Search Results - "Casteele, M."

Methyl succinate antagonises biguanide‐induced AMPK‐activation and death of pancreatic β‐cells through restoration of mitochondrial electron transfer by Hinke, S A, Martens, G A, Cai, Y, Finsi, J, Heimberg, H, Pipeleers, D, Casteele, M

“…Background and purpose: Two mechanisms have been proposed to explain the insulin‐sensitising properties of metformin in peripheral tissues: (a) inhibition of…”
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Differentiating neural crest stem cells induce proliferation of cultured rodent islet beta cells by Grouwels, G., Vasylovska, S., Olerud, J., Leuckx, G., Ngamjariyawat, A., Yuchi, Y., Jansson, L., Van de Casteele, M., Kozlova, E. N., Heimberg, H.

“…Aims/hypothesis Efficient stimulation of cycling activity in cultured beta cells would allow the design of new strategies for cell therapy in diabetes. Neural…”
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Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas by Van de Casteele, M, Leuckx, G, Baeyens, L, Cai, Y, Yuchi, Y, Coppens, V, De Groef, S, Eriksson, M, Svensson, C, Ahlgren, U, Ahnfelt-Rønne, J, Madsen, O D, Waisman, A, Dor, Y, Jensen, J N, Heimberg, H

“…We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3) + progenitor cells that can differentiate…”
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Making β(-like)-cells from exocrine pancreas by Staels, W., De Groef, S., Bussche, L., Leuckx, G., Van de Casteele, M., De Leu, N., Baeyens, L., Heremans, Y., Heimberg, H.

“…Creating an abundant source of β(‐like)‐cells has been a major goal in diabetes research for many decades. The concept of cell plasticity has inspired many…”
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Accessory cells for β-cell transplantation by Staels, W., De Groef, S., Heremans, Y., Coppens, V., Van Gassen, N., Leuckx, G., Van de Casteele, M., Van Riet, I., Luttun, A., Heimberg, H., De Leu, N.

“…Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes mellitus with persistent risk of glycaemic alterations and…”
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AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase by KEFAS, B. A, HEIMBERG, H, VAULONT, S, MEISSE, D, HUE, L, PIPELEERS, D, CASTEELE, M

“…Prolonged exposure of beta cells to low glucose concentrations triggers their apoptosis and is known to activate AMP-activated protein kinase (AMPK) in beta…”
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STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage by De Groef, S, Renmans, D, Cai, Y, Leuckx, G, Roels, S, Staels, W, Gradwohl, G, Baeyens, L, Heremans, Y, Martens, G A, De Leu, N, Sojoodi, M, Van de Casteele, M, Heimberg, H

“…Partial pancreatic duct ligation (PDL) of mouse pancreas induces a doubling of the β -cell mass mainly through proliferation of pre-existing and newly formed β…”
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AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase by Kefas, BA, Cai, Y, Ling, Z, Heimberg, H, Hue, L, Pipeleers, D, Van de Casteele, M

“…We have recently shown that conditions known to activate AMP-activated protein kinase (AMPK) in primary beta-cells can trigger their apoptosis. The present…”
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In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats by Van de Casteele, M, Omasta, A, Janssens, S, Roskams, T, Desmet, V, Nevens, F, Fevery, J

“…Background: Portal hypertension in cirrhosis results from enhanced intrahepatic resistance to an augmented inflow. The former is partly due to an imbalance…”
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Oxidative breakdown of octanoic acid is maintained in patients with cirrhosis despite advanced disease by Casteele, M., Luypaerts, A., Geypens, B., Fevery, J., Ghoos, Y., Nevens, F.

