Search Results - "Cassera, Maria Belen"

Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch in Trypanosoma cruzi epimastigotes by Barisón, María Julia, Rapado, Ludmila Nakamura, Merino, Emilio F., Furusho Pral, Elizabeth Mieko, Mantilla, Brian Suarez, Marchese, Letícia, Nowicki, Cristina, Silber, Ariel Mariano, Cassera, Maria Belen

“…Trypanosoma cruzi, the etiological agent of Chagas disease, is a protozoan parasite with a complex life cycle involving a triatomine insect and mammals…”
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Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum by Zimbres, Flavia M., Valenciano, Ana Lisa, Merino, Emilio F., Florentin, Anat, Holderman, Nicole R., He, Guijuan, Gawarecka, Katarzyna, Skorupinska-Tudek, Karolina, Fernández-Murga, Maria L., Swiezewska, Ewa, Wang, Xiaofeng, Muralidharan, Vasant, Cassera, Maria Belen

“…The cis -polyisoprenoid lipids namely polyprenols, dolichols and their derivatives are linear polymers of several isoprene units. In eukaryotes, polyprenols…”
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Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor by Valenciano, Ana Lisa, Fernández-Murga, Maria L., Merino, Emilio F., Holderman, Nicole R., Butschek, Grant J., Shaffer, Karl J., Tyler, Peter C., Cassera, Maria Belen

“…The shikimate pathway, a metabolic pathway absent in humans, is responsible for the production of chorismate, a branch point metabolite. In the malaria…”
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Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited? by Val, Fernando Fonseca, Sampaio, Vanderson Souza, Cassera, Maria Belén, Andrade, Raquel Tapajós, Tauil, Pedro Luiz, Monteiro, Wuelton Marcelo, Lacerda, Marcus Vinícius Guimarães

“…In the 1950s, the strategy of adding chloroquine to food salt as a prophylaxis against malaria was considered to be a successful tool. However, with the…”
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Purine and pyrimidine pathways as targets in Plasmodium falciparum by Cassera, María Belén, Zhang, Yong, Hazleton, Keith Z, Schramm, Vern L

“…Malaria is a leading cause of morbidity and mortality in the tropics. Chemotherapeutic and vector control strategies have been applied for more than a century…”
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond by Van Voorhis, Wesley C, Adams, John H, Adelfio, Roberto, Ahyong, Vida, Akabas, Myles H, Alano, Pietro, Alday, Aintzane, Alemán Resto, Yesmalie, Alsibaee, Aishah, Alzualde, Ainhoa, Andrews, Katherine T, Avery, Simon V, Avery, Vicky M, Ayong, Lawrence, Baker, Mark, Baker, Stephen, Ben Mamoun, Choukri, Bhatia, Sangeeta, Bickle, Quentin, Bounaadja, Lotfi, Bowling, Tana, Bosch, Jürgen, Boucher, Lauren E, Boyom, Fabrice F, Brea, Jose, Brennan, Marian, Burton, Audrey, Caffrey, Conor R, Camarda, Grazia, Carrasquilla, Manuela, Carter, Dee, Belen Cassera, Maria, Chih-Chien Cheng, Ken, Chindaudomsate, Worathad, Chubb, Anthony, Colon, Beatrice L, Colón-López, Daisy D, Corbett, Yolanda, Crowther, Gregory J, Cowan, Noemi, D'Alessandro, Sarah, Le Dang, Na, Delves, Michael, DeRisi, Joseph L, Du, Alan Y, Duffy, Sandra, Abd El-Salam El-Sayed, Shimaa, Ferdig, Michael T, Fernández Robledo, José A, Fidock, David A, Florent, Isabelle, Fokou, Patrick V T, Galstian, Ani, Gamo, Francisco Javier, Gokool, Suzanne, Gold, Ben, Golub, Todd, Goldgof, Gregory M, Guha, Rajarshi, Guiguemde, W Armand, Gural, Nil, Guy, R Kiplin, Hansen, Michael A E, Hanson, Kirsten K, Hemphill, Andrew, Hooft van Huijsduijnen, Rob, Horii, Takaaki, Horrocks, Paul, Hughes, Tyler B, Huston, Christopher, Igarashi, Ikuo, Ingram-Sieber, Katrin, Itoe, Maurice A, Jadhav, Ajit, Naranuntarat Jensen, Amornrat, Jensen, Laran T, Jiang, Rays H Y, Kaiser, Annette, Keiser, Jennifer, Ketas, Thomas, Kicka, Sebastien, Kim, Sunyoung, Kirk, Kiaran, Kumar, Vidya P, Kyle, Dennis E, Lafuente, Maria Jose, Landfear, Scott, Lee, Nathan, Lee, Sukjun, Lehane, Adele M, Li, Fengwu, Little, David, Liu, Liqiong, Llinás, Manuel, Loza, Maria I, Lubar, Aristea, Lucantoni, Leonardo, Lucet, Isabelle, Maes, Louis, Mancama, Dalu

