Search Results - "Castilla, Joaquín"

Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality by Kumar, Jatish, Eraña, Hasier, López-Martínez, Elena, Claes, Nathalie, Martín, Víctor F., Solís, Diego M., Bals, Sara, Cortajarena, Aitziber L., Castilla, Joaquín, Liz-Marzán, Luis M.

“…Amyloid fibrils, which are closely associated with various neurodegenerative diseases, are the final products in many protein aggregation pathways. The…”
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Presymptomatic Detection of Prions in Blood by Saá, Paula, Castilla, Joaquín, Soto, Claudio

“…Prions are thought to be the proteinaceous infectious agents responsible for transmissible spongiform encephalopathies (TSEs). PrPSc, the main component of the…”
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Ultra-efficient Replication of Infectious Prions by Automated Protein Misfolding Cyclic Amplification by Saá, Paula, Castilla, Joaquín, Soto, Claudio

“…Prions are the unconventional infectious agents responsible for transmissible spongiform encephalopathies, which appear to be composed mainly or exclusively of…”
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Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear by Ferreira, Natalia C., Charco, Jorge M., Plagenz, Jakob, Orru, Christina D., Denkers, Nathanial D., Metrick, Michael A., Hughson, Andrew G., Griffin, Karen A., Race, Brent, Hoover, Edward A., Castilla, Joaquín, Nichols, Tracy A., Miller, Michael W., Caughey, Byron

“…Efforts to contain the spread of chronic wasting disease (CWD), a fatal, contagious prion disease of cervids, would be aided by the availability of additional…”
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Glycans are not necessary to maintain the pathobiological features of bovine spongiform encephalopathy by Otero, Alicia, Barrio, Tomás, Eraña, Hasier, Charco, Jorge M, Betancor, Marina, Díaz-Domínguez, Carlos M, Marín, Belén, Andréoletti, Olivier, Torres, Juan M, Kong, Qingzhong, Badiola, Juan J, Bolea, Rosa, Castilla, Joaquín

“…The role of the glycosylation status of PrP C in the conversion to its pathological counterpart and on cross-species transmission of prion strains has been…”
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Cell-free propagation of prion strains by Castilla, Joaquín, Morales, Rodrigo, Saá, Paula, Barria, Marcelo, Gambetti, Pierluigi, Soto, Claudio

“…Prions are the infectious agents responsible for prion diseases, which appear to be composed exclusively by the misfolded prion protein (PrP Sc ). Disease is…”
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Detection of prions in blood by Soto, Claudio, Castilla, Joaquín, Saá, Paula

“…Prion diseases are caused by an unconventional infectious agent termed prion, composed mainly of the misfolded prion protein (PrPSc). The development of highly…”
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Prion-like disorders and Transmissible Spongiform Encephalopathies: An overview of the mechanistic features that are shared by the various disease-related misfolded proteins by Eraña, Hasier, Venegas, Vanesa, Moreno, Jorge, Castilla, Joaquín

“…Prion diseases or Transmissible Spongiform Encephalopathies (TSEs) are a group of fatal neurodegenerative disorders affecting several mammalian species. Its…”
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Prion Strain Mutation Determined by Prion Protein Conformational Compatibility and Primary Structure by Angers, Rachel C, Kang, Hae-Eun, Napier, Dana, Browning, Shawn, Seward, Tanya, Mathiason, Candace, Balachandran, Aru, McKenzie, Debbie, Castilla, Joaquín, Soto, Claudio, Jewell, Jean, Graham, Catherine, Hoover, Edward A, Telling, Glenn C

“…Prions are infectious proteins composed of the abnormal disease-causing isoform PrPSc, which induces conformational conversion of the host-encoded normal…”
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In Vitro Generation of Infectious Scrapie Prions by Castilla, Joaquín, Saá, Paula, Hetz, Claudio, Soto, Claudio

“…Prions are unconventional infectious agents responsible for transmissible spongiform encephalopathy (TSE) diseases. They are thought to be composed exclusively…”
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Biosemiotics comprehension of PrP code and prion disease by Coca, Juan R., Eraña, Hasier, Castilla, Joaquín

“…Prions or PrPSc (prion protein, Scrapie isoform) are proteins with an aberrant three-dimensional conformation that present the ability to alter the…”
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Crossing the Species Barrier by PrPSc Replication In Vitro Generates Unique Infectious Prions by Castilla, Joaquín, Gonzalez-Romero, Dennisse, Saá, Paula, Morales, Rodrigo, De Castro, Jorge, Soto, Claudio

