Search Results - "Castle, Jemma"

PCR amplicons identify widespread copy number variation in human centromeric arrays and instability in cancer by de Lima, Leonardo Gomes, Howe, Edmund, Singh, Vijay Pratap, Potapova, Tamara, Li, Hua, Xu, Baoshan, Castle, Jemma, Crozier, Steve, Harrison, Christine J., Clifford, Steve C., Miga, Karen H., Ryan, Sarra L., Gerton, Jennifer L.

“…Centromeric α-satellite repeats represent ∼6% of the human genome, but their length and repetitive nature make sequencing and analysis of those regions…”
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Mild uncoupling of mitochondria synergistically enhances senolytic specificity and sensitivity of BH3 mimetics by Miwa, Satomi, Fielder, Edward, Ishaq, Abbas, Low, Evon, Calista, Aisha, Castle, Jemma, von Zglinicki, Thomas

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PATH-06. Molecular subgrouping of medulloblastoma via low-depth whole genome bisulfite sequencing by Thompson, Dean, Castle, Jemma, Hicks, Debbie, Schwalbe, Ed, Clifford, Steve

“…Abstract INTRODUCTION: International consensus recognises four molecular subgroups of medulloblastoma, each with distinct molecular features and clinical…”
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OMIC-06. MOLECULAR SUBGROUPING OF MEDULLOBLASTOMA VIA LOW-DEPTH WHOLE GENOME BISULFITE SEQUENCING by Thompson, Dean, Castle, Jemma, Hicks, Debbie, Clifford, Steve, Schwalbe, Ed

“…Abstract Introduction International consensus recognises four molecular subgroups of medulloblastoma, each with distinct molecular features and clinical…”
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QOL-04.IN VIVO MODELLING RECAPITULATES RADIOTHERAPY DELIVERY AND LATE-EFFECT PROFILE FOR CHILDHOOD MEDULLOBLASTOMA by Castle, Jemma, Shaw, Gary, Weller, Dominic, Fielder, Edward, Egnuni, Teklu, Singh, Mankaran, Skinner, Roderick, von Zglinicki, Thomas, Clifford, Steven C, Short, Susan, Miwa, Satomi, Hicks, Debbie

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Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development by Williamson, Daniel, Schwalbe, Edward C., Hicks, Debbie, Aldinger, Kimberly A., Lindsey, Janet C., Crosier, Stephen, Richardson, Stacey, Goddard, Jack, Hill, Rebecca M., Castle, Jemma, Grabovska, Yura, Hacking, James, Pizer, Barry, Wharton, Stephen B., Jacques, Thomas S., Joshi, Abhijit, Bailey, Simon, Clifford, Steven C.

“…Medulloblastoma is currently subclassified into distinct DNA methylation subgroups/subtypes with particular clinico-molecular features. Using RNA sequencing…”
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Molecular and clinical heterogeneity within MYC-family amplified medulloblastoma is associated with survival outcomes: A multicenter cohort study by Schwalbe, Edward C, Lindsey, Janet C, Danilenko, Marina, Hill, Rebecca M, Crosier, Stephen, Ryan, Sarra L, Williamson, Daniel, Castle, Jemma, Hicks, Debbie, Kool, Marcel, Milde, Till, Korshunov, Andrey, Pfister, Stefan M, Bailey, Simon, Clifford, Steven C

“…MYC/MYCN are the most frequent oncogene amplifications in medulloblastoma (MB) and its primary biomarkers of high-risk (HR) disease. However, while many…”
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MDB-75. MOLECULAR PATHOLOGY, TREATMENT AND PROGNOSIS OF INFANT SONIC HEDGEHOG MEDULLOBLASTOMA: A GLOBAL MULTI-COHORT STUDY by Richardson, Stacey, Hicks, Debbie, Gough, Melissa, Castle, Jemma, Crosier, Stephen, Garcia-Ariza, Miguel, Martín-Guerrero, Idoia, LA Plasschaert, Sabine, Bourdeaut, Franck, Dufour, Christelle, Masliah-Planchon, Julien, Buttarelli, Francesca R, Garre, Maria-Luisa, Biassoni, Veronica, Massimino, Maura, Kanemura, Yonehiro, Ramaswamy, Vijay, Gajjar, Amar, Northcott, Paul, Robinson, Giles, Korshunov, Andrey, Pfister, Stefan M, Mynarek, Martin, Rutkowski, Stefan, Schwalbe, Edward C, Bailey, Simon, Clifford, Steven C

