Search Results - "Castellino, Robert C."

Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling by Peake, Bridgette F, Eze, Siobhan M, Yang, Lily, Castellino, Robert C, Nahta, Rita

“…Expression of the inflammatory cytokine growth differentiation factor 15 (GDF15) is significantly elevated in many tumor types in association with epithelial…”
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The rationale for targeted therapies in medulloblastoma by MacDonald, Tobey J, Aguilera, Dolly, Castellino, Robert C

“…Medulloblastoma (MB) is the most frequent malignant brain tumor in children. Patients with MB who are classified as having high-risk disease or those with…”
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Ten-eleven translocation protein 1 modulates medulloblastoma progression by Kim, Hyerim, Kang, Yunhee, Li, Yujing, Chen, Li, Lin, Li, Johnson, Nicholas D, Zhu, Dan, Robinson, M Hope, McSwain, Leon, Barwick, Benjamin G, Yuan, Xianrui, Liao, Xinbin, Zhao, Jie, Zhang, Zhiping, Shu, Qiang, Chen, Jianjun, Allen, Emily G, Kenney, Anna M, Castellino, Robert C, Van Meir, Erwin G, Conneely, Karen N, Vertino, Paula M, Jin, Peng, Li, Jian

“…Medulloblastoma (MB) is the most common malignant pediatric brain tumor that originates in the cerebellum and brainstem. Frequent somatic mutations and…”
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Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells by Abouantoun, Thamara J., Castellino, Robert C., MacDonald, Tobey J.

“…We previously showed that inhibition of the platelet-derived growth factor receptor (PDGFR) blocks the survival and migration of medulloblastoma cells…”
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Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma by Castellino, Robert C, Barwick, Benjamin G, Schniederjan, Matthew, Buss, Meghan C, Becher, Oren, Hambardzumyan, Dolores, Macdonald, Tobey J, Brat, Daniel J, Durden, Donald L

“…Recent publications have described an important role for cross talk between PI-3 kinase and sonic hedgehog signaling pathways in the pathogenesis of…”
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Mechanisms of Disease: the PI3K-Akt-PTEN signaling node-an intercept point for the control of angiogenesis in brain tumors by Durden, Donald L, Castellino, Robert C

“…The overall prognosis for patients with high-grade glioma remains dismal, despite advances in treatment modalities including neurosurgery, radiation therapy…”
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Atoh1/MATH1 Adds Up to Ciliogenesis for Transducing SHH Signaling in the Cerebellum by Castellino, Robert C., Kenney, Anna Marie

“…In the developing cerebellum, Sonic hedgehog (SHH) signaling is required for expansion of cerebellar granule neural progenitors, proposed to be cells-of-origin…”
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A Pilot Study Omitting Radiation in the Treatment of Children with Newly Diagnosed Wnt-Activated Medulloblastoma by Cohen, Kenneth J, Munjapara, Vasu, Aguilera, Dolly, Castellino, Robert C, Stapleton, Stacie L, Landi, Daniel, Ashley, David M, Rodriguez, Fausto J, Hawkins, Cynthia, Yang, Edward, London, Wendy, Chi, Susan, Bandopadhayay, Pratiti

“…Treatment of wingless (WNT)-activated medulloblastoma (WNT+MB) with surgery, irradiation (XRT), and chemotherapy results in excellent outcomes. We studied the…”
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Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8 by De Bortoli, Massimiliano, Castellino, Robert C, Lu, Xin-Yan, Deyo, Jeffrey, Sturla, Lisa Marie, Adesina, Adekunle M, Perlaky, Laszlo, Pomeroy, Scott L, Lau, Ching C, Man, Tsz-Kwong, Rao, Pulivarthi H, Kim, John Y H

“…Medulloblastoma is the most common malignant brain tumor of childhood. Improvements in clinical outcome require a better understanding of the genetic…”
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Overexpressed TP73 induces apoptosis in medulloblastoma by Castellino, Robert C, De Bortoli, Massimiliano, Lin, Linda L, Skapura, Darlene G, Rajan, Jessen A, Adesina, Adekunle M, Perlaky, Laszlo, Irwin, Meredith S, Kim, John Y H

“…Medulloblastoma is the most common malignant brain tumor of childhood. Children who relapse usually die of their disease, which reflects resistance to…”
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A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death by STURLA, Lisa-Marie, COWAN, Christopher W, GUENTHER, Lillian, CASTELLINO, Robert C, KIM, John Y. H, POMEROY, Scott L

