Search Results - "Castela, Ângela"

Molecular mechanisms associated with diabetic endothelial–erectile dysfunction by Castela, Ângela, Costa, Carla

“…Key Points ED is a prevalent complication of diabetes, affecting up to 75% of all diabetic men, and is responsible for a decreased quality of life for these…”
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Xanthohumol Modulates Inflammation, Oxidative Stress, and Angiogenesis in Type 1 Diabetic Rat Skin Wound Healing by Costa, Raquel, Negrão, Rita, Valente, Inês, Castela, Ângela, Duarte, Delfim, Guardão, Luísa, Magalhães, Paulo J, Rodrigues, José A, Guimarães, João T, Gomes, Pedro, Soares, Raquel

“…Type 1 diabetes mellitus is responsible for metabolic dysfunction, accompanied by chronic inflammation, oxidative stress, and endothelium dysfunction, and is…”
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A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis by Alvelos, Maria Inês, Szymczak, Florian, Castela, Ângela, Marín-Cañas, Sandra, de Souza, Bianca Marmontel, Gkantounas, Ioannis, Colli, Maikel, Fantuzzi, Federica, Cosentino, Cristina, Igoillo-Esteve, Mariana, Marselli, Lorella, Marchetti, Piero, Cnop, Miriam, Eizirik, Décio L.

“…Exposure of human pancreatic beta cells to pro-inflammatory cytokines or metabolic stressors is used to model events related to type 1 and type 2 diabetes,…”
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The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells by Alvelos, Maria Inês, Brüggemann, Mirko, Sutandy, Fx Reymond, Juan-Mateu, Jonàs, Colli, Maikel Luis, Busch, Anke, Lopes, Miguel, Castela, Ângela, Aartsma-Rus, Annemieke, König, Julian, Zarnack, Kathi, Eizirik, Décio L

“…In pancreatic β-cells, the expression of the splicing factor SRSF6 is regulated by GLIS3, a transcription factor encoded by a diabetes susceptibility gene…”
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Human periprostatic white adipose tissue is rich in stromal progenitor cells and a potential source of prostate tumor stroma by Ribeiro, Ricardo, Monteiro, Cátia, Silvestre, Ricardo, Castela, Angela, Coutinho, Helena, Fraga, Avelino, Príncipe, Paulo, Lobato, Carlos, Costa, Carla, Cordeiro-da-Silva, Anabela, Lopes, José Manuel, Lopes, Carlos, Medeiros, Rui

“…A body of growing evidence now implicates white adipose tissue as a relevant source of stromal progenitor cells recruited to the tumor microenvironment to form…”
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Increased Endothelial Apoptotic Cell Density in Human Diabetic Erectile Tissue—Comparison with Clinical Data by Costa, Carla, Soares, Raquel, Castela, Ângela, Adães, Sara, Hastert, Véronique, Vendeira, Pedro, Virag, Ronald

“…Erectile dysfunction (ED) is a common complication of diabetes. Endothelial cell (EC) dysfunction is one of the main mechanisms of diabetic ED. However, loss…”
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Differentially expressed angiogenic genes in diabetic erectile tissue — Results from a microarray screening by Castela, Ângela, Soares, Raquel, Rocha, Fátima, Medeiros, Rui, Ribeiro, Ricardo, Monteiro, Cátia, Gomes, Pedro, Vendeira, Pedro, Virag, Ronald, Costa, Carla

“…Diabetes-induced metabolic derangements promote endothelial malfunction, contributing to erectile dysfunction (ED). However, it remains unclear which…”
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Xanthohumol and 8-prenylnaringenin reduce type 2 diabetes-associated oxidative stress by downregulating galectin-3 by Luís, Carla, Costa, Raquel, Rodrigues, Ilda, Castela, Ângela, Coelho, Pedro, Guerreiro, Susana, Gomes, Joana, Reis, Celso, Soares, Raquel

“…Galectin-3 (Gal3) expression is associated with accumulation of Advanced Glycation End products (AGE), a common feature in diabetes mellitus (DM). The role of…”
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Erectile tissue molecular alterations with aging—differential activation of the p42/44 MAP Kinase pathway by Castela, Ângela, Soares, Raquel, Rocha, Fátima, Vendeira, Pedro, Virag, Ronald, Costa, Carla

“…Erectile dysfunction (ED) is a common problem in aged men; however, the molecular events involved in aging ED remain unclear. To better characterize the…”
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An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells by Colli, Maikel L., Ramos-Rodríguez, Mireia, Nakayasu, Ernesto S., Alvelos, Maria I., Lopes, Miguel, Hill, Jessica L. E., Turatsinze, Jean-Valery, Coomans de Brachène, Alexandra, Russell, Mark A., Raurell-Vila, Helena, Castela, Angela, Juan-Mateu, Jonàs, Webb-Robertson, Bobbie-Jo M., Krogvold, Lars, Dahl-Jorgensen, Knut, Marselli, Lorella, Marchetti, Piero, Richardson, Sarah J., Morgan, Noel G., Metz, Thomas O., Pasquali, Lorenzo, Eizirik, Décio L.

