Search Results - "Castilho, Róger Frigério"

The Contribution of Nicotinamide Nucleotide Transhydrogenase to Peroxide Detoxification Is Dependent on the Respiratory State and Counterbalanced by Other Sources of NADPH in Liver Mitochondria by Ronchi, Juliana Aparecida, Francisco, Annelise, Passos, Luiz Augusto Correa, Figueira, Tiago Rezende, Castilho, Roger Frigério

“…The forward reaction of nicotinamide nucleotide transhydrogenase (NNT) reduces NADP+ at the expense of NADH oxidation and H+ movement down the electrochemical…”
Get full text

2‐Methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria by Amaral, Alexandre Umpierrez, Cecatto, Cristiane, Castilho, Roger Frigério, Wajner, Moacir

“…Accumulation of 2‐methylcitric acid (2MCA) is observed in methylmalonic and propionic acidemias, which are clinically characterized by severe neurological…”
Get full text

IGFBP7 Fuels the Glycolytic Metabolism in B-Cell Precursor Acute Lymphoblastic Leukemia by Sustaining Activation of the IGF1R-Akt-GLUT1 Axis by Artico, Leonardo Luís, Ruas, Juliana Silveira, Teixeira Júnior, José Ricardo, Migita, Natacha Azussa, Seguchi, Gustavo, Shi, Xinghua, Brandalise, Silvia Regina, Castilho, Roger Frigério, Yunes, José Andrés

“…Increased glycolytic metabolism plays an important role in B-cell precursor Acute Lymphoblastic Leukemia (BCP-ALL). We previously showed that IGFBP7 exerts…”
Get full text

Sickle-cell Anemia and Latent Diastolic Dysfunction: Echocardiographic Alterations by Fattori, André, Oliveira, Daniela Camargo, Castilho, Roger Frigério, Coelho, Otávio Rizzi

Get full text

N-Acetylglutamate and N-acetylmethionine compromise mitochondrial bioenergetics homeostasis and glutamate oxidation in brain of developing rats: Potential implications for the pathogenesis of ACY1 deficiency by Bortoluzzi, Vanessa Trindade, Ribeiro, Rafael Teixeira, Pinheiro, Camila Vieira, Castro, Ediandra Tissot, Tavares, Tailine Quevedo, Leipnitz, Guilhian, Sass, Jörn Oliver, Castilho, Roger Frigério, Amaral, Alexandre Umpierrez, Wajner, Moacir

“…Aminoacylase 1 (ACY1) deficiency is an inherited metabolic disorder biochemically characterized by high urinary concentrations of aliphatic N-acetylated amino…”
Get full text

Disruption of mitochondrial bioenergetics, calcium retention capacity and cell viability caused by D-2-hydroxyglutaric acid in the heart by Ribeiro, Rafael Teixeira, Roginski, Ana Cristina, Marschner, Rafael Aguiar, Wajner, Simone Magagnin, Castilho, Roger Frigério, Amaral, Alexandre Umpierrez, Wajner, Moacir

“…Accumulation of D-2-hydroxyglutaric acid (D-2-HG) is the biochemical hallmark of D-2-hydroxyglutaric aciduria type I and, particularly, of D-2-hydroxyglutaric…”
Get full text

Disturbance of bioenergetics and calcium homeostasis provoked by metabolites accumulating in propionic acidemia in heart mitochondria of developing rats by Roginski, Ana Cristina, Wajner, Alessandro, Cecatto, Cristiane, Wajner, Simone Magagnin, Castilho, Roger Frigério, Wajner, Moacir, Amaral, Alexandre Umpierrez

“…Propionic acidemia is caused by lack of propionyl-CoA carboxylase activity. It is biochemically characterized by accumulation of propionic (PA) and…”
Get full text

Disturbance of mitochondrial functions caused by N-acetylglutamate and N-acetylmethionine in brain of adolescent rats: Potential relevance in aminoacylase 1 deficiency by Bortoluzzi, Vanessa Trindade, Ribeiro, Rafael Teixeira, Zemniaçak, Ângela Beatris, Cunha, Sâmela de Azevedo, Sass, Jörn Oliver, Castilho, Roger Frigério, Amaral, Alexandre Umpierrez, Wajner, Moacir

“…Aminoacylase 1 (ACY1) deficiency is a rare genetic disorder that affects the breakdown of short-chain aliphatic N-acetylated amino acids, leading to the…”
Get full text

Disturbance of mitochondrial functions associated with permeability transition pore opening induced by cis-5-tetradecenoic and myristic acids in liver of adolescent rats by Cecatto, Cristiane, Amaral, Alexandre Umpierrez, Wajner, Alessandro, Wajner, Simone Magagnin, Castilho, Roger Frigério, Wajner, Moacir

“…•Cis-5-tetradecenoic (Cis-5) and myristic (Myr) acids accumulate in VLCAD deficiency.•Cis-5 and Myr impair respiration in liver mitochondria and permeabilized…”
Get full text

Experimental evidence that maleic acid markedly compromises glutamate oxidation through inhibition of glutamate dehydrogenase and α-ketoglutarate dehydrogenase activities in kidney of developing rats by Roginski, Ana Cristina, Cecatto, Cristiane, Wajner, Simone Magagnin, Camera, Fernanda Dal’Maso, Castilho, Roger Frigério, Wajner, Moacir, Amaral, Alexandre Umpierrez

“…Maleic acid (MA), which has been reported to be highly excreted in propionic acidemia (PAcidemia), was demonstrated to cause nephropathy by bioenergetics…”
Get full text

