Search Results - "Castellanos, Karla J."

Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice by Pang, Jingbo, Rhodes, Davina H, Pini, Maria, Akasheh, Rand T, Castellanos, Karla J, Cabay, Robert J, Cooper, Dianne, Perretti, Mauro, Fantuzzi, Giamila

“…Obesity and type 2 diabetes are associated with increased production of Galectin-3 (Gal-3), a protein that modulates inflammation and clearance of glucose…”
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Inflammation, Cognition, and White Matter in Older Adults: An Examination by Race by Boots, Elizabeth A, Castellanos, Karla J, Zhan, Liang, Barnes, Lisa L, Tussing-Humphreys, Lisa, Deoni, Sean C L, Lamar, Melissa

“…Non-Latino Black adults have greater risk for Alzheimer's dementia compared to non-Latino White adults, possibly due to factors disproportionally affecting…”
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Adipose tissue‐specific modulation of galectin expression in lean and obese mice: Evidence for regulatory function by Rhodes, Davina H., Pini, Maria, Castellanos, Karla J., Montero‐Melendez, Trinidad, Cooper, Dianne, Perretti, Mauro, Fantuzzi, Giamila

“…Objective: Galectins (Gal) exert many activities, including regulation of inflammation and adipogenesis. We evaluated modulation of Gal‐1, ‐3, ‐9 and ‐12 in…”
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Role of IL-6 in the resolution of pancreatitis in obese mice by Pini, Maria, Rhodes, Davina H., Castellanos, Karla J., Hall, Andrew R., Cabay, Robert J., Chennuri, Rohini, Grady, Eileen F., Fantuzzi, Giamila

“…IL‐6 contributes to the delayed resolution of inflammation and promotes a tumorgenic microenvironment in the pancreas of obese mice. Obesity increases severity…”
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Obesity and IL-6 interact in modulating the response to endotoxemia in mice by Pini, Maria, Castellanos, Karla J., Rhodes, Davina H., Fantuzzi, Giamila

“…► Obese mice with endotoxemia produce higher IL-6 than lean mice. ► Exacerbated weight loss in endotoxemic obese mice is partially mediated by IL-6. ► Obesity…”
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Inhibition of the nucleotide-binding domain, leucine-rich containing family, pyrin-domain containing 3 inflammasome reduces the severity of experimentally induced acute pancreatitis in obese mice by York, Jason M, Castellanos, Karla J, Cabay, Robert J, Fantuzzi, Giamila

“…Acute pancreatitis (AP), although most often a mild and self-limiting inflammatory disease, worsens to a characteristically necrotic severe acute pancreatitis…”
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Rosiglitazone improves survival and hastens recovery from pancreatic inflammation in obese mice by Pini, Maria, Rhodes, Davina H, Castellanos, Karla J, Cabay, Robert J, Grady, Eileen F, Fantuzzi, Giamila

“…Obesity increases severity of acute pancreatitis (AP) by unclear mechanisms. We investigated the effect of the PPAR-gamma agonist rosiglitazone (RGZ, 0.01% in…”
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S31 Cole Relaxation Frequency: A Parameter for Pancreatic Cancer Detection by Bogdanowicz, Les, Guidetti, Martina, Fidaner, Onur, Gehrke, Daniel S., Grycuk, Alexander, Ceres, Donato, John, Margaret C., Bovalis, Constantine, Kundro, Erik, Raijman, Isaac, Grippo, Paul, Castellanos, Karla J., Patel, Akshar

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Metformin Ameliorates Pancreatic Lesion Formation in Lean and Obese El-Kras Mice by Castellanos, Karla J, Rodriguez, Ashley M, Fantuzzi, Giamila, Grippo, Paul

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Inflammatory markers and tract-based structural connectomics in older adults with a preliminary exploration of associations by race by Boots, Elizabeth A., Zhan, Liang, Castellanos, Karla J., Barnes, Lisa L., Tussing-Humphreys, Lisa, Lamar, Melissa

“…Peripheral inflammation has been implicated in cognitive dysfunction and dementia. While studies outline the relationship between elevated inflammation and…”
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Vitamin D, inflammation, and relations to insulin resistance in premenopausal women with morbid obesity by Nguyen, Van T., Li, Xianjun, Elli, Enrique F., Ayloo, Subhashini M., Castellanos, Karla J., Fantuzzi, Giamila, Freels, Sally, Braunschweig, Carol L.

