Search Results - "Castets, Perrine"

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy by Castets, Perrine, Lin, Shuo, Rion, Nathalie, Di Fulvio, Sabrina, Romanino, Klaas, Guridi, Maitea, Frank, Stephan, Tintignac, Lionel A., Sinnreich, Michael, Rüegg, Markus A.

“…Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3…”
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Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice by Ozcelik, Sefika, Fraser, Graham, Castets, Perrine, Schaeffer, Véronique, Skachokova, Zhiva, Breu, Karin, Clavaguera, Florence, Sinnreich, Michael, Kappos, Ludwig, Goedert, Michel, Tolnay, Markus, Winkler, David Theo

“…Altered autophagy contributes to the pathogenesis of Alzheimer's disease and other tauopathies, for which curative treatment options are still lacking. We have…”
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mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 by Castets, Perrine, Rion, Nathalie, Théodore, Marine, Falcetta, Denis, Lin, Shuo, Reischl, Markus, Wild, Franziska, Guérard, Laurent, Eickhorst, Christopher, Brockhoff, Marielle, Guridi, Maitea, Ibebunjo, Chikwendu, Cruz, Joseph, Sinnreich, Michael, Rudolf, Rüdiger, Glass, David J., Rüegg, Markus A.

“…Loss of innervation of skeletal muscle is a determinant event in several muscle diseases. Although several effectors have been identified, the pathways…”
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Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I by Brockhoff, Marielle, Rion, Nathalie, Chojnowska, Kathrin, Wiktorowicz, Tatiana, Eickhorst, Christopher, Erne, Beat, Frank, Stephan, Angelini, Corrado, Furling, Denis, Rüegg, Markus A, Sinnreich, Michael, Castets, Perrine

“…Myotonic dystrophy type I (DM1) is a disabling multisystemic disease that predominantly affects skeletal muscle. It is caused by expanded CTG repeats in the…”
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Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21 by Guridi, Maitea, Tintignac, Lionel A, Lin, Shuo, Kupr, Barbara, Castets, Perrine, Rüegg, Markus A

“…Skeletal muscle is the largest organ, comprising 40% of the total body lean mass, and affects whole-body metabolism in multiple ways. We investigated the…”
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The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player? by Castets, Perrine, Ham, Daniel J, Rüegg, Markus A

“…The neuromuscular junction (NMJ) is the chemical synapse connecting motor neurons and skeletal muscle fibers. NMJs allow all voluntary movements, and ensure…”
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CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I by Falcetta, Denis, Quirim, Sandrine, Cocchiararo, Ilaria, Chabry, Florent, Théodore, Marine, Stiefvater, Adeline, Lin, Shuo, Tintignac, Lionel, Ivanek, Robert, Kinter, Jochen, Rüegg, Markus A, Sinnreich, Michael, Castets, Perrine

“…Myotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that neuromuscular junctions (NMJs)…”
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Satellite cell loss and impaired muscle regeneration in selenoprotein N deficiency by CASTETS, Perrine, BERTRAND, Anne T, ROMERO, Norma B, GUICHENEY, Pascale, ALLAMAND, Valérie, BEUVIN, Maud, FERRY, Arnaud, LE GRAND, Fabien, CASTETS, Marie, CHAZOT, Guillaume, REDERSTORFF, Mathieu, KROL, Alain, LESCURE, Alain

“…Selenoprotein N (SelN) deficiency causes a group of inherited neuromuscular disorders termed SEPN1-related myopathies (SEPN1-RM). Although the function of SelN…”
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Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy by Rederstorff, Mathieu, Castets, Perrine, Arbogast, Sandrine, Lainé, Jeanne, Vassilopoulos, Stéphane, Beuvin, Maud, Dubourg, Odile, Vignaud, Alban, Ferry, Arnaud, Krol, Alain, Allamand, Valérie, Guicheney, Pascale, Ferreiro, Ana, Lescure, Alain

“…Selenium is an essential trace element and selenoprotein N (SelN) was the first selenium-containing protein shown to be directly involved in human inherited…”
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mTORC2 affects the maintenance of the muscle stem cell pool by Rion, Nathalie, Castets, Perrine, Lin, Shuo, Enderle, Leonie, Reinhard, Judith R, Rüegg, Markus A

“…The mammalian target of rapamycin complex 2 (mTORC2), containing the essential protein rictor, regulates cellular metabolism and cytoskeletal organization by…”
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Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy by Bentzinger, C Florian, Lin, Shuo, Romanino, Klaas, Castets, Perrine, Guridi, Maitea, Summermatter, Serge, Handschin, Christoph, Tintignac, Lionel A, Hall, Michael N, Rüegg, Markus A

