Search Results - "Castel, Pau"

The duality of human oncoproteins: drivers of cancer and congenital disorders by Castel, Pau, Rauen, Katherine A., McCormick, Frank

“…Human oncoproteins promote transformation of cells into tumours by dysregulating the signalling pathways that are involved in cell growth, proliferation and…”
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RIT1 oncoproteins escape LZTR1-mediated proteolysis by Castel, Pau, Cheng, Alice, Cuevas-Navarro, Antonio, Everman, David B, Papageorge, Alex G, Simanshu, Dhirendra K, Tankka, Alexandra, Galeas, Jacqueline, Urisman, Anatoly, McCormick, Frank

“…RIT1 oncoproteins have emerged as an etiologic factor in Noonan syndrome and cancer. Despite the resemblance of RIT1 to other members of the Ras small…”
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PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D by Toska, Eneda, Osmanbeyoglu, Hatice U., Castel, Pau, Chan, Carmen, Hendrickson, Ronald C., Elkabets, Moshe, Dickler, Maura N., Scaltriti, Maurizio, Leslie, Christina S., Armstrong, Scott A., Baselga, José

“…Activating mutations in PIK3CA, the gene encoding phosphoinositide-(3)-kinase α (PI3Kα), are frequently found in estrogen receptor (ER)–positive breast cancer…”
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The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression by Cuevas-Navarro, Antonio, Van, Richard, Cheng, Alice, Urisman, Anatoly, Castel, Pau, McCormick, Frank

“…The spindle assembly checkpoint (SAC) functions as a sensor of unattached kinetochores that delays mitotic progression into anaphase until proper chromosome…”
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PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer by Bosch, Ana, Li, Zhiqiang, Bergamaschi, Anna, Ellis, Haley, Toska, Eneda, Prat, Aleix, Tao, Jessica J, Spratt, Daniel E, Viola-Villegas, Nerissa T, Castel, Pau, Minuesa, Gerard, Morse, Natasha, Rodón, Jordi, Ibrahim, Yasir, Cortes, Javier, Perez-Garcia, Jose, Galvan, Patricia, Grueso, Judit, Guzman, Marta, Katzenellenbogen, John A, Kharas, Michael, Lewis, Jason S, Dickler, Maura, Serra, Violeta, Rosen, Neal, Chandarlapaty, Sarat, Scaltriti, Maurizio, Baselga, José

“…Activating mutations of PIK3CA are the most frequent genomic alterations in estrogen receptor (ER)-positive breast tumors, and selective phosphatidylinositol…”
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Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility by Angulo-Urarte, Ana, Casado, Pedro, Castillo, Sandra D., Kobialka, Piotr, Kotini, Maria Paraskevi, Figueiredo, Ana M., Castel, Pau, Rajeeve, Vinothini, Milà-Guasch, Maria, Millan, Jaime, Wiesner, Cora, Serra, Helena, Muixi, Laia, Casanovas, Oriol, Viñals, Francesc, Affolter, Markus, Gerhardt, Holger, Huveneers, Stephan, Belting, Heinz-Georg, Cutillas, Pedro R., Graupera, Mariona

“…Angiogenesis is a dynamic process relying on endothelial cell rearrangements within vascular tubes, yet the underlying mechanisms and functional relevance are…”
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Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs by Cuevas-Navarro, Antonio, Rodriguez-Muñoz, Laura, Grego-Bessa, Joaquim, Cheng, Alice, Rauen, Katherine A, Urisman, Anatoly, McCormick, Frank, Jimenez, Gerardo, Castel, Pau

“…RAS GTPases are highly conserved proteins involved in the regulation of mitogenic signaling. We have previously described a novel Cullin 3 RING E3 ubiquitin…”
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Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer by Le, Xiuning, Antony, Rajee, Razavi, Pedram, Treacy, Daniel J, Luo, Flora, Ghandi, Mahmoud, Castel, Pau, Scaltriti, Maurizio, Baselga, Jose, Garraway, Levi A

“…PIK3CA (which encodes the PI3K alpha isoform) is the most frequently mutated oncogene in breast cancer. Small-molecule PI3K inhibitors have shown promise in…”
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PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression by Toska, Eneda, Castel, Pau, Chhangawala, Sagar, Arruabarrena-Aristorena, Amaia, Chan, Carmen, Hristidis, Vasilis C., Cocco, Emiliano, Sallaku, Mirna, Xu, Guotai, Park, Jane, Minuesa, Gerard, Shifman, Sophie G., Socci, Nicholas D., Koche, Richard, Leslie, Christina S., Scaltriti, Maurizio, Baselga, José

