Search Results - "Castañón, Maria J."

Molecular architecture and function of the hemidesmosome by Walko, Gernot, Castañón, Maria J., Wiche, Gerhard

“…Hemidesmosomes are multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane. The mechanical…”
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Molecular architecture and function of the hemidesmosome by Walko, Gernot, Castañón, Maria J, Wiche, Gerhard

“…Hemidesmosomes are multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane. The mechanical…”
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Networking and anchoring through plectin: a key to IF functionality and mechanotransduction by Wiche, Gerhard, Osmanagic-Myers, Selma, Castañón, Maria J

“…Intermediate filaments (IFs) are involved in multiple cellular processes that are essential for the maintenance of cell and tissue integrity as well as…”
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Identifying Plectin Isoform Functions through Animal Models by Castañón, Maria J., Wiche, Gerhard

“…Plectin, a high-molecular-weight cytoskeletal linker protein, binds with high affinity to intermediate filaments of all types and connects them to junctional…”
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Plectin deficiency affects precursor formation and dynamics of vimentin networks by Spurny, Radovan, Gregor, Martin, Castañón, Maria J., Wiche, Gerhard

“…Plectin is a typical cytolinker protein that connects intermediate filaments to the other cytoskeletal filament systems and anchors them at membrane-associated…”
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Oxidation and Nitrosylation of Cysteines Proximal to the Intermediate Filament (IF)-binding Site of Plectin: EFFECTS ON STRUCTURE AND VIMENTIN BINDING AND INVOLVEMENT IN IF COLLAPSE by Spurny, Radovan, Abdoulrahman, Kamaran, Janda, Lubomir, Rünzler, Dominik, Köhler, Gottfried, Castañón, Maria J, Wiche, Gerhard

“…As an intermediate filament (IF)-based cytolinker protein, plectin plays a key role in the maintenance of cellular cytoarchitecture and serves at the same time…”
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Plectin–intermediate filament partnership in skin, skeletal muscle, and peripheral nerve by Castañón, Maria J., Walko, Gernot, Winter, Lilli, Wiche, Gerhard

“…Plectin is a large, 500-kDa, intermediate filament (IF)-associated protein. It acts as a cytoskeletal crosslinker and signaling scaffold, affecting mechanical…”
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Mutation in exon 1a of PLEC, leading to disruption of plectin isoform 1a, causes autosomal-recessive skin-only epidermolysis bullosa simplex by Gostyńska, Katarzyna B, Nijenhuis, Miranda, Lemmink, Henny, Pas, Hendri H, Pasmooij, Anna M G, Lang, Kristin Kernland, Castañón, Maria J, Wiche, Gerhard, Jonkman, Marcel F

“…PLEC, the gene encoding the cytolinker protein plectin, has eight tissue-specific isoforms in humans, arising by alternate splicing of the first exon. To date,…”
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Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna by Walko, Gernot, Vukasinovic, Nevena, Gross, Karin, Fischer, Irmgard, Sibitz, Sabrina, Fuchs, Peter, Reipert, Siegfried, Jungwirth, Ute, Berger, Walter, Salzer, Ulrich, Carugo, Oliviero, Castañón, Maria J, Wiche, Gerhard

“…Autosomal recessive mutations in the cytolinker protein plectin account for the multisystem disorders epidermolysis bullosa simplex (EBS) associated with…”
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Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma by Žugec, Maja, Furlani, Borut, Castañon, Maria J, Rituper, Boštjan, Fischer, Irmgard, Broggi, Giuseppe, Caltabiano, Rosario, Barbagallo, Giuseppe M V, Di Rosa, Michelino, Tibullo, Daniele, Parenti, Rosalba, Vicario, Nunzio, Simčič, Saša, Pozo Devoto, Victorio Martin, Stokin, Gorazd B, Wiche, Gerhard, Jorgačevski, Jernej, Zorec, Robert, Potokar, Maja