“…Prions are unconventional infectious agents composed exclusively of misfolded prion protein (PrPSc), which transmits the disease by propagating its abnormal…”
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A molecular switch controls interspecies prion disease transmission in mice by Sigurdson, Christina J, Nilsson, K Peter R, Hornemann, Simone, Manco, Giuseppe, Fernández-Borges, Natalia, Schwarz, Petra, Castilla, Joaquín, Wüthrich, Kurt, Aguzzi, Adriano

“…Transmissible spongiform encephalopathies are lethal neurodegenerative disorders that present with aggregated forms of the cellular prion protein (PrPC), which…”
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A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions by Eraña, Hasier, Sampedro-Torres-Quevedo, Cristina, Charco, Jorge M., Díaz-Domínguez, Carlos M., Peccati, Francesca, San-Juan-Ansoleaga, Maitena, Vidal, Enric, Gonçalves-Anjo, Nuno, Pérez-Castro, Miguel A., González-Miranda, Ezequiel, Piñeiro, Patricia, Fernández-Veiga, Leire, Galarza-Ahumada, Josu, Fernández-Muñoz, Eva, Perez de Nanclares, Guiomar, Telling, Glenn, Geijo, Mariví, Jiménez-Osés, Gonzalo, Castilla, Joaquín

“…Prion diseases are a group of rapidly progressing neurodegenerative disorders caused by the misfolding of the endogenous prion protein (PrP C ) into a…”
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Prion-Associated Neurodegeneration Causes Both Endoplasmic Reticulum Stress and Proteasome Impairment in a Murine Model of Spontaneous Disease by Otero, Alicia, Betancor, Marina, Eraña, Hasier, Fernández Borges, Natalia, Lucas, José J, Badiola, Juan José, Castilla, Joaquín, Bolea, Rosa

“…Prion diseases are a group of neurodegenerative disorders that can be spontaneous, familial or acquired by infection. The conversion of the prion protein PrP…”
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Cofactors influence the biological properties of infectious recombinant prions by Fernández-Borges, Natalia, Di Bari, Michele A., Eraña, Hasier, Sánchez-Martín, Manuel, Pirisinu, Laura, Parra, Beatriz, Elezgarai, Saioa R., Vanni, Ilaria, López-Moreno, Rafael, Vaccari, Gabriele, Venegas, Vanessa, Charco, Jorge M., Gil, David, Harrathi, Chafik, D’Agostino, Claudia, Agrimi, Umberto, Mayoral, Tomás, Requena, Jesús R., Nonno, Romolo, Castilla, Joaquín

“…Prion diseases are caused by a misfolding of the cellular prion protein (PrP) to a pathogenic isoform named PrP Sc . Prions exist as strains, which are…”
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Unraveling the key to the resistance of canids to prion diseases by Fernández-Borges, Natalia, Parra, Beatriz, Vidal, Enric, Eraña, Hasier, Sánchez-Martín, Manuel A, de Castro, Jorge, Elezgarai, Saioa R, Pumarola, Martí, Mayoral, Tomás, Castilla, Joaquín

“…One of the characteristics of prions is their ability to infect some species but not others and prion resistant species have been of special interest because…”
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Chronic wasting disease in bank voles: characterisation of the shortest incubation time model for prion diseases by Di Bari, Michele Angelo, Nonno, Romolo, Castilla, Joaquín, D'Agostino, Claudia, Pirisinu, Laura, Riccardi, Geraldina, Conte, Michela, Richt, Juergen, Kunkle, Robert, Langeveld, Jan, Vaccari, Gabriele, Agrimi, Umberto

“…In order to assess the susceptibility of bank voles to chronic wasting disease (CWD), we inoculated voles carrying isoleucine or methionine at codon 109…”
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Cerebrospinal Fluid and Plasma Small Extracellular Vesicles and miRNAs as Biomarkers for Prion Diseases by López-Pérez, Óscar, Sanz-Rubio, David, Hernaiz, Adelaida, Betancor, Marina, Otero, Alicia, Castilla, Joaquín, Andréoletti, Olivier, Badiola, Juan José, Zaragoza, Pilar, Bolea, Rosa, Toivonen, Janne M., Martín-Burriel, Inmaculada

“…Diagnosis of transmissible spongiform encephalopathies (TSEs), or prion diseases, is based on the detection of proteinase K (PK)-resistant PrPSc in post-mortem…”
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Prion replication without host adaptation during interspecies transmissions by Bian, Jifeng, Khaychuk, Vadim, Angers, Rachel C., Fernández-Borges, Natalia, Vidal, Enric, Meyerett-Reid, Crystal, Kim, Sehun, Calvi, Carla L., Bartz, Jason C., Hoover, Edward A., Agrimi, Umberto, Richt, Jürgen A., Castilla, Joaquín, Telling, Glenn C.

“…Adaptation of prions to new species is thought to reflect the capacity of the host-encoded cellular form of the prion protein (PrPC) to selectively propagate…”
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