Search Results - "Castleden, S."

Targeted gene therapy for cancer: herpes simplex virus thymidine kinase gene-mediated cell killing leads to anti-tumour immunity that can be augmented by co-expression of cytokines in the tumour cells by Vile, R G, Diaz, R M, Castleden, S, Chong, H

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Individual Nuclei Differ in Their Sensitivity to the Cytoplasmic Inducers of DNA Synthesis: Implications for the Origin of Cell Cycle Variability by Hola, M., Howard, M., Nawaz, F.N., Castleden, S., Brooks, R.F.

“…Nuclei of multinucleate cells generally initiate DNA synthesis simultaneously, suggesting that the timing of DNA synthesis depends upon the appearance of a…”
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Initiation of DNA synthesis by nuclei from scrape-ruptured quiescent mammalian cells in high-speed supernatants of Xenopus egg extracts by Hola, M, Castleden, S, Howard, M, Brooks, R F

“…Demembranated sperm heads, detergent-isolated somatic nuclei and even naked DNA are efficiently replicated in cytoplasmic extracts of activated amphibian eggs,…”
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A family of bicistronic vectors to enhance both local and systemic antitumor effects of HSVtk or cytokine expression in a murine melanoma model by Castleden, S A, Chong, H, Garcia-Ribas, I, Melcher, A A, Hutchinson, G, Roberts, B, Hart, I R, Vile, R G

“…The herpes simplex virus-thymidine kinase/ganciclovir (HSVtk/GCV) system produces both direct and immune-mediated tumor cell killing. Here, we compare the…”
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Generation of an anti‐tumour immune response in a non‐immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1‐like profile of intratumoural cytokine expression by Vile, Richard G., Castleden, Simon, Marshall, John, Camplejohn, Richard, Upton, Carol, Chong, Heung

“…Direct delivery of the herpes simplex virus thymidine kinase (HSVtk) gene, in combination with the prodrug ganciclovir (GC), has been used for the treatment of…”
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Quantitative examination of thin-layer chromatography plates by photoacoustic spectroscopy by Castleden, S. L, Elliott, C. M, Kirkbright, G. F, Spillane, D. E. M

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Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component by VILE, R. G, NELSON, J. A, CASTLEDEN, S, HEUNG CHONG, HART, I. R

“…Previously we have demonstrated safe and effective transfer of the HSVtk cytotoxic gene to primary murine melanoma tumors by direct injection of plasmid and…”
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Wavelength modulation in photoacoustic spectroscopy by Castleden, S. L, Kirkbright, G. F, Spillane, D. E. M

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Retroviral vectors : From laboratory tools to molecular medicines by VILE, R. G, TUSZYNSKI, A, CASTLEDEN, S

“…The majority of clinical trials for gene therapy currently employ retroviral-mediated gene delivery. This is because the life cycle of the retrovirus is well…”
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Retroviral vectors. From laboratory tools to molecular medicine by Vile, R G, Tuszynski, A, Castleden, S

“…The majority of clinical trials for gene therapy currently employ retroviral-mediated gene delivery. This is because the life cycle of the retrovirus is well…”
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37 Combination gene therapies for the treatment of malignant melanoma in vivo by Vilea, R., Chong, Heung, Diaz, R.M., Hart, I., Castleden, S., Tuszynski, A.

“…For in vivo gene delivery, we have used the murine tyrosinase promoter to restrict expression of genes to melanoma cells. These genes are aimed either at…”
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Some spectroscopic observations of microwave and radio frequency plasmas by Castleden, S L

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