Search Results - "Castaño, J P"

Splicing machinery is profoundly altered in systemic lupus erythematosus and antiphospholipid syndrome and directly linked to key clinical features by Lopez-Pedrera, Ch, Patiño-Trives, A.M., Cerdó, T., Ortega-Castro, R., Sanchez-Pareja, I., Ibañez-Costa, A., Muñoz-Barrera, L., Ábalos-Aguilera, M.C., Ruiz-Vilchez, D., Seguí Azpilcueta, P., Espinosa, M., Barbarroja, N., Escudero-Contreras, A., Castaño, J.P., Luque, R.M., Ortega, R., Aguirre, M.A., Perez-Sanchez, C.

“…To characterize the splicing machinery (SM) of leukocytes from primary antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE) and antiphospholipid…”
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Somatotroph Tumor Progression during Pegvisomant Therapy: A Clinical and Molecular Study by Marazuela, M, Paniagua, A. E, Gahete, M. D, Lucas, T, Alvarez-Escolá, C, Manzanares, R, Cameselle-Teijeiro, J, Luque-Ramirez, M, Luque, R. M, Fernandez-Rodriguez, E, Castaño, J. P, Bernabeu, I

“…Duration of previous somatostatin analog therapy, radiotherapy, intra-tumoral growth hormone, and insulin receptor expression are associated with higher risk…”
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Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels by Pedraza-Arévalo, S, Córdoba-Chacón, J, Pozo-Salas, A. I, L.-López, F, de Lecea, L, Gahete, M. D, Castaño, J. P, Luque, R. M

“…Somatostatin (SST) and cortistatin (CORT) are two highly related neuropeptides involved in the regulation of various endocrine secretions. In particular, SST…”
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Novel Expression and Direct Effects of Adiponectin in the Rat Testis by Caminos, J. E, Nogueiras, R, Gaytán, F, Pineda, R, González, C. R, Barreiro, M. L, Castaño, J. P, Malagón, M. M, Pinilla, L, Toppari, J, Diéguez, C, Tena-Sempere, M

“…Adiponectin is an adipocyte hormone, with relevant roles in lipid metabolism and glucose homeostasis, recently involved in the control of different endocrine…”
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Somatotroph Tumor Progression during Pegvisomant Therapy: A Clinical and Molecular Study by Marazuela, M, Paniagua, A. E, Gahete, M. D, Lucas, T, Alvarez-Escolá, C, Manzanares, R, Cameselle-Teijeiro, J, Luque-Ramirez, M, Luque, R. M, Fernandez-Rodriguez, E, Castaño, J. P, Bernabeu, I

“…J Clin Endocrinol Metab, published November 10, 2010, 10.1210/jc.2010-1742…”
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Somatotroph Tumor Progression during Pegvisomant Therapy: A Clinical and Molecular Study by Marazuela, M, Paniagua, A. E, Gahete, M. D, Lucas, T, Alvarez-Escolá, C, Manzanares, R, Cameselle-Teijeiro, J, Luque-Ramirez, M, Luque, R. M, Fernandez-Rodriguez, E, Castaño, J. P, Bernabeu, I

“…J Clin Endocrinol Metab, published November 10, 2010, 10.1210/jc.2010-1742…”
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Cortistatin mimics somatostatin by inducing a dual, dose-dependent stimulatory and inhibitory effect on growth hormone secretion in somatotropes by Luque, R M, Peinado, J R, Gracia-Navarro, F, Broglio, F, Ghigo, E, Kineman, R D, Malagón, M M, Castaño, J P

“…Cortistatin is a recently discovered neuropeptide that is structurally related to somatostatin, the classic inhibitor of growth hormone (GH) release…”
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Translational research in neuroendocrine tumors: pitfalls and opportunities by Capdevila, J, Casanovas, O, Salazar, R, Castellano, D, Segura, A, Fuster, P, Aller, J, García-Carbonero, R, Jimenez-Fonseca, P, Grande, E, Castaño, J P

“…Interest in research on neuroendocrine tumors (NETs) has grown in the past 10 years, coinciding with improvements in our understanding of the molecular…”
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A Cellular and Molecular Basis for the Selective Desmopressin-Induced ACTH Release in Cushing Disease Patients: Key Role of AVPR1b Receptor and Potential Therapeutic Implications by Luque, R. M, Ibáñez-Costa, A, López-Sánchez, L. M, Jiménez-Reina, L, Venegas-Moreno, E, Gálvez, M. A, Villa-Osaba, A, Madrazo-Atutxa, A. M, Japón, M. A, de la Riva, A, Cano, D. A, Benito-López, P, Soto-Moreno, A, Gahete, M. D, Leal-Cerro, A, Castaño, J. P

“…Context: Desmopressin is a synthetic agonist of vasopressin receptors (AVPRs). The desmopressin stimulation test is used in the diagnosis and postsurgery…”
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Direct Pituitary Effects of Kisspeptin: Activation of Gonadotrophs and Somatotrophs and Stimulation of Luteinising Hormone and Growth Hormone Secretion by Gutiérrez-Pascual, E., Martínez-Fuentes, A. J., Pinilla, L., Tena-Sempere, M., Malagón, M. M., Castaño, J. P.

