D1 Agonist, in Murine and Nonhuman Primate Models of Dopaminergic Activation by Kozak, Rouba, Kiss, Tamás, Dlugolenski, Keith, Johnson, David E., Gorczyca, Roxanne R., Kuszpit, Kyle, Harvey, Brian D., Stolyar, Polina, Sukoff Rizzo, Stacey J., Hoffmann, William E., Volfson, Dmitri, Hajós, Mihaly, Davoren, Jennifer E., Abbott, Amanda L., Williams, Graham V., Castner, Stacy A., Gray, David L.

“…Selective activation of dopamine D1 receptors remains a promising pro-cognitive therapeutic strategy awaiting robust clinical investigation. PF-6142 is a key…”
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Reversal of Antipsychotic-Induced Working Memory Deficits by Short-Term Dopamine D1 Receptor Stimulation by Castner, Stacy A., Williams, Graham V., Goldman-Rakic, Patricia S.

“…Chronic blockade of dopamine D2 receptors, a common mechanism of action for antipsychotic drugs, down-regulates D1 receptors in the prefrontal cortex and, as…”
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Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia by Krystal, John H., Tolin, David F., Sanacora, Gerard, Castner, Stacy A., Williams, Graham V., Aikins, Deane E., Hoffman, Ralph E., D'Souza, D. Cyril

“…Current treatments for psychiatric disorders were developed with the aim of providing symptomatic relief rather than reversing underlying abnormalities in…”
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Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction by Roberts, Brooke M., Holden, Daniel E., Shaffer, Christopher L., Seymour, Patricia A., Menniti, Frank S., Schmidt, Christopher J., Williams, Graham V., Castner, Stacy A.

“…Working memory impairments are a core aspect of schizophrenia, yet current medicines do not address such cognitive dysfunction. We have developed a model of…”
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Amphetamine Sensitization Alters Dendritic Morphology in Prefrontal Cortical Pyramidal Neurons in the Non-Human Primate by SELEMON, Lynn D, BEGOVIC, Anita, GOLDMAN-RAKIC, Patricia S, CASTNER, Stacy A

“…Amphetamine (AMPH) sensitization in the nonhuman primate induces persistent aberrant behaviors reminiscent of the hallmark symptoms of schizophrenia, including…”
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Effects of DPTQ, a novel positive allosteric modulator of the dopamine D1 receptor, on spontaneous eye blink rate and spatial working memory in the nonhuman primate by Castner, Stacy A., Zhang, Linli, Yang, Charles R., Hao, Junliang, Cramer, Jeffrey W., Wang, Xushan, Bruns, Robert F., Marston, Hugh, Svensson, Kjell A., Williams, Graham V.

“…Rationale Dopamine (DA) signaling through the D1 receptor has been shown to be integral to multiple aspects of cognition, including the core process of working…”
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Reduction of brain kynurenic acid improves cognitive function by Kozak, Rouba, Campbell, Brian M, Strick, Christine A, Horner, Weldon, Hoffmann, William E, Kiss, Tamas, Chapin, Douglas S, McGinnis, Dina, Abbott, Amanda L, Roberts, Brooke M, Fonseca, Kari, Guanowsky, Victor, Young, Damon A, Seymour, Patricia A, Dounay, Amy, Hajos, Mihaly, Williams, Graham V, Castner, Stacy A

“…The elevation of kynurenic acid (KYNA) observed in schizophrenic patients may contribute to core symptoms arising from glutamate hypofunction, including…”
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Longevity factor klotho enhances cognition in aged nonhuman primates by Castner, Stacy A, Gupta, Shweta, Wang, Dan, Moreno, Arturo J, Park, Cana, Chen, Chen, Poon, Yan, Groen, Aaron, Greenberg, Kenneth, David, Nathaniel, Boone, Tom, Baxter, Mark G, Williams, Graham V, Dubal, Dena B

“…Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant…”
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Enhancement of Working Memory in Aged Monkeys by a Sensitizing Regimen of Dopamine D1 Receptor Stimulation by Castner, Stacy A, Goldman-Rakic, Patricia S

“…A natural consequence of aging is a loss of dopamine function and associated deficits in working memory in both human and nonhuman primates. Specifically,…”
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Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction by GOLDMAN-RAKIC, Patricia S, CASTNER, Stacy A, SVENSSON, Torgny H, SIEVER, Larry J, WILLIAMS, Graham V

“…Reinstatement of the function of working memory, the cardinal cognitive process essential for human reasoning and judgment, is potentially the most intractable…”
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Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia by Castner, Stacy A, Goldman-Rakic, Patricia S, Williams, Graham V

“…Working memory performance is considered to be a core deficit in schizophrenia and the best predictor of social reintegration and propensity for relapse. This…”
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Cognitive Consequences of Alterations in Functional Circuitry Induced by Chronic Cocaine Use and the Potential Impact for Treatment by Castner, Stacy A, Williams, Graham V

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Amelioration of ketamine-induced working memory deficits by dopamine D1 receptor agonists by Roberts, Brooke M., Seymour, Patricia A., Schmidt, Christopher J., Williams, Graham V., Castner, Stacy A.

“…Rationale Ketamine has been used in humans to model cardinal symptoms of schizophrenia, including working memory impairments and behavioral disorganization…”
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Reversal of Ketamine-Induced Working Memory Impairments by the GABAAα2/3 Agonist TPA023 by Castner, Stacy A, Arriza, Jeffrey L, Roberts, John C, Mrzljak, Ladislav, Christian, Edward P, Williams, Graham V

“…Background Ketamine has been used to model cognitive and behavioral symptoms of schizophrenia. Current hypotheses state that inadequate glutamatergic…”
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Glycine transporter inhibition reverses ketamine-induced working memory deficits by Roberts, Brooke M, Shaffer, Christopher L, Seymour, Patricia A, Schmidt, Christopher J, Williams, Graham V, Castner, Stacy A

“…Glycine transporter inhibitors have recently been reported to improve symptoms in patients with schizophrenia. Here we used acute ketamine in the nonhuman…”
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From vice to virtue: Insights from sensitization in the nonhuman primate by Castner, Stacy A., Williams, Graham V.

“…Repeated, intermittent administration of psychomotor stimulants, or D1 agonists in dopamine-deficient states, induces behavioral sensitization, characterized…”
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Amphetamine sensitization impairs cognition and reduces dopamine turnover in primate prefrontal cortex by Castner, Stacy A., Vosler, Peter S., Goldman-Rakic, Patricia S.

“…Amphetamine (AMPH) sensitization in monkeys produces long-lasting behavioral changes that model positive (hallucinatory-like behaviors) and negative…”
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Immediate and Sustained Improvements in Working Memory After Selective Stimulation of α7 Nicotinic Acetylcholine Receptors by Castner, Stacy A, Smagin, Gennady N, Piser, Timothy M, Wang, Yi, Smith, Jeffrey S, Christian, Edward P, Mrzljak, Ladislav, Williams, Graham V

“…Background Nicotine improves cognition in humans and animal models of neuropsychiatric disorders. Here, we sought to establish whether selective stimulation of…”
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Reversal of neuronal and cognitive consequences of amphetamine sensitization following chronic treatment with a D1 antagonist by Selemon, Lynn D., Begović, Anita, Williams, Graham V., Castner, Stacy A.

“…Neuroplasticity is a key factor in restoration of brain function following neuropathology associated with disease or drug exposure. Here we examined the…”
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