Search Results - "Casteel, Darren E."

Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections by Guo, Dong-chuan, Regalado, Ellen, Casteel, Darren E., Santos-Cortez, Regie L., Gong, Limin, Kim, Jeong Joo, Dyack, Sarah, Horne, S. Gabrielle, Chang, Guijuan, Jondeau, Guillaume, Boileau, Catherine, Coselli, Joseph S., Li, Zhenyu, Leal, Suzanne M., Shendure, Jay, Rieder, Mark J., Bamshad, Michael J., Nickerson, Deborah A., Kim, Choel, Milewicz, Dianna M.

“…Gene mutations that lead to decreased contraction of vascular smooth-muscle cells (SMCs) can cause inherited thoracic aortic aneurysms and dissections. Exome…”
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Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor by Kalyanaraman, Hema, Schwappacher, Raphaela, Joshua, Jisha, Zhuang, Shunhui, Scott, Brian T, Klos, Matthew, Casteel, Darren E, Frangos, John A, Dillmann, Wolfgang, Boss, Gerry R, Pilz, Renate B

“…Thyroid hormone (TH) is essential for vertebrate development and the homeostasis of most adult tissues, including bone. TH stimulates target gene expression…”
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Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog by Schwaerzer, Gerburg K., Kalyanaraman, Hema, Casteel, Darren E., Dalton, Nancy D., Gu, Yusu, Lee, Seunghoe, Zhuang, Shunhui, Wahwah, Nisreen, Schilling, Jan M., Patel, Hemal H., Zhang, Qian, Makino, Ayako, Milewicz, Dianna M., Peterson, Kirk L., Boss, Gerry R., Pilz, Renate B.

“…People heterozygous for an activating mutation in protein kinase G1 ( PRKG1 , p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as young…”
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Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate by Fridman, Alla, Saha, Arindam, Chan, Adriano, Casteel, Darren E, Pilz, Renate B, Boss, Gerry R

“…Cells must increase synthesis of purine nucleotides/deoxynucleotides before or during S-phase. We found that rates of purine synthesis via the de novo and…”
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Correction to: Crystal structure of PKG Iβ holoenzyme reveals a trans‑inhibiting dimer assembly by Kim, Choel, Sharma, Rajesh, Casteel, Darren E

“…After publication of abstract S 2‑06 in supplement [1], it was brought to our attention that the second author's name is spelled incorrectly. Originally the…”
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Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I by Huang, Gilbert Y., Kim, Jeong Joo, Reger, Albert S., Lorenz, Robin, Moon, Eui-Whan, Zhao, Chi, Casteel, Darren E., Bertinetti, Daniela, VanSchouwen, Bryan, Selvaratnam, Rajeevan, Pflugrath, James W., Sankaran, Banumathi, Melacini, Giuseppe, Herberg, Friedrich W., Kim, Choel

“…Cyclic guanosine monophosphate (cGMP) and cyclic AMP (cAMP)-dependent protein kinases (PKG and PKA) are closely related homologs, and the cyclic nucleotide…”
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cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss by Ramdani, Ghania, Schall, Nadine, Kalyanaraman, Hema, Wahwah, Nisreen, Moheize, Sahar, Lee, Jenna J, Sah, Robert L, Pfeifer, Alexander, Casteel, Darren E, Pilz, Renate B

“…NO/cGMP signaling is important for bone remodeling in response to mechanical and hormonal stimuli, but the downstream mediator(s) regulating skeletal…”
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Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation by Kim, Jeong Joo, Lorenz, Robin, Arold, Stefan T., Reger, Albert S., Sankaran, Banumathi, Casteel, Darren E., Herberg, Friedrich W., Kim, Choel

“…Cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is a key regulator of smooth muscle and vascular tone and represents an important drug…”
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An auto-inhibited state of protein kinase G and implications for selective activation by Sharma, Rajesh, Kim, Jeong Joo, Qin, Liying, Henning, Philipp, Akimoto, Madoka, VanSchouwen, Bryan, Kaur, Gundeep, Sankaran, Banumathi, MacKenzie, Kevin R, Melacini, Giuseppe, Casteel, Darren E, Herberg, Friedrich W, Kim, Choel