“…Recent, compelling evidence indicates that kisspeptins, the products of KiSS‐1 gene, and their receptor GPR54, represent key elements in the neuroendocrine…”
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Ghrelin Induces Growth Hormone (GH) Secretion via Nitric Oxide (NO)/cGMP Signaling by RODRÍGUEZ-PACHECO, F, LUQUE, R M, GARCÍA-NAVARRO, S, GRACIA-NAVARRO, F, CASTAÑO, J P, MALAGÓN, M.M

“…: Ghrelin, a recently discovered 28‐aa peptide, stimulates GH release through a mechanism involving PLC‐ and cAMP‐related signaling pathways. Recently, nitric…”
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Multiple signaling pathways convey central and peripheral signals to regulate pituitary function: Lessons from human and non-human primate models by Vázquez-Borrego, M.C., Gahete, M.D., Martínez-Fuentes, A.J., Fuentes-Fayos, A.C., Castaño, J.P., Kineman, R.D., Luque, R.M.

“…The anterior pituitary gland is a key organ involved in the control of multiple physiological functions including growth, reproduction, metabolism and stress…”
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Somatostatin Dramatically Stimulates Growth Hormone Release from Primate Somatotrophs Acting at Low Doses Via Somatostatin Receptor 5 and Cyclic AMP by Córdoba-Chacón, J., Gahete, M. D., Culler, M. D., Castaño, J. P., Kineman, R. D., Luque, R. M.

“…Somatostatin and cortistatin have been shown to act directly on pituitary somatotrophs to inhibit growth hormone (GH) release. However, previous results from…”
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Analysis of Rab18 and a New Golgin in the Secretory Pathway by MALAGÓN, M.M, CRUZ, D, VÁZQUEZ-MARTÍNEZ, R, PEINADO, J R, ANOUAR, Y, TONON, M.C, VAUDRY, H, GRACIA-NAVARRO, F, CASTAÑO, J P

“…: Two new amphibian genes have been isolated and characterized from frog melanotropes, and the level of expression of these genes is related to the secretory…”
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Gastrointestinal neuroendocrine tumors (NETs): new diagnostic and therapeutic challenges by Castaño, J. P., Sundin, A., Maecke, H. R., Villabona, C., Vazquez-Albertino, R., Navarro, E., Öberg, K.

“…This paper summarizes the current understanding of the biology of somatostatin receptor (sst), role of immunotherapy in neuroendocrine tumor (NET), new agents…”
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Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat by Castellano, J.M., Navarro, V.M., Fernández-Fernández, R., Castaño, J.P., Malagón, M.M., Aguilar, E., Dieguez, C., Magni, P., Pinilla, L., Tena-Sempere, M.

“…Kisspeptins have recently emerged as essential regulators of gonadotropin secretion and puberty onset. These functions are primarily conducted by stimulation…”
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The new truncated somatostatin receptor variant sst5TMD4 is associated to poor prognosis in breast cancer and increases malignancy in MCF-7 cells by Durán-Prado, M, Gahete, M D, Hergueta-Redondo, M, Martínez-Fuentes, A J, Córdoba-Chacón, J, Palacios, J, Gracia-Navarro, F, Moreno-Bueno, G, Malagón, M M, Luque, R M, Castaño, J P

“…Somatostatin receptors (sst1–5) are present in different types of tumors, where they inhibit key cellular processes such as proliferation and invasion…”
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Growth Hormone (GH)-Releasing Factor Differentially Activates Cyclic Adenosine 3′,5′-Monophosphate- and Inositol Phosphate-Dependent Pathways to Stimulate GH Release in Two Porcine Somatotrope Subpopulations by Ramírez, J. L., Castaño, J. P., Torronteras, R., Martínez-Fuentes, A. J., Frawley, L. S., García-Navarro, S., Gracia-Navarro, F.

“…Abstract Somatotropes comprise two morphologically and functionally distinct subpopulations of low (LD) and high (HD) density cells. We recently reported that…”
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Metabolic Fingerprint of Acromegaly and Its Potential Usefulness in Clinical Practice by Biagetti, Betina, Herance, J.R., Ferrer, Roser, Aulinas, Anna, Palomino-Schätzlein, Martina, Mesa, Jordi, Castaño, J.P., Luque, Raul M., Simó, Rafael

“…Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close…”
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Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer by E, Gómez-Gómez, J M, Jiménez-Vacas, S, Pedraza-Arévalo, F, López-López, V, Herrero-Aguayo, D, Hormaechea-Agulla, J, Valero-Rosa, A, Ibáñez-Costa, J, León-González A, R, Sánchez-Sánchez, T, González-Serrano, M J, Requena-Tapia, J P, Castaño, J, Carrasco-Valiente, M D, Gahete, R M, Luque

“…Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is…”
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