“…A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in…”
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Antimalarial Natural Products by Kingston, David G I, Cassera, Maria Belen

“…Natural products have made a crucial and unique contribution to human health, and this is especially true in the case of malaria, where the natural products…”
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Natural Products as a Source to Discover Novel Drug Targets in P. falciparum by Butler, Joshua H., Zhou, Bin, Yue, Jian‐Min, Cassera, Maria Belen

“…Malaria is a deadly infectious disease that caused an estimated 216 million cases around the world in 2016 according to the World Health Organization…”
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A role for adenine nucleotides in the sensing mechanism to purine starvation in Leishmania donovani by Martin, Jessica L., Yates, Phillip A., Boitz, Jan M., Koop, Dennis R., Fulwiler, Audrey L., Cassera, Maria Belen, Ullman, Buddy, Carter, Nicola S.

“…Summary Purine salvage by Leishmania is an obligatory nutritional process that impacts both cell viability and growth. Previously, we have demonstrated that…”
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Quantification of nerolidol in mouse plasma using gas chromatography–mass spectrometry by Saito, Alexandre Yukio, Sussmann, Rodrigo Antonio Ceschini, Kimura, Emilia Akemi, Cassera, Maria Belen, Katzin, Alejandro Miguel

“…•We optimized a fast and sensitive GC–MS method for detection and quantification of the sesquiterpene nerolidol.•The method was applied for preliminary…”
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Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure–activity studies by Yao, Zhong-Ke, Krai, Priscilla M., Merino, Emilio F., Simpson, Morgan E., Slebodnick, Carla, Cassera, Maria Belen, Carlier, Paul R.

“…[Display omitted] Compounds that target isoprenoid biosynthesis in Plasmodium falciparum could be a welcome addition to malaria chemotherapy, since the…”
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β‑Carboline-3-carboxamide Antimalarials: Structure–Activity Relationship, ADME-Tox Studies, and Resistance Profiling by Mathew, Jopaul, Zhou, Bo, Haney, Reagan S., Kunz, Kevin A., Do Amaral, Leticia S., Roy Chowdhury, Rudraneel, Butler, Joshua H., Li, Haibo, Chakraborty, Amarraj J., Tabassum, Anika, Bremers, Emily K., Merino, Emilio F., Coyle, Rachael, Lee, Marcus C. S., Baud, Delphine, Brand, Stephen, Totrov, Maxim, Cassera, Maria Belen, Carlier, Paul R.

“…The development of parasite resistance to both artemisinin derivatives and their partner drugs jeopardizes the effectiveness of the artemisinin combination…”
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Biological Studies and Target Engagement of the 2‑C‑Methyl‑d‑Erythritol 4‑Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1R,3S)‑MMV008138 and Analogs by Ghavami, Maryam, Merino, Emilio F, Yao, Zhong-Ke, Elahi, Rubayet, Simpson, Morgan E, Fernández-Murga, Maria L, Butler, Joshua H, Casasanta, Michael A, Krai, Priscilla M, Totrov, Maxim M, Slade, Daniel J, Carlier, Paul R, Cassera, Maria Belen

“…Malaria continues to be one of the deadliest diseases worldwide, and the emergence of drug resistance parasites is a constant threat. Plasmodium parasites…”
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Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum by Dharia, Neekesh V, Sidhu, Amar Bir Singh, Cassera, María Belén, Westenberger, Scott J, Bopp, Selina Er, Eastman, Rich T, Plouffe, David, Batalov, Serge, Park, Daniel J, Volkman, Sarah K, Wirth, Dyann F, Zhou, Yingyao, Fidock, David A, Winzeler, Elizabeth A

“…The identification of genetic changes that confer drug resistance or other phenotypic changes in pathogens can help optimize treatment strategies, support the…”
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