Search Results - "Castillejo, J A"

Transcriptional silencing of the Dickkopfs-3 (Dkk-3) gene by CpG hypermethylation in acute lymphoblastic leukaemia by ROMAN-GOMEZ, J, JIMENEZ-VELASCO, A, AGIRRE, X, CASTILLEJO, J. A, NAVARRO, G, BARRIOS, M, ANDREU, E. J, PROSPER, F, HEINIGER, A, TORRES, A

“…DKK-3: is a newly characterised mortalisation-related gene and an antagonist of the Wnt oncogenic signalling pathway whose expression is decreased in a variety…”
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Reliable quantification of hematopoietic chimerism after allogeneic transplantation for acute leukemia using amplification by real-time PCR of null alleles and insertion deletion polymorphisms by JIMENEZ-VELASCO, A, BARRIOS, M, ROMAN-GOMEZ, J, NAVARRO, G, BUNO, I, CASTILLEJO, J. A, RODRIGUEZ, A. I, GARCIA-GEMAR, G, TORRES, A, HEINIGER, A. I

“…Increasing mixed chimerism (MC) after allogeneic stem cell transplantation (SCT) has been associated with a high risk of relapse in acute leukemia. We…”
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The normal epithelial cell-specific 1 ( ) gene, a candidate tumor suppressor gene on chromosome 19q13.3-4, is downregulated by hypermethylation in acute lymphoblastic leukemia by Roman-Gomez, J, Jimenez-Velasco, A, Agirre, X, Castillejo, J A, Barrios, M, Andreu, E J, Prosper, F, Heiniger, A, Torres, A

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Promoter hypermethylation and global hypomethylation are independent epigenetic events in lymphoid leukemogenesis with opposing effects on clinical outcome by Roman-Gomez, J, Jimenez-Velasco, A, Agirre, X, Castillejo, J A, Navarro, G, Garate, L, Jose-Eneriz, E San, Cordeu, L, Barrios, M, Prosper, F, Heiniger, A, Torres, A

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Increasing mixed haematopoietic chimaerism after BMT with total depletion of CD4+ and partial depletion of CD8+ lymphocytes is associated with a higher incidence of relapse by SERRANO, J, ROMAN, J, TORRES, A, HERRERA, C, CASTILLEJO, J. A, NAVARRO, J. A, REINA, M. L, GONZALEZ, M. G, RODRIGUEZ, M. C, PASCUAL, A, SANCHEZ, J

“…In this study we analysed the incidence and clinical impact of the persistence of host haemopoiesis (mixed chimaerism, MC) after allogeneic BMT in 35…”
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Retraction Note: Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia by Roman-Gomez, J, Jimenez-Velasco, A, Agirre, X, Cervantes, F, Sanchez, J, Garate, L, Barrios, M, Castillejo, J A, Navarro, G, Colomer, D, Prosper, F, Heiniger, A, Torres, A

“…The authors wish to retract the November 3, 2005, paper cited above. Figure 6a in the published manuscript was inappropriately reproduced from figure 1 in a…”
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Genetic, phenotypic and clinical features of acute lymphoblastic leukemias expressing myeloperoxidase mRNA detected by RT-PCR by SERRANO, J, ROMAN, J, JIMENEZ, A, CASTILLEJO, J. A, NAVARRO, J, SANCHEZ, J. M, GARCIA-CASTELLANOS, J, MARTIN, C, MALDONADO, J, TORRES, A

“…Myeloperoxidase (MPO) is found in the azurophilic granules of normal myelocytic cells. Cytochemical staining for MPO activity is used clinically to distinguish…”
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Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia by Roman-Gomez, J, Jimenez-Velasco, A, Agirre, X, Cervantes, F, Sanchez, J, Garate, L, Barrios, M, Castillejo, J.A, Navarro, G, Colomer, D, Prosper, F, Heiniger, A, Torres, A

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Autologous reconstitution with BCR-ABL-negative haematopoiesis after T cell-depleted allogeneic BMT for CML by SERRANO, J, ROMAN, J, CASTILLEJO, J. A, SANCHEZ, J, NAVARRO, J. A, MARTIN, C, HERRERA, C, TORRES, A

“…We report a patient with Ph chromosome-positive CML who underwent an HLA-identical T cell-depleted BMT from a sibling donor. DNA polymorphism analysis showed…”
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Myeloid mixed chimerism is associated with relapse in bcr-abl positive patients after unmanipulated allogeneic bone marrow transplantation for chronic myelogenous leukemia by Roman, J, Serrano, J, Jimenez, A, Castillejo, JA, Reina, ML, Gonzalez, MG, Rodriguez, MC, Garcia, I, Sanchez, J, Maldonado, J, Torres, A

“…Servicio de Hematologia, Hospital Reina Sofia, 14004 Cordoba, Spain. jose.roman@iname.com. BACKGROUND AND OBJECTIVE: Although bcr-abl polymerase chain reaction…”
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Chimerism analysis in long-term survivor patients after bone marrow transplantation for severe aplastic anemia by Gomez, , JR, Garcia, MJ, Serrano, J, Sanchez, J, Falcon, M, Castillejo, JA, Navarro, JA, Martin, C, Torres, A

