A Method of Dynamic Analysis of Iodine-123-Metaiodobenzylguanidine Scintigrams in Cardiac Mechanical Overload Hypertrophy and Failure

Cardiac sympathetic neuronal degeneration accompanies mechanical overload heart failure. We hypothesized that sympathetic nerve and myocyte failure share a common etiology and that 123I-metaiodobenzylguanidine (MIBG) might provide a precise method of detecting failure in chronic mechanical overload....

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Bibliographic Details
Published in:	The Journal of nuclear medicine (1978) Vol. 34; no. 4; pp. 589 - 600
Main Authors:	Rabinovitch, Mark A, Rose, Colin P, Schwab, Andreas J, Fitchett, David H, Honos, George N, Stewart, James A, Chen, Luis F, Castilla, Elia P, Gomez, Alvaro A, Abrahamowicz, Michal
Format:	Journal Article
Language:	English
Published:	United States Soc Nuclear Med 01-04-1993
Subjects:	3-Iodobenzylguanidine Clonidine - therapeutic use Female Heart - diagnostic imaging Heart - innervation Heart Failure - diagnostic imaging Heart Transplantation - diagnostic imaging Humans Hypertrophy, Left Ventricular - diagnostic imaging Image Processing, Computer-Assisted Iodine Radioisotopes Iodobenzenes Male Middle Aged Premedication Radionuclide Imaging Reproducibility of Results Sympatholytics
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Summary:	Cardiac sympathetic neuronal degeneration accompanies mechanical overload heart failure. We hypothesized that sympathetic nerve and myocyte failure share a common etiology and that 123I-metaiodobenzylguanidine (MIBG) might provide a precise method of detecting failure in chronic mechanical overload. Our aim was to develop a method for the dynamic analysis of 123I-MIBG scintigrams which could yield a quantitative index of myocardial sympathetic neuronal function in this condition. We performed serial 123I-MIBG scintigraphy in 33 volunteers, 10 orthotopic cardiac transplant recipients and 26 patients with chronic mechanical overload of the left ventricle. We constructed a compartmental model in which total heart activity represents the sum of cardiac sympathetic vesicular and cytosolic pools. Patients with antecedent mechanical overload heart failure or myocardial dysfunction had accelerated myocardial egress of tracer that we ascribed to a specific impairment in vesicular storage rather than to a more rapid turnover of an intact vesicular pool.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0161-5505 1535-5667