“…Objective In this study, the associations between vitamin D, insulin sensitivity, and inflammation and their relationships with adipose tissue expression of…”
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Sa1798 Repeated Administration of IL-12 and IL-18 Causes Fatty Replacement of the Pancreas in Mice by Malecki, Elise, Castellanos, Karla J, Cabay, Robert J, Fantuzzi, Giamila

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Decreased Oligodendrocyte Nuclear Diameter in Alzheimer's Disease and Lewy Body Dementia by Gagyi, Eva, Kormos, Bernadett, Castellanos, Karla J., Valyi-Nagy, Klara, Korneff, Dennis, LoPresti, Patrizia, Woltjer, Randy, Valyi-Nagy, Tibor

“…To better understand the pathogenesis of dementia, it is important to understand histopathologic changes in neurodegenerative diseases because they might…”
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ARID1A: guardian of normal pancreatic ducts by Castellanos, Karla J, Grippo, Paul J

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Therapeutic administration of orlistat, rosiglitazone, or the chemokine receptor antagonist RS102895 fails to improve the severity of acute pancreatitis in obese mice by Malecki, Elise A, Castellanos, Karla J, Cabay, Robert J, Fantuzzi, Giamila

“…Currently, there is no therapy for severe acute pancreatitis (AP) except for supportive care. The lipase inhibitor orlistat, the peroxisome…”
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Sa1478 Serum Galectin −1 and Galectin-3 are Increased in Diet-Induced Obesity and Associated With Infiltrate and Necrosis in Experimental Acute Pancreatitis in Mice by Pini, Maria, Malecki, Elise, Rhodes, Davina H, Castellanos, Karla J, Cabay, Robert J, Thompson, Douglas R, Fantuzzi, Giamila

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Increased axonal expression of nectin-1 in multiple sclerosis plaques by Castellanos, Karla J., Gagyi, Eva, Kormos, Bernadett, Valyi-Nagy, Klara, Voros, Andras, Shukla, Deepak, Horvath, Szatmar, Slavin, Konstantin V., Valyi-Nagy, Tibor

“…Nectin-1 is a cell adhesion molecule that plays a role in interneuronal synapse formation, in axonal guidance during development and possibly in neuron-glia…”
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Mo2049 - Metformin Ameliorates Pancreatic Lesion Formation in Lean and Obese El-Kras Mice by Castellanos, Karla J., Rodriguez, Ashley M., Fantuzzi, Giamila, Grippo, Paul

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Su306 DIET, GUT MICROBIOME AND THEIR CONTRIBUTION TO INFLAMMATORY INJURY IN ACUTE PANCREATITIS by Agarwal, Mitali, Castellanos, Karla J., Osmani, Kashif, Layden, Brian, Gaskins, H. Rex, Tussing-Humphreys, Lisa, Grippo, Paul, Boulay, Brian R., Mutlu, Ece, Yazici, Cemal

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Sa1090: THE INFLUENCE OF ACTIVIN ON THE TUMOR MICROENVIRONMNET IN COLON CANCER METASTASIS by Mehrotra, Kunaal, Bauer, Jessica, Zessner-Spitzenberg, Jasmin, Wiley, Mark, Kone, Lyonell B., Qiao, Guilin, Castellanos, Karla J., Church, David, Kerr, Rachel S., Kerr, David, Grippo, Paul, Maker, Ajay, Jung, Barbara

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