“…Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master…”
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"Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders by Castets, Perrine, Frank, Stephan, Sinnreich, Michael, Rüegg, Markus A

“…Recent research has revealed that autophagy, a major catabolic process in cells, is dysregulated in several neuromuscular diseases and contributes to the…”
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Back to basics: Optimization of DNA and RNA transfer in muscle cells using recent transfection reagents by Cocchiararo, Ilaria, Cornut, Mélanie, Soldati, Hadrien, Bonavoglia, Alessandro, Castets, Perrine

“…C2C12 cells are widely used in the muscle field, as they differentiate easily into myotubes and show limited constraints to culture as compared to primary…”
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mTOR controls embryonic and adult myogenesis via mTORC1 by Rion, Nathalie, Castets, Perrine, Lin, Shuo, Enderle, Leonie, Reinhard, Judith R, Eickhorst, Christopher, Rüegg, Markus A

“…The formation of multi-nucleated muscle fibers from progenitors requires the fine-tuned and coordinated regulation of proliferation, differentiation and…”
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Selenoprotein N in skeletal muscle: from diseases to function by Castets, Perrine, Lescure, Alain, Guicheney, Pascale, Allamand, Valérie

“…Selenoprotein N (SelN) deficiency causes several inherited neuromuscular disorders collectively termed SEPN1 -related myopathies, characterized by early onset,…”
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Identification of a muscle-specific isoform of VMA21 as a potent actor in X-linked myopathy with excessive autophagy pathogenesis by Cocchiararo, Ilaria, Cattaneo, Olivia, Rajendran, Jayasimman, Chabry, Florent, Cornut, Mélanie, Soldati, Hadrien, Bigot, Anne, Mamchaoui, Kamel, Gibertini, Sara, Bouche, Axelle, Ham, Daniel J, Laumonier, Thomas, Prola, Alexandre, Castets, Perrine

“…Abstract Defective lysosomal acidification is responsible for a large range of multi-systemic disorders associated with impaired autophagy. Diseases caused by…”
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MTORC1 determines autophagy through ULK1 regulation in skeletal muscle by Castets, Perrine, Rüegg, Markus A

“…Autophagy impairment has been implicated in several muscle disorders and in age-related dysfunction. Although previous reports pointed to FOXO as a positive…”
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CaMKII[beta] deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I by Falcetta, Denis, Quirim, Sandrine, Cocchiararo, Ilaria, Chabry, Florent, Théodore, Marine, Stiefvater, Adeline, Lin, Shuo, Tintignac, Lionel, Ivanek, Robert, Kinter, Jochen, Rüegg, Markus A, Sinnreich, Michael, Castets, Perrine

“…Myotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that neuromuscular junctions (NMJs)…”
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Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans by Schoenmakers, Erik, Agostini, Maura, Mitchell, Catherine, Schoenmakers, Nadia, Papp, Laura, Rajanayagam, Odelia, Padidela, Raja, Ceron-Gutierrez, Lourdes, Doffinger, Rainer, Prevosto, Claudia, Luan, Jian'an, Montano, Sergio, Lu, Jun, Castanet, Mireille, Clemons, Nick, Groeneveld, Matthijs, Castets, Perrine, Karbaschi, Mahsa, Aitken, Sri, Dixon, Adrian, Williams, Jane, Campi, Irene, Blount, Margaret, Burton, Hannah, Muntoni, Francesco, O'Donovan, Dominic, Dean, Andrew, Warren, Anne, Brierley, Charlotte, Baguley, David, Guicheney, Pascale, Fitzgerald, Rebecca, Coles, Alasdair, Gaston, Hill, Todd, Pamela, Holmgren, Arne, Khanna, Kum Kum, Cooke, Marcus, Semple, Robert, Halsall, David, Wareham, Nicholas, Schwabe, John, Grasso, Lucia, Beck-Peccoz, Paolo, Ogunko, Arthur, Dattani, Mehul, Gurnell, Mark, Chatterjee, Krishna

“…Selenium, a trace element that is fundamental to human health, is incorporated into some proteins as selenocysteine (Sec), generating a family of…”
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Selenoprotein N is dynamically expressed during mouse development and detected early in muscle precursors by Castets, Perrine, Maugenre, Svetlana, Gartioux, Corine, Rederstorff, Mathieu, Krol, Alain, Lescure, Alain, Tajbakhsh, Shahragim, Allamand, Valérie, Guicheney, Pascale

“…In humans, mutations in the SEPN1 gene, encoding selenoprotein N (SelN), are involved in early onset recessive neuromuscular disorders, referred to as…”
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