Search Results - "Caster, Joseph"

Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical trials by Caster, Joseph M., Patel, Artish N., Zhang, Tian, Wang, Andrew

“…Nanomedicine is a relatively new field that is rapidly evolving. Formulation of drugs on the nanoscale imparts many physical and biological advantages. Such…”
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Clinical Translation of Nanomedicine by Min, Yuanzeng, Caster, Joseph M, Eblan, Michael J, Wang, Andrew Z

“…Clinical applications of nanomedicine and nanotechnology are examined. Topics include liposome and lipid-based nanomedicine, protein nanoparticles and…”
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Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy by Min, Yuanzeng, Roche, Kyle C., Tian, Shaomin, Eblan, Michael J., McKinnon, Karen P., Caster, Joseph M., Chai, Shengjie, Herring, Laura E., Zhang, Longzhen, Zhang, Tian, DeSimone, Joseph M., Tepper, Joel E., Vincent, Benjamin G., Serody, Jonathan S., Wang, Andrew Z.

“…Nanoparticles can be utilized to capture tumour antigens and improve their presentation, which in turn improves the efficacy of cancer immunotherapy…”
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Optimizing Advances in Nanoparticle Delivery for Cancer Immunotherapy by Caster, Joseph M., Callaghan, Cameron, Seyedin, Steven N., Henderson, Kelly, Sun, Bo, Wang, Andrew Z.

“…Cancer immunotherapy is one of the fastest growing and most promising fields in clinical oncology. T-cell checkpoint inhibitors are revolutionizing the…”
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Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic by Au, Kin Man, Satterlee, Andrew, Min, Yuanzeng, Tian, Xi, Kim, Young Seok, Caster, Joseph M, Zhang, Longzhen, Zhang, Tian, Huang, Leaf, Wang, Andrew Z

“…Abstract Zoledronate (Zol) is a third-generation bisphosphonate that is widely used as an anti-resorptive agent for the treatment of cancer bone metastasis…”
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Correction to “Improving Cancer Chemoradiotherapy Treatment by Dual Controlled Release of Wortmannin and Docetaxel in Polymeric Nanoparticles” by Au, Kin Man, Min, Yuanzeng, Tian, Xi, Zhang, Longzhen, Perello, Virginia, Caster, Joseph M., Wang, Andrew Z.

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Improving Cancer Chemoradiotherapy Treatment by Dual Controlled Release of Wortmannin and Docetaxel in Polymeric Nanoparticles by Au, Kin Man, Min, Yuanzeng, Tian, Xi, Zhang, Longzhen, Perello, Virginia, Caster, Joseph M, Wang, Andrew Z

“…Combining molecularly targeted agents and chemotherapeutics is an emerging strategy in cancer treatment. We engineered sub-50 nm diameter diblock copolymer…”
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The Role of Definitive Radiation and Surgery in Metastatic Esophageal Cancer: An NCDB Investigation by Seyedin, Steven N., Parekh, Kalpaj R., Ginader, Timothy, Caster, Joseph M.

“…Approximately 40% of patients with esophageal cancer present with metastatic disease. Survival with palliative treatment is poor, and the benefit of aggressive…”
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Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors by Wang, Edina C, Min, Yuanzeng, Palm, Robert C, Fiordalisi, James J, Wagner, Kyle T, Hyder, Nabeel, Cox, Adrienne D, Caster, Joseph M, Tian, Xi, Wang, Andrew Z

“…Abstract Histone deacetylase inhibitors (HDACIs) represent a class of promising agents that can improve radiotherapy in cancer treatment. However, the full…”
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Nanotechnology and machine learning enable circulating tumor cells as a reliable biomarker for radiotherapy responses of gastrointestinal cancer patients by Poellmann, Michael J., Bu, Jiyoon, Liu, Stanley, Wang, Andrew Z., Seyedin, Steven N., Chandrasekharan, Chandrikha, Hong, Heejoo, Kim, YoungSoo, Caster, Joseph M., Hong, Seungpyo

“…A highly sensitive, circulating tumor cell (CTC)-based liquid biopsy was used to monitor gastrointestinal cancer patients during treatment to determine if CTC…”
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Combination Therapy with Radiation and PARP Inhibition Enhances Responsiveness to Anti-PD-1 Therapy in Colorectal Tumor Models by Seyedin, Steven N., Hasibuzzaman, M.M., Pham, Vivan, Petronek, Michael S., Callaghan, Cameron, Kalen, Amanda L., Mapuskar, Kranti A., Mott, Sarah L., Spitz, Douglas R., Allen, Bryan G., Caster, Joseph M.

