Search Results - "Cassiano Martinho, Ana Clara"
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Optimization of benzenesulfonyl derivatives as anti-Trypanosomatidae agents: Structural design, synthesis, and pharmacological assessment against Trypanosoma cruzi and Leishmania infantum
Published in Bioorganic & medicinal chemistry (01-05-2024)“…[Display omitted] Leishmaniasis and Chagas disease are neglected tropical diseases caused by Trypanosomatidae parasites. Given the numerous limitations…”
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A Novel Compound from the Phenylsulfonylpiperazine Class: Evaluation of In Vitro Activity on Luminal Breast Cancer Cells
Published in Molecules (Basel, Switzerland) (20-09-2024)“…Breast cancer (BC) is the most common cancer in women, and is characterized by its histological and molecular heterogeneity. Luminal BC is an estrogen…”
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Synthesis, Design, and Structure‐Activity Relationship of a Benzenesulfonylpiperazine Series against Trypanosoma cruzi
Published in ChemMedChem (06-10-2022)“…Chagas disease is a neglected tropical disease, endemic in Latin America and caused by the protozoan parasite Trypanosoma cruzi. Available treatments show low…”
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Discovery of Arylpiperazines with Broad-Spectrum Antimicrobial Activity and Favorable Pharmacokinetic Profiles
Published in Chemistry & biodiversity (26-09-2024)“…Microorganisms can induce diseases with significant clinical implications for human health. Multidrug-resistant microorganisms have been on the rise worldwide…”
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Synthesis, design, and optimization of a potent and selective series of pyridylpiperazines as promising antimalarial agents
Published in European journal of medicinal chemistry (05-09-2024)“…An optimization of the pyridylpiperazine series against Plasmodium falciparum has been performed, exploring a structure-activity relationship carried out on…”
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