“…Expression of the neurotrophin-3 receptor, tyrosine kinase C (TrkC), is associated with favorable prognosis in medulloblastoma patients. This may be due to…”
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Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial by Johnson, Theodore S, MacDonald, Tobey J, Pacholczyk, Rafal, Aguilera, Dolly, Al-Basheer, Ahmad, Bajaj, Manish, Bandopadhayay, Pratiti, Berrong, Zuzana, Bouffet, Eric, Castellino, Robert C, Dorris, Kathleen, Eaton, Bree R, Esiashvili, Natia, Fangusaro, Jason R, Foreman, Nicholas, Fridlyand, Diana, Giller, Cole, Heger, Ian M, Huang, Chenbin, Kadom, Nadja, Kennedy, Eugene P, Manoharan, Neevika, Martin, William, McDonough, Colleen, Parker, Rebecca S, Ramaswamy, Vijay, Ring, Eric, Rojiani, Amyn, Sadek, Ramses F, Satpathy, Sarthak, Schniederjan, Matthew, Smith, Amy, Smith, Christopher, Thomas, Beena E, Vaizer, Rachel, Yeo, Kee Kiat, Bhasin, Manoj K, Munn, David H

“…Abstract Background Recurrent brain tumors are the leading cause of cancer death in children. Indoleamine 2,3-dioxygenase (IDO) is a targetable metabolic…”
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Correction: Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling by Peake, Bridgette F., Eze, Siobhan M., Yang, Lily, Castellino, Robert C., Nahta, Rita

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Insulin-like growth factor-1 receptor signaling increases the invasive potential of human epidermal growth factor receptor 2-overexpressing breast cancer cells via Src-focal adhesion kinase and forkhead box protein M1 by Sanabria-Figueroa, Eduardo, Donnelly, Siobhan M, Foy, Kevin C, Buss, Meghan C, Castellino, Robert C, Paplomata, Elisavet, Taliaferro-Smith, Latonia, Kaumaya, Pravin T P, Nahta, Rita

“…Resistance to the human epidermal growth factor receptor (HER2)-targeted antibody trastuzumab is a major clinical concern in the treatment of HER2-positive…”
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Response to bevacizumab, irinotecan, and temozolomide in children with relapsed medulloblastoma: a multi-institutional experience by Aguilera, Dolly, Mazewski, Claire, Fangusaro, Jason, MacDonald, Tobey J., McNall-Knapp, Rene Y., Hayes, Laura L., Kim, Sungjin, Castellino, Robert C.

“…Purpose Chemotherapy for relapsed medulloblastoma has been inadequate, and most patients succumb to disease. Methods We retrospectively reviewed nine cases of…”
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Pediatric metastatic extracranial high-grade glioma: A case report and literature review by Ali, Naba, Eaton, Bree R, Fangusaro, Jason R, Castellino, Robert C, Velázquez Vega, José E, Chern, Joshua J, Schniederjan, Matthew, Patil, Prabhumallikarjun

“…Abstract We report a case of a 10-year-old male with a right frontal diffuse pediatric-type high-grade glioma (HGG), H3-wild-type (WT), and IDH-WT, diagnosed…”
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Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression by Nahta, Rita, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Andrade-Vieira, Rafaela, Bay, Sarah N, Brown, Dustin G, Calaf, Gloria M, Castellino, Robert C, Cohen-Solal, Karine A, Colacci, Annamaria, Cruickshanks, Nichola, Dent, Paul, Di Fiore, Riccardo, Forte, Stefano, Goldberg, Gary S, Hamid, Roslida A, Krishnan, Harini, Laird, Dale W, Lasfar, Ahmed, Marignani, Paola A, Memeo, Lorenzo, Mondello, Chiara, Naus, Christian C, Ponce-Cusi, Richard, Raju, Jayadev, Roy, Debasish, Roy, Rabindra, Ryan, Elizabeth P, Salem, Hosni K, Scovassi, A Ivana, Singh, Neetu, Vaccari, Monica, Vento, Renza, Vondráček, Jan, Wade, Mark, Woodrick, Jordan, Bisson, William H

“…As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators…”
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Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D by Castellino, Robert C., De Bortoli, Massimiliano, Lu, Xiongbin, Moon, Sung-Hwan, Nguyen, Thuy-Ai, Shepard, Mark A., Rao, Pulivarthi H., Donehower, Lawrence A., Kim, John Y. H.

“…Medulloblastoma is the most common malignant brain tumor of childhood. Despite numerous advances, clinical challenges range from recurrent and progressive…”
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Response of subependymal giant cell astrocytoma with spinal cord metastasis to everolimus by Aguilera, Dolly, Flamini, Robert, Mazewski, Claire, Schniederjan, Matthew, Hayes, Laura, Boydston, William, Castellino, Robert C, MacDonald, Tobey J

“…Brain subependymal giant cell astrocytomas (SEGAs) in patients with tuberous sclerosis have been reported to respond to everolimus. A 15-year-old male patient…”
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HDM2 promotes WIP1-mediated medulloblastoma growth by Buss, Meghan C, Read, Tracy-Ann, Schniederjan, Matthew J, Gandhi, Khanjan, Castellino, Robert C

“…Medulloblastoma is the most common malignant childhood brain tumor. The protein phosphatase and oncogene WIP1 is over-expressed or amplified in a significant…”
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