Search Results - "Castle, C."

Actively personalized vaccination trial for newly diagnosed glioblastoma by Hilf, Norbert, Kuttruff-Coqui, Sabrina, Frenzel, Katrin, Bukur, Valesca, Stevanović, Stefan, Gouttefangeas, Cécile, Platten, Michael, Tabatabai, Ghazaleh, Dutoit, Valerie, van der Burg, Sjoerd H., thor Straten, Per, Martínez-Ricarte, Francisco, Ponsati, Berta, Okada, Hideho, Lassen, Ulrik, Admon, Arie, Ottensmeier, Christian H., Ulges, Alexander, Kreiter, Sebastian, von Deimling, Andreas, Skardelly, Marco, Migliorini, Denis, Kroep, Judith R., Idorn, Manja, Rodon, Jordi, Piró, Jordi, Poulsen, Hans S., Shraibman, Bracha, McCann, Katy, Mendrzyk, Regina, Löwer, Martin, Stieglbauer, Monika, Britten, Cedrik M., Capper, David, Welters, Marij J. P., Sahuquillo, Juan, Kiesel, Katharina, Derhovanessian, Evelyna, Rusch, Elisa, Bunse, Lukas, Song, Colette, Heesch, Sandra, Wagner, Claudia, Kemmer-Brück, Alexandra, Ludwig, Jörg, Castle, John C., Schoor, Oliver, Tadmor, Arbel D., Green, Edward, Fritsche, Jens, Meyer, Miriam, Pawlowski, Nina, Dorner, Sonja, Hoffgaard, Franziska, Rössler, Bernhard, Maurer, Dominik, Weinschenk, Toni, Reinhardt, Carsten, Huber, Christoph, Rammensee, Hans-Georg, Singh-Jasuja, Harpreet, Sahin, Ugur, Dietrich, Pierre-Yves, Wick, Wolfgang

“…Patients with glioblastoma currently do not sufficiently benefit from recent breakthroughs in cancer treatment that use checkpoint inhibitors 1 , 2 . For…”
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Clinical Relevance of Age-Related Immune Dysfunction by Castle, Steven C.

“…Immunosenescence is the state of dysregulated immune function that contributes to the increased susceptibility to infection of the elderly. Extensive studies…”
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Mutation-Derived Neoantigens for Cancer Immunotherapy by Castle, John C, Uduman, Mohamed, Pabla, Simarjot, Stein, Robert B, Buell, Jennifer S

“…Mutation-derived neoantigens distinguish tumor from normal cells. T cells can sense the HLA-presented mutations, recognize tumor cells as non-self and destroy…”
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Exploiting the Mutanome for Tumor Vaccination by CASTLE, John C, KREITER, Sebastian, KOSLOWSKI, Michael, KUHN, Andreas N, BRITTEN, Cedrik M, HUBER, Christoph, TÜRECI, Ozlem, SAHIN, Ugur, DIEKMANN, Jan, LÖWER, Martin, DE ROEMER, Niels Van, DE GRAAF, Jos, SELMI, Abderraouf, DIKEN, Mustafa, BOEGEL, Sebastian, PARET, Claudia

“…Multiple genetic events and subsequent clonal evolution drive carcinogenesis, making disease elimination with single-targeted drugs difficult. The multiplicity…”
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Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma by Castle, John C, Loewer, Martin, Boegel, Sebastian, de Graaf, Jos, Bender, Christian, Tadmor, Arbel D, Boisguerin, Valesca, Bukur, Thomas, Sorn, Patrick, Paret, Claudia, Diken, Mustafa, Kreiter, Sebastian, Türeci, Özlem, Sahin, Ugur

“…Tumor models are critical for our understanding of cancer and the development of cancer therapeutics. Here, we present an integrated map of the genome,…”
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Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models by Genoud, Vassilis, Marinari, Eliana, Nikolaev, Sergey I, Castle, John C, Bukur, Valesca, Dietrich, Pierre-Yves, Okada, Hideho, Walker, Paul R

“…Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results…”
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Nutrient addition dramatically accelerates microbial community succession by Knelman, Joseph E, Schmidt, Steven K, Lynch, Ryan C, Darcy, John L, Castle, Sarah C, Cleveland, Cory C, Nemergut, Diana R

“…The ecological mechanisms driving community succession are widely debated, particularly for microorganisms. While successional soil microbial communities are…”
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HLA and proteasome expression body map by Boegel, Sebastian, Löwer, Martin, Bukur, Thomas, Sorn, Patrick, Castle, John C, Sahin, Ugur

“…The presentation of HLA peptide complexes to T cells is a highly regulated and tissue specific process involving multiple transcriptionally controlled cellular…”
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Nutrient limitation of soil microbial activity during the earliest stages of ecosystem development by Castle, Sarah C., Sullivan, Benjamin W., Knelman, Joseph, Hood, Eran, Nemergut, Diana R., Schmidt, Steven K., Cleveland, Cory C.

“…A dominant paradigm in ecology is that plants are limited by nitrogen (N) during primary succession. Whether generalizable patterns of nutrient limitation are…”
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Arts activity and well-being for visually impaired military veterans: a narrative discussion of current knowledge by Castle, C.L., Engward, H., Kersey, T.