“…The PI3K pathway integrates extracellular stimuli to phosphorylate effectors such as AKT and serum-and-glucocorticoid-regulated kinase (SGK1). We have…”
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Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer by Tao, Jessica J, Castel, Pau, Radosevic-Robin, Nina, Elkabets, Moshe, Auricchio, Neil, Aceto, Nicola, Weitsman, Gregory, Barber, Paul, Vojnovic, Borivoj, Ellis, Haley, Morse, Natasha, Viola-Villegas, Nerissa Therese, Bosch, Ana, Juric, Dejan, Hazra, Saswati, Singh, Sharat, Kim, Phillip, Bergamaschi, Anna, Maheswaran, Shyamala, Ng, Tony, Penault-Llorca, Frédérique, Lewis, Jason S, Carey, Lisa A, Perou, Charles M, Baselga, José, Scaltriti, Maurizio

“…Both abundant epidermal growth factor receptor (EGFR or ErbB1) and high activity of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway are common and…”
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Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer by Castel, Pau, Toska, Eneda

“…Estrogen Receptor (ER) and the phosphoinositide 3-kinase (PI3K) pathways participate in regulatory crosstalk in breast cancer. We identified that chromatin…”
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Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation by Chen, Sisi, Vedula, Rahul S, Cuevas-Navarro, Antonio, Lu, Bin, Hogg, Simon J, Wang, Eric, Benbarche, Salima, Knorr, Katherine, Kim, Won Jun, Stanley, Robert F, Cho, Hana, Erickson, Caroline, Singer, Michael, Cui, Dan, Tittley, Steven, Durham, Benjamin H, Pavletich, Tatiana S, Fiala, Elise, Walsh, Michael F, Inoue, Daichi, Monette, Sebastien, Taylor, Justin, Rosen, Neal, McCormick, Frank, Lindsley, R Coleman, Castel, Pau, Abdel-Wahab, Omar

“…Recently, screens for mediators of resistance to FLT3 and ABL kinase inhibitors in leukemia resulted in the discovery of LZTR1 as an adapter of a Cullin-3 RING…”
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The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium by Grego-Bessa, Joaquim, Bloomekatz, Joshua, Castel, Pau, Omelchenko, Tatiana, Baselga, José, Anderson, Kathryn V

“…Epithelial morphogenesis and stability are essential for normal development and organ homeostasis. The mouse neural plate is a cuboidal epithelium that…”
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The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes by Riley, Amanda K., Grant, Michael, Snell, Aidan, Cromwell, Elizabeth, Vichas, Athea, Moorthi, Sitapriya, Rominger, Callie, Modukuri, Shrikar P., Urisman, Anatoly, Castel, Pau, Wan, Lixin, Berger, Alice H.

“…RIT1 is a rare and understudied oncogene in lung cancer. Despite structural similarity to other RAS GTPase proteins such as KRAS, oncogenic RIT1 activity does…”
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Defective protein degradation in genetic disorders by Castel, Pau

“…Understanding the molecular mechanisms that underlie different human pathologies is necessary to develop novel therapeutic strategies. An emerging mechanism of…”
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Abstract NG08: Oncoprotein duality in cancer and developmental syndromes: Lessons learned from RAS GTPases by Castel, Pau

“…Abstract The molecular mechanisms by which oncoproteins transform normal cells remains a fundamental question in cancer biology. Recent DNA sequencing studies…”
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Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors by Soler, Adriana, Figueiredo, Ana M, Castel, Pau, Martin, Laura, Monelli, Erika, Angulo-Urarte, Ana, Milà-Guasch, Maria, Viñals, Francesc, Baselga, Jose, Casanovas, Oriol, Graupera, Mariona

“…Mutations in the PI3K pathway occur in 16% of patients with pancreatic neuroendocrine tumors (PanNETs), which suggests that these tumors are an exciting…”
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KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice by Wong, Jasmine C, Perez-Mancera, Pedro A, Huang, Tannie Q, Kim, Jangkyung, Grego-Bessa, Joaquim, Del Pilar Alzamora, Maria, Kogan, Scott C, Sharir, Amnon, Keefe, Susan H, Morales, Carolina E, Schanze, Denny, Castel, Pau, Hirose, Kentaro, Huang, Guo N, Zenker, Martin, Sheppard, Dean, Klein, Ophir D, Tuveson, David A, Braun, Benjamin S, Shannon, Kevin

“…Somatic KRAS mutations are highly prevalent in many cancers. In addition, a distinct spectrum of germline KRAS mutations causes developmental disorders called…”
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Abstract PR05: The role of the RAS GTPase RIT1 in RASopathies and cancer by Castel, Pau

“…Abstract RAS oncoproteins are drivers of tumor initiation and progression and therapies targeting these directly or their downstream pathways have resulted in…”
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Josep Baselga (1959-2021) by Castel, Pau, Toska, Eneda

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