Search Results - "Cassatella, marco A."

Social networking of human neutrophils within the immune system by Scapini, Patrizia, Cassatella, Marco A.

“…It is now widely recognized that neutrophils are highly versatile and sophisticated cells that display de novo synthetic capacity and may greatly extend their…”
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Neutrophil-derived cytokines: facts beyond expression by Tecchio, Cristina, Micheletti, Alessandra, Cassatella, Marco A

“…Polymorphonuclear neutrophils, besides their involvement in primary defense against infections - mainly through phagocytosis, generation of toxic molecules,…”
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Neutrophils in the activation and regulation of innate and adaptive immunity by Mantovani, Alberto, Cassatella, Marco A, Costantini, Claudio, Jaillon, Sébastien

“…Key Points Neutrophils have long been viewed as short-lived effector cells of the innate immune system, with a primary role in resistance against extracellular…”
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Human neutrophils in the saga of cellular heterogeneity: insights and open questions by Scapini, Patrizia, Marini, Olivia, Tecchio, Cristina, Cassatella, Marco A.

“…Summary Recent findings have uncovered novel fascinating aspects of the biology of neutrophils, which ultimately attribute to these cells a broader role in…”
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The defensive alliance between neutrophils and NK cells as a novel arm of innate immunity by Costantini, Claudio, Cassatella, Marco A.

“…Review focuses on the molecular mechanisms regulating the interactions between neutrophils and NK cells in the human and mouse system. The immune system is…”
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Neutrophils: New insights and open questions by Ley, Klaus, Hoffman, Hal M, Kubes, Paul, Cassatella, Marco A, Zychlinsky, Arturo, Hedrick, Catherine C, Catz, Sergio D

“…Neutrophils are the first line of defense against bacteria and fungi and help combat parasites and viruses. They are necessary for mammalian life, and their…”
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On the cytokines produced by human neutrophils in tumors by Tecchio, Cristina, Scapini, Patrizia, Pizzolo, Giovanni, Cassatella, Marco A

“…Abstract Although traditionally viewed as short-lived innate immunity cells, only playing a crucial role in host defense toward infections, neutrophils have…”
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Cytokine production by human neutrophils: Revisiting the “dark side of the moon” by Tamassia, Nicola, Bianchetto‐Aguilera, Francisco, Arruda‐Silva, Fabio, Gardiman, Elisa, Gasperini, Sara, Calzetti, Federica, Cassatella, Marco A.

“…Polymorphonuclear neutrophils are the most numerous leucocytes present in human blood, and function as crucial players in innate immune responses. Neutrophils…”
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Evidence for a cross-talk between human neutrophils and Th17 cells by Pelletier, Martin, Maggi, Laura, Micheletti, Alessandra, Lazzeri, Elena, Tamassia, Nicola, Costantini, Claudio, Cosmi, Lorenzo, Lunardi, Claudio, Annunziato, Francesco, Romagnani, Sergio, Cassatella, Marco A.

“…Interleukin-17A (IL-17A) and IL-17F are 2 of several cytokines produced by T helper 17 cells (Th17), which are able to indirectly induce the recruitment of…”
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Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals by Bazzoni, Flavia, Rossato, Marzia, Fabbri, Marco, Gaudiosi, Daniele, Mirolo, Massimiliano, Mori, Laura, Tamassia, Nicola, Mantovani, Alberto, Cassatella, Marco A, Locati, Massimo

“…Inflammation involves a coordinated, sequential, and self limiting sequence of events controlled by positive and negative regulatory mechanisms. Recent studies…”
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IL-10—induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes by Rossato, Marzia, Curtale, Graziella, Tamassia, Nicola, Castellucci, Monica, Mori, Laura, Gasperini, Sara, Mariotti, Barbara, De Luca, Mariacristina, Mirolo, Massimiliano, Cassatella, Marco A., Locati, Massimo, Bazzoni, Flavia

“…IL-10 is a potent anti-inflammatory molecule that, in phagocytes, negatively targets cytokine expression at transcriptional and posttranscriptional levels…”
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The importance of being “pure” neutrophils by Calzetti, Federica, BS, Tamassia, Nicola, PhD, Arruda-Silva, Fabio, MS, Gasperini, Sara, PhD, Cassatella, Marco A., MD, PhD

“…To the Editor: The identification of polymorphonuclear neutrophils as cellular source of cytokines prompts researchers in the field to investigate whether the…”
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CD66b−CD64dimCD115− cells in the human bone marrow represent neutrophil-committed progenitors by Calzetti, Federica, Finotti, Giulia, Tamassia, Nicola, Bianchetto-Aguilera, Francisco, Castellucci, Monica, Canè, Stefania, Lonardi, Silvia, Cavallini, Chiara, Matte, Alessandro, Gasperini, Sara, Signoretto, Ilaria, Benedetti, Fabio, Bonifacio, Massimiliano, Vermi, William, Ugel, Stefano, Bronte, Vincenzo, Tecchio, Cristina, Scapini, Patrizia, Cassatella, Marco A.

