Human Epidemiology and Response to SARS-CoV-2 (HEROS): objectives, design, and enrollment results of a 12-city remote observational surveillance study of households with children, using direct-to-participant methods

The Human Epidemiology and Response to SARS-CoV-2 (HEROS) Study is a prospective, multicity, 6-month incidence study conducted from May 2020 to February 2021. The objectives were to identify risk factors for SARS-CoV-2 infection and household transmission among children and people with asthma and al...

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Bibliographic Details
Published in:	American journal of epidemiology Vol. 193; no. 10; pp. 1329 - 1338
Main Authors:	Fulkerson, Patricia C, Lussier, Stephanie J, Bendixsen, Casper G, Castina, Sharon M, Gebretsadik, Tebeb, Marlin, Jessica S, Russell, Patty B, Seibold, Max A, Everman, Jamie L, Moore, Camille M, Snyder, Brittney M, Thompson, Kathy, Tregoning, George S, Wellford, Stephanie, Arbes, Samuel J, Bacharier, Leonard B, Calatroni, Agustin, Camargo, Jr, Carlos A, Dupont, William D, Furuta, Glenn T, Gruchalla, Rebecca S, Gupta, Ruchi S, Hershey, Gurjit Khurana, Jackson, Daniel J, Johnson, Christine C, Kattan, Meyer, Liu, Andrew H, Murrison, Liza, O'Connor, George T, Phipatanakul, Wanda, Rivera-Spoljaric, Katherine, Rothenberg, Marc E, Seroogy, Christine M, Teach, Stephen J, Zoratti, Edward M, Togias, Alkis, Hartert, Tina V, Heros Study Team, On Behalf Of The
Format:	Journal Article
Language:	English
Published:	United States 07-10-2024
Subjects:	Adolescent Adult Asthma - epidemiology Child Child, Preschool COVID-19 - epidemiology COVID-19 - transmission Family Characteristics Female Humans Infant Male Middle Aged Prospective Studies Research Design Risk Factors SARS-CoV-2 United States - epidemiology Young Adult United States COVID-19 remote methods surveillance public health
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Summary:	The Human Epidemiology and Response to SARS-CoV-2 (HEROS) Study is a prospective, multicity, 6-month incidence study conducted from May 2020 to February 2021. The objectives were to identify risk factors for SARS-CoV-2 infection and household transmission among children and people with asthma and allergic diseases, and to use the host nasal transcriptome sampled longitudinally to understand infection risk and sequelae at the molecular level. To overcome challenges of clinical study implementation due to the coronavirus pandemic, this surveillance study used direct-to-participant methods to remotely enroll and prospectively follow eligible children who are participants in other National Institutes of Health-funded pediatric research studies and their household members. Households participated in weekly surveys and biweekly nasal sampling regardless of symptoms. The aim of this report is to widely share the methods and study instruments and to describe the rationale, design, execution, logistics, and characteristics of a large, observational, household-based, remote cohort study of SARS-CoV-2 infection and transmission in households with children. The study enrolled a total of 5598 individuals, including 1913 principal participants (children), 1913 primary caregivers, 729 secondary caregivers, and 1043 other household children. This study was successfully implemented without necessitating any in-person research visits and provides an approach for rapid execution of clinical research. Trial registration: ClinicalTrials.gov. Identifier: NCT04375761.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9262 1476-6256
DOI:	10.1093/aje/kwae077