“…The objective of this study was to offer an overview of literature relating to the topic of arts as activity within the context of military and veteran health…”
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Angiosarcoma patients treated with immune checkpoint inhibitors: a case series of seven patients from a single institution by Florou, Vaia, Rosenberg, Andrew E, Wieder, Eric, Komanduri, Krishna V, Kolonias, Despina, Uduman, Mohamed, Castle, John C, Buell, Jennifer S, Trent, Jonathan C, Wilky, Breelyn A

“…Angiosarcoma is an uncommon endothelial malignancy and a highly aggressive soft tissue sarcoma. Due to its infiltrative nature, successful management of…”
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A Postnatal Switch of CELF and MBNL Proteins Reprograms Alternative Splicing in the Developing Heart by Kalsotra, Auinash, Xiao, Xinshu, Ward, Amanda J., Castle, John C., Johnson, Jason M., Burge, Christopher B., Cooper, Thomas A.

“…From a large-scale screen using splicing microarrays and RT-PCR, we identified 63 alternative splicing (AS) events that are coordinated in 3 distinct temporal…”
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Genome-scale RNAi screen for host factors required for HIV replication by Zhou, Honglin, Xu, Min, Huang, Qian, Gates, Adam T, Zhang, Xiaohua D, Castle, John C, Stec, Erica, Ferrer, Marc, Strulovici, Berta, Hazuda, Daria J, Espeseth, Amy S

“…Human immunodeficiency virus (HIV)-1 depends on the host cell machinery to support its replication. To discover cellular factors associated with HIV-1…”
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Assessing nutrient limitation in complex forested ecosystems: alternatives to large-scale fertilization experiments by Sullivan, Benjamin W, Alvarez-Clare, Silvia, Castle, Sarah C, Porder, Stephen, Reed, Sasha C, Schreeg, Laura, Townsend, Alan R, Cleveland, Cory C

“…Quantifying nutrient limitation of primary productivity is a fundamental task of terrestrial ecosystem ecology, but in a high carbon dioxide environment it is…”
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Association between HIV and Prevalent Hypertension and Diabetes Mellitus in South Africa: Analysis of a Nationally Representative Cross-Sectional Survey by Magodoro, Itai M., Okello, Samson, Dungeni, Mongiwethu, Castle, Alison C., Mureyani, Shakespeare, Danaei, Goodarz

“…•Cardiometabolic diseases increasingly prominent in HIV in low and middle-income countries (LMICs) such as South Africa.•Unclear if this reflects absolute risk…”
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Modulating Cell Fate as a Therapeutic Strategy by Lin, Brian, Srikanth, Priya, Castle, Alison C., Nigwekar, Sagar, Malhotra, Rajeev, Galloway, Jenna L., Sykes, David B., Rajagopal, Jayaraj

“…In injured tissues, regeneration is often associated with cell fate plasticity, in that cells deviate from their normal lineage paths. It is becoming…”
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SNPs occur in regions with less genomic sequence conservation by Castle, John C

“…Rates of SNPs (single nucleotide polymorphisms) and cross-species genomic sequence conservation reflect intra- and inter-species variation, respectively. Here,…”
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Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines by Castle, John C, Johnson, Jason M, Zhang, Chaolin, Shah, Jyoti K, Kulkarni, Amit V, Kalsotra, Auinash, Cooper, Thomas A

“…Jason Johnson and colleagues present the first genome-scale compendium of human alternative splicing events in 48 tissues. These data constitute a rich…”
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OCAMS: The OSIRIS-REx Camera Suite by Rizk, B., Drouet d’Aubigny, C., Golish, D., Fellows, C., Merrill, C., Smith, P., Walker, M. S., Hendershot, J. E., Hancock, J., Bailey, S. H., DellaGiustina, D. N., Lauretta, D. S., Tanner, R., Williams, M., Harshman, K., Fitzgibbon, M., Verts, W., Chen, J., Connors, T., Hamara, D., Dowd, A., Lowman, A., Dubin, M., Burt, R., Whiteley, M., Watson, M., McMahon, T., Ward, M., Booher, D., Read, M., Williams, B., Hunten, M., Little, E., Saltzman, T., Alfred, D., O’Dougherty, S., Walthall, M., Kenagy, K., Peterson, S., Crowther, B., Perry, M. L., See, C., Selznick, S., Sauve, C., Beiser, M., Black, W., Pfisterer, R. N., Lancaster, A., Oliver, S., Oquest, C., Crowley, D., Morgan, C., Castle, C., Dominguez, R., Sullivan, M.

“…The OSIRIS-REx Camera Suite (OCAMS) will acquire images essential to collecting a sample from the surface of Bennu. During proximity operations, these images…”
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A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines by Boegel, Sebastian, Löwer, Martin, Bukur, Thomas, Sahin, Ugur, Castle, John C

“…Cancer cell lines are a tremendous resource for cancer biology and therapy development. These multipurpose tools are commonly used to examine the genetic…”
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