Uncoupling, metabolic inhibition and induction of mitochondrial permeability transition in rat liver mitochondria caused by the major long-chain hydroxyl monocarboxylic fatty acids accumulating in LCHAD deficiency by Hickmann, Fernanda Hermes, Cecatto, Cristiane, Kleemann, Daniele, Monteiro, Wagner Oliveira, Castilho, Roger Frigério, Amaral, Alexandre Umpierrez, Wajner, Moacir

“…Patients with long-chain 3-hydroxy-acyl-CoA dehydrogenase (LCHAD) deficiency commonly present liver dysfunction whose pathogenesis is unknown. We studied the…”
Get full text

Metabolite accumulation in VLCAD deficiency markedly disrupts mitochondrial bioenergetics and Ca2+ homeostasis in the heart by Cecatto, Cristiane, Amaral, Alexandre Umpierrez, Silva, Janaína Camacho, Wajner, Alessandro, Schimit, Mariana de Oliveira Vargas, Silva, Lucas Henrique Rodrigues, Wajner, Simone Magagnin, Zanatta, Ângela, Castilho, Roger Frigério, Wajner, Moacir

“…We studied the effects of the major long‐chain fatty acids accumulating in very long‐chain acyl‐CoA dehydrogenase (VLCAD) deficiency, namely…”
Get full text

Toxic effects of phytol and retinol on human glioblastoma cells are associated with modulation of cholesterol and fatty acid biosynthetic pathways by Facchini, Gustavo, Ignarro, Raffaela Silvestre, Rodrigues-Silva, Erika, Vieira, André Schwambach, Lopes-Cendes, Iscia, Castilho, Roger Frigério, Rogerio, Fabio

“…Glioblastoma (GBM) is the most common primary brain tumor. Genetic mutations may reprogram the metabolism of neoplastic cells. Particularly, alterations in…”
Get full text

Sulfasalazine intensifies temozolomide cytotoxicity in human glioblastoma cells by Ignarro, Raffaela Silvestre, Facchini, Gustavo, Vieira, André Schwambach, De Melo, Daniela Rodrigues, Lopes-Cendes, Iscia, Castilho, Roger Frigério, Rogerio, Fabio

“…Temozolomide (TMZ) is an alkylating agent used to treat glioblastoma. This tumor type synthesizes the antioxidant glutathione through system X c − , which is…”
Get full text

Characteristics of sulfasalazine-induced cytotoxicity in C6 rat glioma cells by Ignarro, Raffaela Silvestre, Facchini, Gustavo, de Melo, Daniela Rodrigues, Pelizzaro-Rocha, Karin Juliane, Ferreira, Carmen Veríssima, Castilho, Roger Frigério, Rogerio, Fabio

“…Glioblastoma is the most aggressive primary brain tumor. Surgical resection, radiotherapy and temozolomide (TMZ), an alkylating agent, is the standard of care…”
Get full text

Ethylmalonic Acid Induces Permeability Transition in Isolated Brain Mitochondria by Cecatto, Cristiane, Amaral, Alexandre Umpierrez, Leipnitz, Guilhian, Castilho, Roger Frigério, Wajner, Moacir

“…Predominant accumulation of ethylmalonic acid (EMA) in tissues and biological fluids is a characteristic of patients affected by short chain acyl-CoA…”
Get full text

pCramoll and rCramoll lectins induce cell death in human prostate adenocarcinoma (PC-3) cells by impairment of mitochondrial homeostasis by de Oliveira Figueirôa, Evellyne, Aranda-Souza, Mary Ângela, Varejão, Nathalia, Rossato, Franco Aparecido, Costa, Rute Alves Pereira, Figueira, Tiago Rezende, da Silva, Luís Cláudio Nascimento, Castilho, Roger Frigério, Vercesi, Aníbal Eugênio, dos Santos Correia, Maria Tereza

“…Lectins from Cratylia mollis seed have shown potential in vivo antitumor actions, however the mechanism have not yet been addressed. Here we evaluated the…”
Get full text

Mitochondrial NAD(P) + Transhydrogenase: From Molecular Features to Physiology and Disease by Francisco, Annelise, Figueira, Tiago Rezende, Castilho, Roger Frigério

“…Proton-translocating NAD(P) transhydrogenase, also known as nicotinamide nucleotide transhydrogenase (NNT), catalyzes a reversible reaction coupling the…”
Get more information

Ethylmalonic acid impairs brain mitochondrial succinate and malate transport by Amaral, Alexandre Umpierrez, Cecatto, Cristiane, Busanello, Estela Natasha Brandt, Ribeiro, César Augusto João, Melo, Daniela Rodrigues, Leipnitz, Guilhian, Castilho, Roger Frigério, Wajner, Moacir

“…Tissue accumulation and high urinary excretion of ethylmalonic acid (EMA) occur in ethylmalonic encephalopathy (EE) and short chain acyl-CoA dehydrogenase…”
Get full text

Impairment of mitochondrial bioenergetics and permeability transition induction caused by major long-chain fatty acids accumulating in VLCAD deficiency in skeletal muscle as potential pathomechanisms of myopathy by Cecatto, Cristiane, Amaral, Alexandre Umpierrez, Roginski, Ana Cristina, Castilho, Róger Frigério, Wajner, Moacir

“…cis-5-Tetradecenoic (cis-5) and myristic (Myr) acids predominantly accumulate in patients affected by very long-chain acyl-CoA dehydrogenase (VLCAD)…”
Get full text