Search Results - "Caspers, J."

Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients[S] by Janssens, Michelle, van Smeden, Jeroen, Gooris, Gert S., Bras, Wim, Portale, Guiseppe, Caspers, Peter J., Vreeken, Rob J., Hankemeier, Thomas, Kezic, Sanja, Wolterbeek, Ron, Lavrijsen, Adriana P., Bouwstra, Joke A.

“…A hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corneum (SC), primarily ceramides, fatty acids, and cholesterol, are…”
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The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients by van Smeden, Jeroen, Janssens, Michelle, Kaye, Edward C. J., Caspers, Peter J., Lavrijsen, Adriana P., Vreeken, Rob J., Bouwstra, Joke A.

“…An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids – comprised of ceramides (CERs), free fatty…”
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Compact low loss and broadband hybrid plasmonic directional coupler by Alam, M Z, Caspers, J Niklas, Aitchison, J S, Mojahedi, M

“…We propose a novel broadband coupler for silicon photonics using a hybrid plasmonic waveguide section. The hybrid plasmonic waveguide is used to create an…”
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Improving clinical diagnosis of early-stage cutaneous melanoma based on Raman spectroscopy by P. Santos, Inês, van Doorn, Remco, Caspers, Peter J., Bakker Schut, Tom C., Barroso, Elisa M., Nijsten, Tamar E. C., Noordhoek Hegt, Vincent, Koljenović, Senada, Puppels, Gerwin J.

“…Background Clinical diagnosis of early melanoma (Breslow thickness less than 0.8 mm) is crucial to disease-free survival. However, it is subjective and can be…”
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Franz Cell Diffusion Testing and Quantitative Confocal Raman Spectroscopy: In Vitro-In Vivo Correlation by Iliopoulos, Fotis, Caspers, Peter J., Puppels, Gerwin J., Lane, Majella E.

“…Previously, we reported the use of Confocal Raman Spectroscopy (CRS) to investigate the topical delivery of actives and excipients. We have also correlated the…”
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In Vitro-In Vivo Correlation in Dermal Delivery: The Role of Excipients by Patel, Avnish, Iliopoulos, Fotis, Caspers, Peter J, Puppels, Gerwin J, Lane, Majella E

“…The composition of topical and transdermal formulations is known to determine the rate and the extent of drug delivery to and through the skin. However, to…”
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In Vivo Confocal Raman Microspectroscopy of the Skin: Noninvasive Determination of Molecular Concentration Profiles by Caspers, Peter J., Bruining, Hajo A., Puppels, Gerwin J., Lucassen, Gerald W., Carter, Elizabeth A.

“…Confocal Raman spectroscopy is introduced as a noninvasive in vivo optical method to measure molecular concentration profiles in the skin. It is shown how it…”
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Loss-of-Function Mutations in the Filaggrin Gene Lead to Reduced Level of Natural Moisturizing Factor in the Stratum Corneum by Kezic, Sanja, Kemperman, Patrick M.J.H., Koster, Ellen S., de Jongh, Cindy M., Thio, Hok Bing, Campbell, Linda E., Irvine, Alan D., McLean, Irwin W.H., Puppels, Gerwin J., Caspers, Peter J.

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Limits of Detection of Topically Applied Products in the Skin Using In Vivo Raman Spectroscopy by Nico, Cláudio, Bakker Schut, Tom C, Caspers, Peter J, Puppels, Gerwin J

“…We have developed a method to determine the limit of detection (LoD) for quantitative measurement of exogenous analytes in the outer layer of the human skin by…”
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Raman profiles of the stratum corneum define 3 filaggrin genotype–determined atopic dermatitis endophenotypes by O'Regan, Gráinne M., MRCPI, Kemperman, Patrick M.J.H., MD, Sandilands, Aileen, PhD, Chen, Huijia, MD, Campbell, Linda E., BSc, Kroboth, Karin, PhD, Watson, Rosemarie, MD, Rowland, Marion, MB, PhD, Puppels, Gerwin J., PhD, McLean, W.H. Irwin, DSc, FMedSci, Caspers, Peter J., PhD, Irvine, Alan D., MD, FRCPI

“…Background Filaggrin ( FLG ) has a central role in the pathogenesis of atopic dermatitis (AD). FLG is a complex repetitive gene; highly population-specific…”
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Lipid to protein ratio plays an important role in the skin barrier function in patients with atopic eczema by Janssens, M., van Smeden, J., Puppels, G.J., Lavrijsen, A.P.M., Caspers, P.J., Bouwstra, J.A.