“…Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D…”
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ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation by Szymczak, Florian, Cohen-Fultheim, Roni, Thomaidou, Sofia, de Brachène, Alexandra Coomans, Castela, Angela, Colli, Maikel, Marchetti, Piero, Levanon, Erez, Eizirik, Decio, Zaldumbide, Arnaud

“…Enterovirus infection has long been suspected as a possible trigger for type 1 diabetes. Upon infection, viral double-stranded RNA (dsRNA) is recognized by…”
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Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells by Coomans de Brachène, Alexandra, Castela, Angela, Musuaya, Anyïshai E, Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L

“…Type 1 diabetes (T1D) is an autoimmune disease characterized by the progressive destruction of pancreatic beta cells. Interferon-α (IFNα), an antiviral…”
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Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells by Szymczak, Florian, Alvelos, Maria Inês, Marín-Cañas, Sandra, Castela, Ângela, Demine, Stéphane, Colli, Maikel Luis, Op de Beeck, Anne, Thomaidou, Sofia, Marselli, Lorella, Zaldumbide, Arnaud, Marchetti, Piero, Eizirik, Décio L

“…IFNα is a key regulator of the dialogue between pancreatic β cells and the immune system in early type 1 diabetes (T1D). IFNα up-regulates HLA class I…”
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Molecular mechanisms associated with diabetic endothelial--erectile dysfunction by Castela, Angela, Costa, Carla

“…Erectile dysfunction (ED) is a common complication of diabetes, affecting up to 75% of all diabetic men. Although the aetiology of diabetic ED is…”
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Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes by Coomans de Brachène, Alexandra, Scoubeau, Corentin, Musuaya, Anyïshai E., Costa-Junior, Jose Maria, Castela, Angela, Carpentier, Julie, Faoro, Vitalie, Klass, Malgorzata, Cnop, Miriam, Eizirik, Decio L.

“…Aims/hypothesis Diabetes is characterised by progressive loss of functional pancreatic beta cells. None of the therapeutic agents used to treat diabetes arrest…”
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Interferons are key cytokines acting on pancreatic islets in type 1 diabetes by Coomans de Brachène, Alexandra, Alvelos, Maria Ines, Szymczak, Florian, Zimath, Priscila L., Castela, Angela, Marmontel de Souza, Bianca, Roca Rivada, Arturo, Marín-Cañas, Sandra, Yi, Xiaoyan, Op de Beeck, Anne, Morgan, Noel G., Sonntag, Sebastian, Jawurek, Sayro, Title, Alexandra C., Yesildag, Burcak, Pattou, François, Kerr-Conte, Julie, Montanya, Eduard, Nacher, Montserrat, Marselli, Lorella, Marchetti, Piero, Richardson, Sarah J., Eizirik, Decio L.

“…Aims/hypothesis The proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may contribute to innate and adaptive immune responses during insulitis in type 1…”
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PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction by Colli, Maikel L., Hill, Jessica L.E., Marroquí, Laura, Chaffey, Jessica, Dos Santos, Reinaldo S., Leete, Pia, Coomans de Brachène, Alexandra, Paula, Flavia M.M., Op de Beeck, Anne, Castela, Angela, Marselli, Lorella, Krogvold, Lars, Dahl-Jorgensen, Knut, Marchetti, Piero, Morgan, Noel G., Richardson, Sarah J., Eizirik, Décio L.

“…Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains…”
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25-OR: ADA Presidents' Select Abstract: Preclinical Evaluation of TYK2 Inhibitors in Type 1 Diabetes by SYED, FAROOQ, BALLEW, OLIVIA, LEE, CHIH-CHUN, RANA, JYOTI, CASTELA, ANGELA, WEAVER, STACI A., THOMAIDOU, SOFIA, DEMINE, STÉPHANE, COOMANS DE BRACHÈNE, ALEXANDRA, ALVELOS, MARIA I., CHANG, GARRICK, ORR, KARA, YAMADA, KENTARO, LIU, JING, ZALDUMBIDE, ARNAUD, SCHEUNER, DONALYN, EIZIRIK, DECIO L., EVANS-MOLINA, CARMELLA

“…Interferon-α (IFNα) plays a prominent role in type 1 diabetes (T1D) pathogenesis and mediates its effects through the IFN receptor (IFNAR) and the protein…”
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Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes by Coomans de Brachène, Alexandra, Castela, Angela, Op de Beeck, Anne, Mirmira, Raghavendra G., Marselli, Lorella, Marchetti, Piero, Masse, Craig, Miao, Wenyan, Leit, Silvana, Evans‐Molina, Carmella, Eizirik, Decio L.

“…Aim Type 1 diabetes (T1D) is a chronic autoimmune disease leading to progressive loss of pancreatic beta cells. Interferon (IFN)‐α plays a critical role in the…”
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Vasculogenesis and Diabetic Erectile Dysfunction: How Relevant Is Glycemic Control? by Castela, Angela, Gomes, Pedro, Silvestre, Ricardo, Guardão, Luísa, Leite, Liliana, Chilro, Rui, Rodrigues, Ilda, Vendeira, Pedro, Virag, Ronald, Costa, Carla

“…ABSTRACT Erectile dysfunction (ED) is a complication of diabetes, condition responsible for causing endothelial dysfunction (EDys) and hampering repair…”
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