Does acute exposure to aldehydes impair pulmonary function and structure?

Highlights • As alcohol is used as fuel, the concentrations of aldehydes increase in air. • Acetaldehyde and formaldehyde are the most common aldehydes in ambient air. • Mice acutely breathed 3 concentrations of each aldehyde or 2 mixtures of them. • Lung mechanics and morphology, inflammatory and r...

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Published in:	Respiratory physiology & neurobiology Vol. 229; pp. 34 - 42
Main Authors:	Abreu, Mariana de, Neto, Alcendino Cândido, Carvalho, Giovanna, Casquillo, Natalia Vasconcelos, Carvalho, Niedja, Okuro, Renata, Ribeiro, Gabriel C.Motta, Machado, Mariana, Cardozo, Aléxia, Silva, Aline Santos e, Barboza, Thiago, Vasconcellos, Luiz Ricardo, Rodrigues, Danielle Araujo, Camilo, Luciana, Carneiro, Leticia de A.M, Jandre, Frederico, Pino, Alexandre V, Giannella-Neto, Antonio, Zin, Walter A, Corrêa, Leonardo Holanda Travassos, Souza, Marcio Nogueira de, Carvalho, Alysson R
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15-07-2016
Subjects:	Acetaldehyde Acetaldehyde - toxicity Air Pollutants - toxicity Air Pollution Animals Biomechanical Phenomena Female Formaldehyde Formaldehyde - toxicity Inflammation Lung - drug effects Lung - pathology Lung - physiopathology Lung mechanics Lung Volume Measurements Male Medical Education Mice, Inbred C57BL Models, Animal Morphology Nasal Mucosa - drug effects Nasal Mucosa - metabolism Nasal Mucosa - pathology Oxidative Stress - drug effects Oxidative Stress - physiology Pressure Pulmonary Ventilation Pulmonary/Respiratory Time Factors Volatile Organic Compounds - toxicity Air pollution formaldehyde acetaldehyde morphology inflammation lung mechanics Inflammation Morphology Formaldehyde Lung mechanics Acetaldehyde
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Summary:	Highlights • As alcohol is used as fuel, the concentrations of aldehydes increase in air. • Acetaldehyde and formaldehyde are the most common aldehydes in ambient air. • Mice acutely breathed 3 concentrations of each aldehyde or 2 mixtures of them. • Lung mechanics and morphology, inflammatory and redox markers were studied. • The exposed groups did not present any relevant difference relative to controls.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2016.04.002