“…As an octanoic acid 13CO2 breath test is frequently used to test gastric emptying of solid food, the purpose of the present study was to study whether…”
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Human pancreatic duct cells can produce tumour necrosis factor-α that damages neighbouring beta cells and activates dendritic cells by MOVAHEDI, B, VAN DE CASTEELE, M, CALUWE, N, STANGE, G, BRECKPOT, K, THIELEMANS, K, VREUGDENHIL, G, MATHIEU, C, PIPELEERS, D

“…In the human pancreas, a close topographic relationship exists between duct cells and beta cells. This explains the high proportion of duct cells in isolated…”
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Nutrient sensing in pancreatic beta cells suppresses mitochondrial superoxide generation and its contribution to apoptosis by Martens, G, Cai, Y, Hinke, S, Stangé, G, Van de Casteele, M, Pipeleers, D

“…Excessively high glucose concentrations have been shown to damage tissues through stimulation of mitochondrial superoxide generation. This effect has therefore…”
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Blood antioxidant levels in patients with alcoholic liver disease correlate with the degree of liver impairment and are not specific to alcoholic liver injury itself by Van De Casteele, M., Zaman, Z., Zeegers, M., Servaes, R., Fevery, J., Nevens, F.

“…Background: Enhanced production of reactive oxygen species may play a pathogenic role in alcoholic liver injury. Aims: To investigate whether various…”
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IDF2022-0660 Non-HLA polymorphisms diversely impact progression of preclinical islet autoimmunity in distinct subgroups and stages by Vandewalle, J., Van der Auwera, B., Desouter, A., Keymeulen, B., Gorus, F., Casteele, M. Van de

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Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program by Hoorens, A, Van de Casteele, M, Klöppel, G, Pipeleers, D

“…This study demonstrates that rat islet beta cells constitutively express an apoptotic program which is activated when mRNA or protein synthesis is blocked…”
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β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas by Xu, Xiaobo, D'Hoker, Joke, Stangé, Geert, Bonné, Stefan, De Leu, Nico, Xiao, Xiangwei, Van De Casteele, Mark, Mellitzer, Georg, Ling, Zhidong, Pipeleers, Danny, Bouwens, Luc, Scharfmann, Raphael, Gradwohl, Gerard, Heimberg, Harry

“…Novel strategies in diabetes therapy would obviously benefit from the use of beta (β) cell stem/progenitor cells. However, whether or not adult β cell…”
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The impact of parallel regulatory–health technology assessment scientific advice on clinical development. Assessing the uptake of regulatory and health technology assessment recommendations by Tafuri, Giovanni, Lucas, Inês, Estevão, Steve, Moseley, Jane, d'Andon, Anne, Bruehl, Hannah, Gajraj, Elangovan, Garcia, Sonia, Hedberg, Niklas, Massari, Marco, Molina, Andrea, Obach, Mercè, Osipenko, Leeza, Petavy, Frank, Petschulies, Marco, Pontes, Caridad, Russo, Pierluigi, Schiel, Anja, Van de Casteele, Marc, Zebedin‐Brandl, Eva‐Maria, Rasi, Guido, Vamvakas, Spiros

“…Aims The parallel regulatory–health technology assessment scientific advice (PSA) procedure allows manufacturers to receive simultaneous feedback from both EU…”
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Aspartate carbamoyltransferase from a psychrophilic deep-sea bacterium, Vibrio strain 2693: properties of the enzyme, genetic organization and synthesis in Escherichia coli by Xu, Ying, Zhang, Yuanfu, Liang, Ziyuan, Van de Casteele, Mark, Legrain, Christianne, Glansdorff, Nicolas

“…Microbiologie, Vrije Universiteit Brussel B-1070 Brussels, Belgium Flanders Interuniversity Institute for Biotechnology B-1070 Brussels, Belgium Research…”
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Role of pancreatic beta-cells in the process of beta-cell death by PIPELEERS, Daniel, HOORENS, Anne, MARICHAL-PIPELEERS, Miriam, DE CASTEELE, Mark Van, BOUWENS, Luc, ZHIDONG LING

“…Role of pancreatic beta-cells in the process of beta-cell death. D Pipeleers , A Hoorens , M Marichal-Pipeleers , M Van de Casteele , L Bouwens and Z Ling…”
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Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1 by Heimberg, H, Bouwens, L, Heremans, Y, Van De Casteele, M, Lefebvre, V, Pipeleers, D

“…Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain…”
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