First BNCT treatment of a skin melanoma in Argentina: dosimetric analysis and clinical outcome

First BNCT treatment of a skin melanoma in Argentina: dosimetric analysis and clinical outcome

A Phase I/II protocol for treating cutaneuos melanomas with BNCT was designed in Argentina by the Comisión Nacional de Energı́a Atómica and the medical center Instituto Roffo. The first of a cohort of thirty planned patients was treated on October 9, 2003. This article depicts the protocol-based pro...

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Bibliographic Details
Published in:Applied radiation and isotopes Vol. 61; no. 5; pp. 1101 - 1105
Main Authors: González, S.J, Bonomi, M.R, Santa Cruz, G.A, Blaumann, H.R, Larrieu, O.A.Calzetta, Menéndez, P, Rebagliati, R.Jiménez, Longhino, J, Feld, D.B, Dagrosa, M.A, Argerich, C, Castiglia, S.G, Batistoni, D.A, Liberman, S.J, Roth, B.M.C
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-11-2004
Subjects:
Argentina
BNCT
Boron - blood
Boron - pharmacokinetics
Boron Compounds - pharmacokinetics
Boron Compounds - therapeutic use
Boron Neutron Capture Therapy - methods
Clinical Protocols
Clinical trial
Female
Fructose - analogs & derivatives
Fructose - pharmacokinetics
Fructose - therapeutic use
Humans
Melanoma - metabolism
Melanoma - radiotherapy
Melanoma - secondary
Middle Aged
Radiotherapy Planning, Computer-Assisted
Skin melanomas
Skin Neoplasms - metabolism
Skin Neoplasms - radiotherapy
Skin Neoplasms - secondary
Treatment Outcome
Treatment planning
Argentina
Skin melanomas
Clinical trial
BNCT
Treatment planning
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Summary:A Phase I/II protocol for treating cutaneuos melanomas with BNCT was designed in Argentina by the Comisión Nacional de Energı́a Atómica and the medical center Instituto Roffo. The first of a cohort of thirty planned patients was treated on October 9, 2003. This article depicts the protocol-based procedure and describes the first clinical case, treatment regime and planning, patient irradiation, retrospective dosimetric analysis and clinical outcome. Considering the low acute skin toxicity and the complete response in 21 of the 25 subcutaneous melanoma nodules treated, a second irradiation was performed in a different location of the extremity of the same patient. The corresponding clinical outcome is still under evaluation.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2004.05.060