Search Results - "Castell, J V"

Bladder cancer recurrence surveillance by urine metabolomics analysis by Loras, A., Trassierra, M., Sanjuan-Herráez, D., Martínez-Bisbal, M. C., Castell, J. V., Quintás, G., Ruiz-Cerdá, J. L.

“…Non Muscle Invasive Bladder Cancer (NMIBC) is among the most frequent malignant cancers worldwide. NMIBC is treated by transurethral resection of the bladder…”
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In vitro evaluation of potential hepatotoxicity induced by drugs by Gómez-Lechón, M J, Lahoz, A, Gombau, L, Castell, J V, Donato, M T

“…The liver is the most important target for toxicity caused by drugs. This vulnerability is a consequence of the functional features of the liver and their role…”
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Coordinated induction of drug transporters and phase I and II metabolism in human liver slices by Olinga, P., Elferink, M.G.L., Draaisma, A.L., Merema, M.T., Castell, J.V., Pérez, G., Groothuis, G.M.M.

“…Although regulation of phase I drug metabolism in human liver is relatively well studied, the regulation of phase II enzymes and of drug transporters is…”
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Human hepatocytes in primary culture: the choice to investigate drug metabolism in man by Gómez-Lechón, M J, Donato, M T, Castell, J V, Jover, R

“…Different types of hepatic tissue, including whole or split livers from organ donors or waste liver from therapeutic liver resections, are used to prepare…”
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Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: A quantitative method for oxidative stress assessment of nanoparticle-treated cells by Aranda, A., Sequedo, L., Tolosa, L., Quintas, G., Burello, E., Castell, J.V., Gombau, L.

“…► Nanomaterials interfere with most in vitro fluorimetric screening tests. ► We explore the usefulness of DCFH-DA test to asses NP-induced oxidative stress. ►…”
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Functional characterization of hepatocytes for cell transplantation: customized cell preparation for each receptor by Bonora-Centelles, A, Donato, M T, Lahoz, A, Pareja, E, Mir, J, Castell, J V, Gómez-Lechón, M J

“…The first indication of hepatocyte transplantation is inborn liver-based metabolic disorders. Among these, urea cycle disorders leading to the impairment to…”
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Sequential hepatogenic transdifferentiation of adipose tissue-derived stem cells: relevance of different extracellular signaling molecules, transcription factors involved, and expression of new key marker genes by Bonora-Centelles, A, Jover, R, Mirabet, V, Lahoz, A, Carbonell, F, Castell, J V, Gómez-Lechón, M J

“…Adipose tissue contains a mesenchymal stem cell (MSC) population known as adipose-derived stem cells (ASCs) capable of differentiating into different cell…”
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Human hepatocytes as a tool for studying toxicity and drug metabolism by Gómez-Lechón, M J, Donato, M T, Castell, J V, Jover, R

“…Drugs are usually biotransformed into new chemical species that may have either toxic or therapeutic effects. Drug metabolism studies are routinely performed…”
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Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells by Rodríguez-Antona, C., Donato, M. T., Boobis, A., Edwards, R. J., Watts, P. S., Castell, J. Vicente, Gómez-Lechón, M.-J.

“…1. Cultured hepatic cells have reduced cytochrome P450 (CYP) activities in comparison with human liver, but the mechanism(s) that underlies this circumstance…”
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Interleukin-6 and the acute phase response by Heinrich, P C, Castell, J V, Andus, T

“…A review is presented…”
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In vitro ADME medium/high-throughput screening in drug preclinical development by Lahoz, A, Gombau, L, Donato, M T, Castell, J V, Gómez-Lechón, M J

“…The study of the ADME features of the huge number of new chemical entities (NCEs) produced mainly by combinatorial chemistry has become a bottleneck in the…”
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Exploring Mass Spectrometry Suitability to Examine Human Liver Graft Metabonomic Profiles by Cortés, M, Pareja, E, Castell, J.V, Moya, A, Mir, J, Lahoz, A

“…Abstract Background Transplant surgeons rely on morphologic aspects of the organ as well as clinical and histologic data to decide whether to use a graft…”
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EU research activities in alternative testing strategies: current status and future perspectives by Vanhaecke, T, Snykers, S, Rogiers, V, Garthoff, B, Castell, J. V, Hengstler, J. G

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Cytokine signaling during myocardial infarction: sequential appearance of IL-1 beta and IL-6 by Guillén, I, Blanes, M, Gómez-Lechón, M J, Castell, J V

“…The purpose of this study was to investigate the significance of the sequential changes in proinflammatory cytokines observed in the plasma of patients early…”
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Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma by Rodríguez-Antona, C, Bort, R, Jover, R, Tindberg, N, Ingelman-Sundberg, M, Gómez-Lechón, M J, Castell, J V

“…Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more than 50% of currently used therapeutic drugs, yet the mechanisms that control CYP3A4 basal…”
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Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake by Castell, J V, Friedrich, G, Kuhn, C S, Poppe, G E

“…The human adult intestinal epithelium has traditionally been described as nonpermeable to proteins. However, indirect evidence suggests that reduced absorption…”
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The immunosuppressant drug FK506 prevents Fas-induced apoptosis in human hepatocytes by Gómez-Lechón, M.J., Serralta, A., Donato, M.T., Jiménez, N., O’Connor, E., Castell, J.V., Mir, J.

“…FK506 is a potent immunosuppressive drug used for the prevention of graft rejection in organ transplantation. Experimental and clinical studies have shown…”
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Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex by Marfil, V, Blazquez, M, Serrano, F, Castell, J V, Bort, R

“…c-Myc transcription factor is a key protein involved in cellular growth, proliferation and metabolism. c-Myc is one of the most frequently activated oncogenes,…”
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Cell lines: a tool for in vitro drug metabolism studies by Donato, M T, Lahoz, A, Castell, J V, Gómez-Lechón, M J

“…Primary cultured hepatocytes are a valuable in vitro model for drug metabolism studies. However, their widespread use is greatly hindered by the scarcity of…”
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Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture by Donato, M T, Castell, J V, Gómez-Lechón, M J

“…The dealkylations of 7-ethoxy- and 7-pentoxyresorufin,p-nitrophenol hydroxylation, and regio- and stereoselective hydroxylation of testosterone were measured…”
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