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Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification by Goddard, Jack, Castle, Jemma, Southworth, Emily, Fletcher, Anya, Crosier, Stephen, Martin-Guerrero, Idoia, García-Ariza, Miguel, Navajas, Aurora, Masliah-Planchon, Julien, Bourdeaut, Franck, Dufour, Christelle, Ayrault, Olivier, Goschzik, Tobias, Pietsch, Torsten, Sill, Martin, Pfister, Stefan M., Rutkowski, Stefan, Richardson, Stacey, Hill, Rebecca M., Williamson, Daniel, Bailey, Simon, Schwalbe, Edward C., Clifford, Steven C., Hicks, Debbie

“…Group 4 tumours (MB Grp4 ) represent the majority of non-WNT/non-SHH medulloblastomas. Their clinical course is poorly predicted by current risk-factors. MB…”
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QOL-28. Clinico-molecular correlates of quality of survival and neurocognitive outcomes in medulloblastoma; a meta-analysis of the SIOP-UKCCSG-PNET3 and HIT-SIOP-PNET4 trials by Chevignard, Mathilde, Bull, Kim S, Holt, James, Harrington, Bertie, Castle, Jemma, Heng, Marie-Amelie, Kennedy, Colin, Doz, Francois, Lannering, Birgitta, Rutkowski, Stefan, Massimino, Maura, Bailey, Simon, Oyefiade, Adeoye, Mabbott, Donald, Clifford†, Steven C, Hicks†, Debbie

“…Abstract Determinants of survivorship outcomes are emerging from limited studies of medulloblastoma (MB) survivors. We undertook an integrated analysis of…”
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EMBR-25. GENOME-WIDE GENETIC AND EPIGENETIC ASSESSMENT OF GROUP 4 MEDULLOBLASTOMA FOR IMPROVED, BIOMARKER DRIVEN, PROGNOSTICATION AND RISK-STRATIFICATION by Goddard, Jack, Castle, Jemma, Southworth, Emily, Crosier, Stephen, Martin-Guerrero, Idoia, Garcia-Ariza, Miguel, Navajas, Aurora, Bourdeaut, Franck, Dufour, Christelle, Goschzik, Tobias, Pietsch, Torsten, Williamson, Dan, Bailey, Simon, Schwalbe, Ed, Clifford, Steven, Hicks, Debbie

“…Abstract Introduction Medulloblastoma (MB) is the most common malignant brain tumour in children. The most frequent molecular subgroup, Group 4 (MBGrp4)…”
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MEDB-71. Molecular characterisation of group 4 medulloblastoma improves risk-stratification and its biological understanding by Goddard, Jack, Castle, Jemma, Southworth, Emily, Fletcher, Anya, Crosier, Stephen, Martin-Guerrero, Idoia, Garcia-Ariza, Miguel, Navajas, Aurora, Masliah-Planchon, Julien, Bourdeaut, Franck, Dufour, Christelle, Goschizk, Tobias, Pietsch, Torsten, Richardson, Stacey, Hill, Rebecca M, Williamson, Daniel, Bailey, Simon, Schwalbe, Edward C, Clifford, Steven C, Hicks, Debbie

“…Abstract Group 4 (MBGrp4) accounts for ~40% of medulloblastoma and the majority of non-WNT/non-SHH cases, yet its underpinning biology is poorly understood,…”
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In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma by Castle, Jemma, Shaw, Gary, Weller, Dominic, Fielder, Edward, Egnuni, Teklu, Singh, Mankaran, Skinner, Roderick, von Zglinicki, Thomas, Clifford, Steven C, Short, Susan C, Miwa, Satomi, Hicks, Debbie

“…Abstract Background Medulloblastoma (MB) is the most common malignant pediatric brain tumor, with 5-year survival rates > 70%. Cranial radiotherapy (CRT) to…”
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