“…Cyclic GMP-dependent protein kinases (PKGs) are key mediators of the nitric oxide/cyclic guanosine monophosphate (cGMP) signaling pathway that regulates…”
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Regulation of Gene Expression by Cyclic GMP by Pilz, Renate B, Casteel, Darren E

“…ABSTRACT—Cyclic GMP, produced in response to nitric oxide and natriuretic peptides, is a key regulator of vascular smooth muscle cell contractility, growth,…”
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Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication by Osborne, Brent W., Wu, Jian, McFarland, Caitlin J., Nickl, Christian K., Sankaran, Banumathi, Casteel, Darren E., Woods, Virgil L., Kornev, Alexandr P., Taylor, Susan S., Dostmann, Wolfgang R.

“…The cGMP-dependent protein kinase (PKG) serves as an integral component of second messenger signaling in a number of biological contexts including cell…”
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Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts by Rangaswami, Hema, Schwappacher, Raphaela, Marathe, Nisha, Zhuang, Shunhui, Casteel, Darren E, Haas, Bodo, Chen, Yong, Pfeifer, Alexander, Kato, Hisashi, Shattil, Sanford, Boss, Gerry R, Pilz, Renate B

“…Mechanical stimulation is crucial for bone growth and remodeling, and fluid shear stress promotes anabolic responses in osteoblasts through multiple second…”
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Crystal Structure of the cGMP-dependent Protein Kinase II Leucine Zipper and Rab11b Protein Complex Reveals Molecular Details of G-kinase-specific Interactions by Reger, Albert S., Yang, Matthew P., Koide-Yoshida, Shizuyo, Guo, Elaine, Mehta, Shrenik, Yuasa, Keizo, Liu, Alan, Casteel, Darren E., Kim, Choel

“…cGMP-dependent protein kinase (PKG)-interacting proteins (GKIPs) mediate cellular targeting of PKG isoforms by interacting with their leucine zipper (LZ)…”
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Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding by Kim, Jeong Joo, Casteel, Darren E, Huang, Gilbert, Kwon, Taek Hun, Ren, Ronnie Kuo, Zwart, Peter, Headd, Jeffrey J, Brown, Nicholas Gene, Chow, Dar-Chone, Palzkill, Timothy, Kim, Choel

“…Cyclic GMP-dependent protein kinases (PKGs) are central mediators of the NO-cGMP signaling pathway and phosphorylate downstream substrates that are crucial for…”
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Letter by Casteel Regarding Article, “Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of the cGMP-Dependent Protein Kinase” by Casteel, Darren E

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Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3 by Hu, Tingfei, Kalyanaraman, Hema, Pilz, Renate B., Casteel, Darren E.

“…Cardiac contraction is modulated by the phosphorylation state of myosin regulatory light chain 2 (MLC-2v). The level of MLC-2v phosphorylation is dependent on…”
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PKGIα is activated by metal-dependent oxidation in vitro but not in intact cells by Aminzai, Sahar, Hu, Tingfei, Pilz, Renate B., Casteel, Darren E.

“…Type I cGMP-dependent protein kinases (PKGIs) are important components of various signaling pathways and are canonically activated by nitric oxide– and…”
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The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43 by Kalyanaraman, Hema, Zhuang, Shunhui, Pilz, Renate B., Casteel, Darren E.

“…The type I cGMP-dependent protein kinases (PKGs) are key regulators of smooth muscle tone, cardiac hypertrophy, and other physiological processes. The two…”
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Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes by Kalyanaraman, Hema, Schwaerzer, Gerburg, Ramdani, Ghania, Castillo, Francine, Scott, Brian T, Dillmann, Wolfgang, Sah, Robert L, Casteel, Darren E, Pilz, Renate B

“…Bone loss and fractures are underrecognized complications of type 1 diabetes and are primarily due to impaired bone formation by osteoblasts. The mechanisms…”
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A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice by Kalyanaraman, Hema, Ramdani, Ghania, Joshua, Jisha, Schall, Nadine, Boss, Gerry R, Cory, Esther, Sah, Robert L, Casteel, Darren E, Pilz, Renate B

“…ABSTRACT Most US Food and Drug Administration (FDA)‐approved treatments for osteoporosis target osteoclastic bone resorption. Only PTH derivatives improve bone…”
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