“…Summary Background The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment…”
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Sensitive Skin: Assessment of the Skin Barrier Using Confocal Raman Microspectroscopy by Richters, Renée J H, Falcone, Denise, Uzunbajakava, Natallia E, Varghese, Babu, Caspers, Peter J, Puppels, Gerwin J, van Erp, Piet E J, van de Kerkhof, Peter C M

“…Sensitive skin (SS), a frequently reported condition in the Western world, has been suggested to be underlined by an impaired skin barrier. The aim of this…”
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Is the Depth of Invasion a Marker for Elective Neck Dissection in Early Oral Squamous Cell Carcinoma? by Aaboubout, Yassine, van der Toom, Quincy M, de Ridder, Maria A J, De Herdt, Maria J, van der Steen, Berdine, van Lanschot, Cornelia G F, Barroso, Elisa M, Nunes Soares, Maria R, Ten Hove, Ivo, Mast, Hetty, Smits, Roeland W H, Sewnaik, Aniel, Monserez, Dominiek A, Keereweer, Stijn, Caspers, Peter J, Baatenburg de Jong, Robert J, Bakker Schut, Tom C, Puppels, Gerwin J, Hardillo, José A, Koljenović, Senada

“…The depth of invasion (DOI) is considered an independent risk factor for occult lymph node metastasis in oral cavity squamous cell carcinoma (OCSCC). It is…”
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Determination of natural moisturizing factors in the skin: Raman microspectroscopy versus HPLC by Koppes, S. A., Kemperman, P., Van Tilburg, I., Calkoen-Kwa, F., Engebretsen, K. A., Puppels, G. J., Caspers, P. J., Kezic, S.

“…Background: Natural moisturizing factor (NMF) is used as genotypic and phenotypic biomarker in diagnostics. This study is a side-to-side comparison of two…”
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Iterative metal artefact reduction in CT: can dedicated algorithms improve image quality after spinal instrumentation? by Aissa, J, Thomas, C, Sawicki, L.M, Caspers, J, Kröpil, P, Antoch, G, Boos, J

“…Aim To investigate the value of dedicated computed tomography (CT) iterative metal artefact reduction (iMAR) algorithms in patients after spinal…”
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Discriminating Basal Cell Carcinoma from its Surrounding Tissue by Raman Spectroscopy by Bakker Schut, Tom C., Caspers, Peter J., Puppels, Gerwin J., Nijssen, Annieke, Heule, Freerk, Neumann, Martino H.A., Hayes, Donal P.

“…The objective of this in vitro study was to explore the applicability of Raman spectroscopy to distinguish basal cell carcinoma from its surrounding…”
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Depth profiling of Stratum corneum hydration in vivo: a comparison between conductance and confocal Raman spectroscopic measurements by Boncheva, Mila, De Sterke, Johanna, Caspers, Peter J., Puppels, Gerwin J.

“…:  The high‐frequency electrical conductance of tape‐stripped human skin in vivo can be used to evaluate the hydration profile of Stratum corneum (SC)…”
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Tissue characterization using high wave number Raman spectroscopy by Koljenović, S, Bakker Schut, T C, Wolthuis, R, de Jong, B, Santos, L, Caspers, P J, Kros, J M, Puppels, G J

“…Raman spectroscopy is a powerful diagnostic tool, enabling tissue identification and classification. Mostly, the so-called fingerprint (approximately 400-1800…”
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Raman spectroscopy with an integrated arrayed-waveguide grating by Ismail, N, Choo-Smith, L-P, Wörhoff, K, Driessen, A, Baclig, A C, Caspers, P J, Puppels, G J, de Ridder, R M, Pollnau, M

“…An integrated arrayed-waveguide grating fabricated in silicon-oxynitride technology is applied to Raman spectroscopy. After its validation by reproducing the…”
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Discriminating basal cell carcinoma from perilesional skin using high wave-number Raman spectroscopy by Nijssen, Annieke, Maquelin, Kees, Santos, Luis F, Caspers, Peter J, Bakker Schut, Tom C, den Hollander, Jan C, Neumann, Martino H A, Puppels, Gerwin J

“…An expanding body of literature suggests Raman spectroscopy is a promising tool for skin cancer diagnosis and in-vivo tumor border demarcation. The development…”
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