Search Results - "Caspers, Michael"

Attitude toward second opinions in Germany - a survey of the general population by Könsgen, Nadja, Prediger, Barbara, Schlimbach, Anna, Bora, Ana-Mihaela, Hess, Simone, Caspers, Michael, Pieper, Dawid

“…Second medical opinions (SOs) can assist patients in making informed treatment decisions and improve the understanding of their diagnosis. In Germany, there…”
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Discovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening by Negri, Ana, Rives, Marie-Laure, Caspers, Michael J, Prisinzano, Thomas E, Javitch, Jonathan A, Filizola, Marta

“…Kappa-opioid (KOP) receptor agonists exhibit analgesic effects without activating reward pathways. In the search for nonaddictive opioid therapeutics and novel…”
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Systematic Screening of All Signal Peptides from Bacillus subtilis: A Powerful Strategy in Optimizing Heterologous Protein Secretion in Gram-positive Bacteria by Brockmeier, Ulf, Caspers, Michael, Freudl, Roland, Jockwer, Alexander, Noll, Thomas, Eggert, Thorsten

“…Efficient protein secretion is very important in biotechnology as it provides active and stable enzymes, which are an essential prerequisite for successful…”
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Predicting tracheostomy in multiple injured patients with severe thoracic injury (AIS ≥ 3) with the new T3P-Score: a multivariable regression prediction analysis by Bläsius, Felix M., Wutzler, Sebastian, Störmann, Philipp, Lustenberger, Thomas, Frink, Michael, Maegele, Marc, Weuster, Matthias, Bayer, Jörg, Horst, Klemens, Caspers, Michael, Seekamp, Andreas, Marzi, Ingo, Hildebrand, Frank, Andruszkow, Hagen

“…Multiple trauma patients with severe chest trauma are at increased risk for tracheostomy. While the risk factors associated with the need for tracheostomy are…”
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Plasmatic coagulation profile after major traumatic injury: a prospective observational study by Caspers, Michael, Schäfer, Nadine, Bouillon, Bertil, Schaeben, Victoria, Ciorba, Monica Christine, Maegele, Marc, Müller, Jens, Pötzsch, Bernd

“…Purpose Uncontrolled hemorrhage is still the major cause of preventable death after trauma and is aggravated by trauma-induced coagulopathy (TIC). The…”
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Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain by Caspers, Michael, Czogalla, Katrin J, Liphardt, Kerstin, Müller, Jens, Westhofen, Philipp, Watzka, Matthias, Oldenburg, Johannes

“…Abstract VKORC1 and VKORC1L1 are enzymes that both catalyze the reduction of vitamin K2,3-epoxide via vitamin K quinone to vitamin K hydroquinone. VKORC1 is…”
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Pneumonia in severely injured patients with thoracic trauma: results of a retrospective observational multi-centre study by Wutzler, Sebastian, Bläsius, Felix M, Störmann, Philipp, Lustenberger, Thomas, Frink, Michael, Maegele, Marc, Weuster, Matthias, Bayer, Jörg, Caspers, Michael, Seekamp, Andreas, Marzi, Ingo, Andruszkow, Hagen, Hildebrand, Frank

“…While the incidence and aspects of pneumonia in ICU patients has been extensively discussed in the literature, studies on the occurrence of pneumonia in…”
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Plasmatic and cell-based enhancement by microparticles originated from platelets and endothelial cells under simulated in vitro conditions of a dilutional coagulopathy by Böhm, Julia K, Schäfer, Nadine, Maegele, Marc, Stümpges, Birgit, Bauerfeind, Ursula, Caspers, Michael

“…Aggressive fluid management and other external factors may lead to hypothermia, acidosis and hemodilution (defined as Lethal Triad, LT) contributing to a…”
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How do external factors contribute to the hypocoagulative state in trauma-induced coagulopathy? – in vitro analysis of the lethal triad in trauma by Caspers, Michael, Schäfer, Nadine, Frölich, Matthias, Bauerfeind, Ursula, Bouillon, Bertil, Mutschler, Manuel, Maegele, Marc

“…Inneholder sammendrag…”
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Time course of pharmacokinetic and hormonal effects of inhaled high-dose salvinorin A in humans by Johnson, Matthew W, MacLean, Katherine A, Caspers, Michael J, Prisinzano, Thomas E, Griffiths, Roland R

“…Salvinorin A is a kappa opioid agonist and the principal psychoactive constituent of the Salvia divinorum plant, which has been used for hallucinogenic…”
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Temporal phenotyping of circulating microparticles after trauma: a prospective cohort study by Fröhlich, Matthias, Schäfer, Nadine, Caspers, Michael, Böhm, Julia K, Stürmer, Ewa K, Bouillon, Bertil, Maegele, Marc

