Chromosomal abnormalities are related to location and grade of osteoarthritis

To investigate the frequency of numerical aberrations of chromosomes 7, X and Y in patients with osteoarthritis (OA) by performing fluorescent in situ hybridization (FISH) studies on articular cartilage, and to correlate the chromosomal changes with the degree and location of articular involvement....

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Bibliographic Details
Published in:	Osteoarthritis and cartilage Vol. 12; no. 12; pp. 982 - 985
Main Authors:	Castellanos, Mariana V., Hernández, Jesús M., Ramos, Luis, Belén González, M., Gutiérrez, Norma C., Leone, Paola E., Lumbreras, Eva, Robledo, Cristina, García Hernández, Juan L.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-12-2004
Subjects:	Aged Aged, 80 and over Cartilage Cartilage, Articular Case-Control Studies Chromosome Aberrations Chromosome Deletion Chromosomes, Human, Pair 7 Chromosomes, Human, X Chromosomes, Human, Y Female FISH Humans In Situ Hybridization, Fluorescence Male Middle Aged Osteoarthritis Osteoarthritis - genetics Osteoarthritis - pathology Osteoarthritis, Hip - genetics Osteoarthritis, Hip - pathology Osteoarthritis, Knee - genetics Osteoarthritis, Knee - pathology Trisomy Trisomy 7 FISH Cartilage Osteoarthritis Trisomy 7
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Summary:	To investigate the frequency of numerical aberrations of chromosomes 7, X and Y in patients with osteoarthritis (OA) by performing fluorescent in situ hybridization (FISH) studies on articular cartilage, and to correlate the chromosomal changes with the degree and location of articular involvement. Thirty-four women and 10 men with OA were included in the study. As a control group, 6 women and 5 men operated for orthopedic disorders other than OA were analyzed. FISH studies were performed on hip or knee cartilage, using two-color centromere-specific probes for chromosomes 7 & X for women and 7 & Y for men. FISH analysis revealed that 46% of OA patients had numerical abnormalities of chromosomes 7, X or Y. An extra chromosome 7 (trisomy 7) was present in 35% of patients with chromosomal aberrations. All males with OA lost the Y chromosome while 15% of the women had loss of one chromosome X (monosomy X). Trisomy 7 was associated with hip OA ( p = 0.019) and advanced OA according to the Kellgren and Lawrence classification ( p = 0.05). None of the 11 controls showed abnormalities in the chromosomes analyzed. FISH analysis showed the presence of numerical chromosomal abnormalities in the articular cartilage of patients with OA.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1063-4584 1522-9653
DOI:	10.1016/j.joca.2004.08.011