Search Results - "Castino, R"

Inhibition of histone deacetylases facilitates extinction and attenuates reinstatement of nicotine self-administration in rats by Castino, Matthew R, Cornish, Jennifer L, Clemens, Kelly J

“…Chromatin remodelling is integral to the formation of long-term memories. Recent evidence suggests that histone modification may play a role in the persistence…”
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Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D by Trincheri, Nicol F., Nicotra, Giuseppina, Follo, Carlo, Castino, Roberta, Isidoro, Ciro

“…In human colorectal cancer cells, the polyphenol resveratrol (RV) activated the caspase-dependent intrinsic pathway of apoptosis. This effect was not mediated…”
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DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity by Fortini, P, Ferretti, C, Pascucci, B, Narciso, L, Pajalunga, D, Puggioni, E M R, Castino, R, Isidoro, C, Crescenzi, M, Dogliotti, E

“…DNA single-strand breaks (SSB) formation coordinates the myogenic program, and defects in SSB repair in post-mitotic cells have been associated with human…”
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Cathepsin D–Bax death pathway in oxidative stressed neuroblastoma cells by Castino, Roberta, Bellio, Natascia, Nicotra, Giuseppina, Follo, Carlo, Trincheri, Nicol F., Isidoro, Ciro

“…Hydrogen peroxide, the major oxidoradical species in the central nervous system, has been involved in neuronal cell death and associated neurodegenerative…”
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Akt Induces Apoptosis in Neuroblastoma Cells Expressing a C98X Vasopressin Mutant Following Autophagy Suppression by Castino, R., Thepparit, C., Bellio, N., Murphy, D., Isidoro, C.

“…Mutations in the arginine vasopressin (AVP)‐neurophysin II (NP‐II) gene that affect the folding and transport of the prohormone result in loss of secretion of…”
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1061 Transgenic Expression of Wild-type or Phosphatase-deficient Mutant PTEN Restores Sensitivity to Resveratrol in PTEN-deficient Ovarian Cancer Cells by Titone, R, Morani, F, Veneroni, R, Castino, R, Peracchio, C, Giovia, A, Follo, C, Isidoro, C

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Cathepsin D released by lactating rat mammary epithelial cells is involved in prolactin cleavage under physiological conditions by Lkhider, Mustapha, Castino, Roberta, Bouguyon, Edwige, Isidoro, Ciro, Ollivier-Bousquet, Michèle

“…The 16 kDa prolactin fragment arises from partial proteolysis of the native 23 kDa prolactin pituitary hormone. The mammary gland has been involved in this…”
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A role for a novel natural antisense-BDNF in the maintenance of nicotine-seeking by Youngson, Neil A., Castino, Matthew R., Stuart, Angela, Kershaw, Kelly A., Holmes, Nathan M., Heffernan, Eilish C., Waters, Paul D., Morris, Kevin V., Clemens, Kelly J.

“…•We describe a natural antisense transcript opposite exon-IV of the Bdnf gene.•AS-BDNF-IV is increased following self- but not experimenter-administered…”
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Behavioral and neural substrates of habit formation in rats intravenously self-administering nicotine by Clemens, Kelly J, Castino, Matthew R, Cornish, Jennifer L, Goodchild, Ann K, Holmes, Nathan M

“…Tobacco addiction involves a transition from occasional, voluntary smoking towards habitual behavior that becomes increasingly resistant to quitting. The…”
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Multiple Properties of Drug-Paired Cues May Precipitate Reinstatement by Castino, Matthew R, Khoo, Shaun Yon-Seng

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Persistent histone modifications at the BDNF and Cdk‐5 promoters following extinction of nicotine‐seeking in rats by Castino, M. R., Baker‐Andresen, D., Ratnu, V. S., Shevchenko, G., Morris, K. V., Bredy, T. W., Youngson, N. A., Clemens, K. J.

“…Nicotine self‐administration leads to persistent alterations in histone methylation at brain‐derived neurotrophic factor IV and Cdk‐5 promoters. Drugs of…”
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The lysosomal protease cathepsin D is efficiently sorted to and secreted from regulated secretory compartments in the rat basophilic/mast cell line RBL by Dragonetti, A, Baldassarre, M, Castino, R, Démoz, M, Luini, A, Buccione, R, Isidoro, C

“…Basophils and mast cells contain a peculiar class of inflammatory granules that discharge their content upon antigen-mediated crosslinking of IgE-membrane…”
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Autophagy-dependent cell survival and cell death in an autosomal dominant familial neurohypophyseal diabetes insipidus in vitro model by Castino, Roberta, Isidoro, Ciro, Murphy, David

“…ABSTRACTMutations in the human gene encoding the antidiuretic hormone vasopressin (VP) cause autosomal dominant familial neurohypophyseal diabetes insipidus…”
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Destination 'Lysosome': a target organelle for tumour cell killing? by Castino, Roberta, Démoz, Marina, Isidoro, Ciro

“…Lysosomes and lysosome‐related organelles constitute a system of acid compartments that interconnect the inside of the cell with the extracellular environment…”
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The expression of prolactin and its cathepsin D-mediated cleavage in the bovine corpus luteum vary with the estrous cycle by Erdmann, Sabine, Ricken, Albert, Merkwitz, Claudia, Struman, Ingrid, Castino, Roberta, Hummitzsch, Katja, Gaunitz, Frank, Isidoro, Ciro, Martial, Joseph, Spanel-Borowski, Katharina

“…In the corpus luteum (CL), blood vessels develop, stabilize, and regress. This process depends on the ratio of pro- and antiangiogenic factors, which change…”
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Autophagy is a prosurvival mechanism in cells expressing an autosomal dominant familial neurohypophyseal diabetes insipidus mutant vasopressin transgene by Castino, Roberta, Davies, Janet, Beaucourt, Stephanie, Isidoro, Ciro, Murphy, David

“…ABSTRACTAutosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is a progressive, inherited neurodegenerative disorder that presents as…”
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cFLIP expression correlates with tumour progression and patient outcome in non‐Hodgkin lymphomas of low grade of malignancy by Valente, Guido, Manfroi, Federica, Peracchio, Claudia, Nicotra, Giuseppina, Castino, Roberta, Nicosia, Gabriella, Kerim, Simonetta, Isidoro, Ciro

“…Summary The present study investigated whether the expression of cellular Fas‐associated death domain‐like interleukin‐1β‐converting enzyme (FLICE) inhibitory…”
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Preconditioning-induced cytoprotection in hepatocytes requires Ca2+-dependent exocytosis of lysosomes by Carini, Rita, Castino, Roberta, De Cesaris, Maria Grazia, Splendore, Roberta, Démoz, Marina, Albano, Emanuele, Isidoro, Ciro

“…A short period of hypoxia reduces the cytotoxicity produced by a subsequent prolonged hypoxia in isolated hepatocytes. This phenomenon, termed hypoxic…”
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Expression of protein kinase C beta 1 confers resistance to TNF alpha - and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells by Cesaro, P, Raiteri, E, Demoz, M, Castino, R, Baccino, F M, Bonelli, G, Isidoro, C

“…The expression of different protein kinase C (PKC) isoenzymes has been shown to vary with proliferation rates, differentiation or apoptosis in normal colon…”
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Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas by Castino, Roberta, Pace, Deborah, Démoz, Marina, Gargiulo, Marco, Ariatta, Chiara, Raiteri, Elisabetta, Isidoro, Ciro

“…Neuroblastoma is the most common type of cancer in infants. In children this tumor is particularly aggressive; despite various new therapeutic approaches, it…”
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