“…After severe polytrauma the dynamic process of coagulation may deteriorate towards a trauma-induced coagulopathy (TIC) promoting a dramatic increase in…”
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Opioid Receptor Probes Derived from Cycloaddition of the Hallucinogen Natural Product Salvinorin A by Lozama, Anthony, Cunningham, Christopher W, Caspers, Michael J, Douglas, Justin T, Dersch, Christina M, Rothman, Richard B, Prisinzano, Thomas E

“…As part of our continuing efforts toward more fully understanding the structure−activity relationships of the neoclerodane diterpene salvinorin A, we report…”
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Changes in anaesthetic use for trauma patients in German HEMS - a retrospective study over a ten-year period by Wafaisade, Arasch, Caspers, Michael, Bouillon, Bertil, Helm, Matthias, Ruppert, Matthias, Gäßler, Michael

“…Airway management and use of intravenous anaesthetics to facilitate tracheal intubation after major trauma remains controversial. Numerous agents are available…”
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N-Acetyl-S-(N,N-diethylcarbamoyl) cysteine in rat nucleus accumbens, medial prefrontal cortex, and in rat and human plasma after disulfiram administration by Winefield, Robert D., Heemskerk, Anthonius A.M., Kaul, Swetha, Williams, Todd D., Caspers, Michael J., Prisinzano, Thomas E., McCance-Katz, Elinore F., Lunte, Craig E., Faiman, Morris D.

“…•Validation of a selective and sensitive HPLC–MS/MS assay for DETC-NAC is described.•DETC-NAC is confirmed as a metabolite of disulfiram.•Microdialysis studies…”
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Discovery, Structure Elucidation, and Biological Characterization of Nannocystin A, a Macrocyclic Myxobacterial Metabolite with Potent Antiproliferative Properties by Hoffmann, Holger, Kogler, Herbert, Heyse, Winfried, Matter, Hans, Caspers, Michael, Schummer, Dietmar, Klemke-Jahn, Christine, Bauer, Armin, Penarier, Geraldine, Debussche, Laurent, Brönstrup, Mark

“…Microbial natural products are a rich source of bioactive molecules to serve as drug leads and/or biological tools. We investigated a little‐explored…”
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Improvement of Sec-dependent secretion of a heterologous model protein in Bacillus subtilis by saturation mutagenesis of the N-domain of the AmyE signal peptide by Caspers, Michael, Brockmeier, Ulf, Degering, Christian, Eggert, Thorsten, Freudl, Roland

“…Due to the lack of an outer membrane, Gram-positive bacteria (e.g., Bacillus species) are considered as promising host organisms for the secretory production…”
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Global Coagulation Testing in Acute Care Medicine: Back to Bedside? by Caspers, Michael, Holle, Johannes Fabian, Limper, Ulrich, Fröhlich, Matthias, Bouillon, Bertil

“…Detailed and decisive information about the patients' coagulation status is important in various emergency situations. Conventional global coagulation testing…”
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Corynebacterium glutamicum possesses two secA homologous genes that are essential for viability by Caspers, Michael, Freudl, Roland

“…SecA is a central component of the bacterial Sec preprotein translocase. Besides the housekeeping SecA (SecA1), some mostly pathogenic Gram-positive bacteria…”
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Deficiencies of antithrombin, protein C and protein S - practical experience in genetic analysis of a large patient cohort by Caspers, Michael, Pavlova, Anna, Driesen, Julia, Harbrecht, Ursula, Klamroth, Robert, Kadar, Janos, Fischer, Ronald, Kemkes-Matthes, Bettina, Oldenburg, Johannes

“…Deficiencies of natural anticoagulant proteins including antithrombin (AT), protein C (PC) and protein S (PS) are important causes of inherited thrombophilia…”
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Is ROTEM Diagnostic in Trauma Care Associated with Lower Mortality Rates in Bleeding Patients?—A Retrospective Analysis of 7461 Patients Derived from the TraumaRegister DGU by Riehl, Katrin, Lefering, Rolf, Maegele, Marc, Caspers, Michael, Migliorini, Filippo, Schenker, Hanno, Hildebrand, Frank, Fröhlich, Matthias, Driessen, Arne

“…Introduction: Death from uncontrolled trauma haemorrhage and subsequent trauma-induced coagulopathy (TIC) is potentially preventable. Point-of-care devices…”
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