“…Department of Hematology, Reina Sofia Hospital, Cordoba, Spain. BACKGROUND AND OBJECTIVE: Allogeneic bone marrow transplantation (BMT) is the most common…”
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Pyoderma gangrenosum associated with Fanconi's anemia by Serrano, J, Rojas, R, Sánchez, J, Falcón, M, Román, J, Castillejo, J A, Navarro, J A, Torres, A

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Hypermethylation of the calcitonin gene in acute lymphoblastic leukaemia is associated with unfavourable clinical outcome by Roman, Jose, Castillejo, Juan Antonio, Jimenez, Antonio, Bornstein, Rafael, Gonzalez, Maria Gracia, Del Carmen Rodriguez, Maria, Barrios, Manuel, Maldonado, Juan, Torres, Antonio

“…We analysed calcitonin (CALC1) gene hypermethylation using semiquantitative differential polymerase chain reaction in 105 patients with adult (n = 49) and…”
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E1A3 as a unique, naturally occurring BCR–ABL transcript in an indolent case of chronic myeloid leukaemia by Roman, Jose, Jimenez, Antonio, Barrios, Manuel, Castillejo, Juan Antonio, Maldonado, Juan, Torres, Antonio

“…A woman with Ph‐positive chronic myeloid leukaemia (CML) with an atypical e1a3 BCR–ABL hybrid gene is described. To our knowledge, this is the first report of…”
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Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia by Roman-Gomez, Jose, Jimenez-Velasco, Antonio, Agirre, Xabier, Castillejo, Juan A, Navarro, German, San Jose-Eneriz, Edurne, Garate, Leire, Cordeu, Lucia, Cervantes, Francisco, Prosper, Felipe, Heiniger, Anabel, Torres, Antonio

“…From the Hematology Department, Reina Sofia Hospital, Cordoba, Spain (JR-G, JAC, AT); Hematology Department, Carlos Haya Hospital, Malaga, Spain (AJ-V, GN,…”
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Molecular analysis of lineage-specific chimerism and minimal residual disease by RT-PCR of p210(BCR-ABL) and p190(BCR-ABL) after allogeneic bone marrow transplantation for chronic myeloid leukemia: increasing mixed myeloid chimerism and p190(BCR-ABL) detection precede cytogenetic relapse by Serrano, J, Roman, J, Sanchez, J, Jimenez, A, Castillejo, J A, Herrera, C, Gonzalez, M G, Reina, L, Rodriguez, M C, Alvarez, M A, Maldonado, J, Torres, A

“…We studied lineage-specific chimerism and minimal residual disease (MRD) in sequential posttransplant samples from 55 patients who underwent unmanipulated (n =…”
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Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense antisense transcription and marks the progression of chronic myeloid leukemia by ROMAN-GOMEZ, Jose, JIMENEZ-VELASCO, Antonio, PROSPER, Felipe, HEINIGER, Anabel, TORRES, Antonio, AGIRRE, Xabier, CERVANTES, Francisco, SANCHEZ, Joaquin, GARATE, Leire, BARRIOS, Manuel, CASTILLEJO, Juan A, NAVARRO, German, COLOMER, Dolors

“…Aberrant genome-wide hypomethylation is thought to be related to tumorigenesis by promoting genomic instability. Since DNA methylation is considered an…”
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Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia by Roman-Gomez, Jose, Jimenez-Velasco, Antonio, Castillejo, Juan A., Agirre, Xabier, Barrios, Manuel, Navarro, German, Molina, Francisco J., Calasanz, Maria J., Prosper, Felipe, Heiniger, Anabel, Torres, Antonio

“…Promoter hypermethylation plays an important role in the inactivation of cancer-related genes. This abnormality occurs early in leukemogenesis and seems to be…”
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WNT5A , a putative tumour suppressor of lymphoid malignancies, is inactivated by aberrant methylation in acute lymphoblastic leukaemia by Roman-Gomez, Jose, Jimenez-Velasco, Antonio, Cordeu, Lucia, Vilas-Zornoza, Amaia, San Jose-Eneriz, Edurne, Garate, Leire, Castillejo, Juan A, Martin, Vanesa, Prosper, Felipe, Heiniger, Anabel, Torres, Antonio, Agirre, Xabier

“…Abstract Wnt5a is a member of the Wnt family of proteins that signals through the non-canonical Wnt/Ca2+ pathway to suppress cyclin D1 expression and…”
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5' CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia by Roman-Gomez, Jose, Castillejo, Juan Antonio, Jimenez, Antonio, Gonzalez, Maria Gracia, Moreno, Fernanda, Rodriguez, Maria del Carmen, Barrios, Manuel, Maldonado, Juan, Torres, Antonio

“…The p21 is a downstream effector of p53/p73 and belongs to the CIP/KIP family of cyclin-dependent kinase inhibitors (CDKIs). It is, therefore, a potential…”
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