“…Here we report the identification of human CD66b − CD64 dim CD115 − neutrophil-committed progenitor cells (NCPs) within the SSC lo CD45 dim CD34 + and CD34…”
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The Long Non-coding RNA NRIR Drives IFN-Response in Monocytes: Implication for Systemic Sclerosis by Mariotti, Barbara, Servaas, Nila Hendrika, Rossato, Marzia, Tamassia, Nicola, Cassatella, Marco A, Cossu, Marta, Beretta, Lorenzo, van der Kroef, Maarten, Radstake, Timothy R D J, Bazzoni, Flavia

“…TLR4 activation initiates a signaling cascade leading to the production of type I IFNs and of the downstream IFN-stimulated genes (ISGs). Recently, a number of…”
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SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8 by Salvi, Valentina, Nguyen, Hoang Oanh, Sozio, Francesca, Schioppa, Tiziana, Gaudenzi, Carolina, Laffranchi, Mattia, Scapini, Patrizia, Passari, Mauro, Barbazza, Ilaria, Tiberio, Laura, Tamassia, Nicola, Garlanda, Cecilia, Del Prete, Annalisa, Cassatella, Marco A., Mantovani, Alberto, Sozzani, Silvano, Bosisio, Daniela

“…The inflammatory and IFN pathways of innate immunity play a key role in the resistance and pathogenesis of coronavirus disease 2019 (COVID-19). Innate sensors…”
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Toll‐Like Receptor‐3‐Activated Human Mesenchymal Stromal Cells Significantly Prolong the Survival and Function of Neutrophils by Cassatella, Marco A., Mosna, Federico, Micheletti, Alessandra, Lisi, Veronica, Tamassia, Nicola, Cont, Caterina, Calzetti, Federica, Pelletier, Martin, Pizzolo, Giovanni, Krampera, Mauro

“…Bone marrow‐derived mesenchymal stromal cells (BM‐MSCs) are stromal precursors endowed with extensive immunomodulative properties. In this study, we aimed to…”
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Understanding the molecular mechanisms of the multifaceted IL-10-mediated anti-inflammatory response: Lessons from neutrophils by Bazzoni, Flavia, Tamassia, Nicola, Rossato, Marzia, Cassatella, Marco A

“…Analysis of the molecular mechanisms governing the ability of IL-10 to keep inflammation under control has highlighted the existence of a great degree of…”
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Induction of OCT2 contributes to regulate the gene expression program in human neutrophils activated via TLR8 by Tamassia, Nicola, Bianchetto-Aguilera, Francisco, Gasperini, Sara, Polletti, Sara, Gardiman, Elisa, Ostuni, Renato, Natoli, Gioacchino, Cassatella, Marco A.

“…The transcription factors (TFs) that regulate inducible genes in activated neutrophils are not yet completely characterized. Herein, we show that the genomic…”
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CD14 + -Monocytes Exposed to Apolipoprotein CIII Express Tissue Factor by Olivieri, Oliviero, Gasperini, Sara, Calzetti, Federica, Gardiman, Elisa, Castagna, Annalisa, Martinelli, Nicola, Tamassia, Nicola, Cassatella, Marco A

“…Apolipoprotein CIII (ApoCIII) represents a key regulator of plasma lipid metabolism and a recognized risk factor for atherosclerosis and cardiovascular…”
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The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps by Jaillon, Sébastien, Peri, Giuseppe, Delneste, Yves, Frémaux, Isabelle, Doni, Andrea, Moalli, Federica, Garlanda, Cecilia, Romani, Luigina, Gascan, Hugues, Bellocchio, Silvia, Bozza, Silvia, Cassatella, Marco A, Jeannin, Pascale, Mantovani, Alberto

“…The long pentraxin (PTX) 3 is produced by macrophages and myeloid dendritic cells in response to Toll-like receptor agonists and represents a nonredundant…”
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