“…The expression of aquaporin 4 (AQP4) and intermediate filament (IF) proteins is altered in malignant glioblastoma (GBM), yet the expression of the major…”
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Unusual 5′ Transcript Complexity of Plectin Isoforms: Novel Tissue-Specific Exons Modulate Actin Binding Activity by Fuchs, Peter, Zörer, Michael, Rezniczek, Günther A., Spazierer, Daniel, Oehler, Susanne, Castañón, Maria J., Hauptmann, Rudolf, Wiche, Gerhard

“…Plectin, the most versatile cytolinker identified to date, has essential functions in maintaining the mechanical integrity of skin, skeletal muscle and heart,…”
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Human Plectin: Organization of the Gene, Sequence Analysis, and Chromosome Localization (8q24) by Liu, Chang-Gong, Maercker, Christian, Castañon, Maria J., Hauptmann, Rudolf, Wiche, Gerhard

“…Plectin, a 500-kDa intermediate filament binding protein, has been proposed to provide mechanical strength to cells and tissues by acting as a cross-linking…”
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Targeted Proteolysis of Plectin Isoform 1a Accounts for Hemidesmosome Dysfunction in Mice Mimicking the Dominant Skin Blistering Disease EBS-Ogna: e1002396 by Walko, Gernot, Vukasinovic, Nevena, Gross, Karin, Fischer, Irmgard, Sibitz, Sabrina, Fuchs, Peter, Reipert, Siegfried, Jungwirth, Ute, Berger, Walter, Salzer, Ulrich, Carugo, Oliviero, Castañón, Maria J, Wiche, Gerhard

“…Autosomal recessive mutations in the cytolinker protein plectin account for the multisystem disorders epidermolysis bullosa simplex (EBS) associated with…”
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Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiae by Castañón, M J, Spevak, W, Adolf, G R, Chlebowicz-Sledziewska, E, Sledziewski, A

“…cDNA clones encoding human lysozyme were isolated from a human histiocytic cell line (U-937) and a human placenta cDNA library. The clones, ranging in size…”
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Expression of plectin mutant cDNA in cultured cells indicates a role of COOH-terminal domain in intermediate filament association by WICHE, G, GROMOV, D, DONOVAN, A, CASTANON, M. J, FUCHS, E

“…Plectin is an intermediate filament (IF) binding protein of exceptionally large size. Its molecular structure, revealed by EM and predicted by its sequence,…”
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Oxidation and Nitrosylation of Cysteines Proximal to the Intermediate Filament (IF)-binding Site of Plectin by Spurny, Radovan, Abdoulrahman, Kamaran, Janda, Lubomir, Ruönzler, Dominik, Koöhler, Gottfried, Castañón, Maria J., Wiche, Gerhard

“…As an intermediate filament (IF)-based cytolinker protein, plectin plays a key role in the maintenance of cellular cytoarchitecture and serves at the same time…”
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Plectin Transcript Diversity: Identification and Tissue Distribution of Variants with Distinct First Coding Exons and Rodless Isoforms by Elliott, Candace E., Becker, Bruno, Oehler, Susanne, Castañón, Maria J., Hauptmann, Rudolf, Wiche, Gerhard

“…Plectin is a widely expressed protein that is very large in size and that has all the attributes of a multifunctional crosslinking and organizing element of…”
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Saccharomyces cerevisiae cdc15 mutants arrested at a late stage in anaphase are rescued by Xenopus cDNAs encoding N-ras or a protein with beta-transducin repeats by SPEVAK, W, KEIPER, B. D, STRATOWA, C, CASTAÑON, M. J

“…A correction has been published Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Functional coupling of human adenosine receptors to a ligand-dependent reporter gene system by Castañón, M J, Spevak, W

“…We have stably transfected CHO cells that have integrated in their genome a reporter gene under the control of promoter sequences containing several copies of…”
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Expression of Plectin Mutant cDNA in Cultured Cells Indicates a Role of COOH-Teriminal Domain in Intermediate Filament Association by Wiche, Gerhard, Gromov, Dmitri, Donovan, Adriana, Castañón, Maria J., Fuchs, Elaine

“…Plectin is an intermediate filament (IF) binding protein of exceptionally large size. Its molecular structure, revealed by EM and predicted by its sequence,…”
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