“…The majority of colorectal cancers are resistant to cancer immune checkpoint inhibitors. Ionizing radiation (IR) and several radiosensitizers, including PARP…”
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Effect of particle size on the biodistribution, toxicity, and efficacy of drug-loaded polymeric nanoparticles in chemoradiotherapy by Caster, Joseph M, Yu, Stephanie K, Patel, Artish N, Newman, Nicole J, Lee, Zachary J, Warner, Samuel B, Wagner, Kyle T, Roche, Kyle C, Tian, Xi, Min, Yuanzeng, Wang, Andrew Z

“…Abstract Nanoparticle (NP) therapeutics can improve the therapeutic index of chemoradiotherapy (CRT). However, the effect of NP physical properties, such…”
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Risk of Pathologic Upgrading or Locally Advanced Disease in Early Prostate Cancer Patients Based on Biopsy Gleason Score and PSA: A Population-Based Study of Modern Patients by Caster, Joseph M., MD, PhD, Falchook, Aaron D., MD, Hendrix, Laura H., MS, Chen, Ronald C., MD, MPH

“…Purpose Radiation oncologists rely on available clinical information (biopsy Gleason score and prostate-specific antigen [PSA]) to determine the optimal…”
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CRLX101, a Nanoparticle-Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1α by Tian, Xi, Nguyen, Minh, Foote, Henry P, Caster, Joseph M, Roche, Kyle C, Peters, Christian G, Wu, Pauline, Jayaraman, Lata, Garmey, Edward G, Tepper, Joel E, Eliasof, Scott, Wang, Andrew Z

“…Novel agents are needed to improve chemoradiotherapy for locally advanced rectal cancer. In this study, we assessed the ability of CRLX101, an investigational…”
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First-in-Human Phase I Clinical Trial of Pharmacologic Ascorbate Combined with Radiation and Temozolomide for Newly Diagnosed Glioblastoma by Allen, Bryan G, Bodeker, Kellie L, Smith, Mark C, Monga, Varun, Sandhu, Sonia, Hohl, Raymond, Carlisle, Thomas, Brown, Heather, Hollenbeck, Nancy, Vollstedt, Sandy, Greenlee, Jeremy D, Howard, Matthew A, Mapuskar, Kranti A, Seyedin, Steven N, Caster, Joseph M, Jones, Karra A, Cullen, Joseph J, Berg, Daniel, Wagner, Brett A, Buettner, Garry R, TenNapel, Mindi J, Smith, Brian J, Spitz, Douglas R, Buatti, John M

“…Standard treatment for glioblastoma (GBM) includes surgery, radiation therapy (RT), and temozolomide (TMZ), yielding a median overall survival (OS) of…”
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Additive Effects of Cu-ATSM and Radiation on Survival of Diffuse Intrinsic Pontine Glioma Cells by King, Sarah A., Solst, Shane R., Graham, Claire H., Fiore, Lianna Z., Rheem, Rana, Tomanek-Chalkley, Ann, Fath, Melissa A., Caster, Joseph M., Spitz, Douglas R., Howard, Michelle E.

“…Diffuse intrinsic pontine gliomas (DIPG) are highly aggressive and treatment-resistant childhood primary brainstem tumors with a median survival of less than…”
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Clinical experience with adaptive MRI-guided pancreatic SBRT and the use of abdominal compression to reduce treatment volume by Ferris, William S, George, Benjamin, Plichta, Kristin A, Caster, Joseph M, Hyer, Daniel E, Smith, Blake R, St-Aubin, Joel J

“…This work presents a method to treat stereotactic body radiation therapy (SBRT) for pancreatic cancer on a magnetic resonance-guided linear accelerator…”
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Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models by Schramm-Sapyta, Nicole L., Walker, Q. David, Caster, Joseph M., Levin, Edward D., Kuhn, Cynthia M.

“…Background and rationale Epidemiological evidence suggests that people who begin experimenting with drugs of abuse during early adolescence are more likely to…”
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Preclinical evaluation of Promitil®, a radiation-responsive liposomal formulation of mitomycin C prodrug, in chemoradiotherapy by Tian, Xi, Ph.D, Warner, Samuel B, Wagner, Kyle T., B.S, Caster, Joseph M., M.D., Ph.D, Zhang, Tian, M.D, Ohana, Patricia, Ph.D, Gabizon, Alberto A., M.D., Ph.D, Wang, Andrew Z., M.D

“…Abstract Purpose Mitomycin C (MMC) is a potent chemotherapeutic and radiosensitizer, but its use has been limited by toxicity. Promitil is a pegylated…”
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Rapid Peroxide Removal Limits the Radiosensitization of Diffuse Intrinsic Pontine Glioma (DIPG) Cells by Pharmacologic Ascorbate by Solst, Shane R., Mapuskar, Kranti A., Graham, Claire H., King, Sarah A., Rheem, Rana, Current, Kyle, Allen, Bryan G., Caster, Joseph M., Spitz, Douglas R., Howard, Michelle E.

“…Diffuse intrinsic pontine gliomas (DIPG) are an aggressive type of pediatric brain tumor with a very high mortality rate. Surgery has a limited role given the…”
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