Search Results - "Casper, C"

Building the Neuronal Microtubule Cytoskeleton by Kapitein, Lukas C., Hoogenraad, Casper C.

“…Microtubules are one of the major cytoskeletal components of neurons, essential for many fundamental cellular and developmental processes, such as neuronal…”
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Actin in dendritic spines: connecting dynamics to function by Hotulainen, Pirta, Hoogenraad, Casper C

“…Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the postsynaptic part of most excitatory synapses and are major sites of…”
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Microtubule Minus-End-Targeting Proteins by Akhmanova, Anna, Hoogenraad, Casper C.

“…Microtubules are cytoskeletal filaments that are intrinsically polarized, with two structurally and functionally distinct ends, the plus end and the minus end…”
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The postsynaptic architecture of excitatory synapses: a more quantitative view by Sheng, Morgan, Hoogenraad, Casper C

“…Excitatory (glutamatergic) synapses in the mammalian brain are usually situated on dendritic spines, a postsynaptic microcompartment that also harbors…”
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TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites by van Spronsen, Myrrhe, Mikhaylova, Marina, Lipka, Joanna, Schlager, Max A., van den Heuvel, Dave J., Kuijpers, Marijn, Wulf, Phebe S., Keijzer, Nanda, Demmers, Jeroen, Kapitein, Lukas C., Jaarsma, Dick, Gerritsen, Hans C., Akhmanova, Anna, Hoogenraad, Casper C.

“…In neurons, the distinct molecular composition of axons and dendrites is established through polarized targeting mechanisms, but it is currently unclear how…”
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Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding by Hoogenraad, Casper C, Akhmanova, Anna

“…Transport of different intracellular cargoes along cytoskeleton filaments is essential for the morphogenesis and function of a broad variety of eukaryotic…”
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Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites by Lipka, Joanna, Kapitein, Lukas C, Jaworski, Jacek, Hoogenraad, Casper C

“…In neurons, the polarized distribution of vesicles and other cellular materials is established through molecular motors that steer selective transport between…”
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Optogenetic control of organelle transport and positioning by van Bergeijk, Petra, Adrian, Max, Hoogenraad, Casper C., Kapitein, Lukas C.

“…An optogenetic strategy allowing light-mediated recruitment of distinct cytoskeletal motor proteins to specific organelles is established; this technique…”
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Synapse Pathology in Psychiatric and Neurologic Disease by van Spronsen, Myrrhe, Hoogenraad, Casper C.

“…Inhibitory and excitatory synapses play a fundamental role in information processing in the brain. Excitatory synapses usually are situated on dendritic…”
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Microtubule Minus-End Stabilization by Polymerization-Driven CAMSAP Deposition by Jiang, Kai, Hua, Shasha, Mohan, Renu, Grigoriev, Ilya, Yau, Kah Wai, Liu, Qingyang, Katrukha, Eugene A., Altelaar, A.F. Maarten, Heck, Albert J.R., Hoogenraad, Casper C., Akhmanova, Anna

“…Microtubules are cytoskeletal polymers with two structurally and functionally distinct ends, the plus- and the minus-end. Here, we focus on the mechanisms…”
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Differentiation between Oppositely Oriented Microtubules Controls Polarized Neuronal Transport by Tas, Roderick P., Chazeau, Anaël, Cloin, Bas M.C., Lambers, Maaike L.A., Hoogenraad, Casper C., Kapitein, Lukas C.

“…Microtubules are essential for polarized transport in neurons, but how their organization guides motor proteins to axons or dendrites is unclear. Because…”
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Specific KIF1A–adaptor interactions control selective cargo recognition by Hummel, Jessica J.A., Hoogenraad, Casper C.

“…Intracellular transport in neurons is driven by molecular motors that carry many different cargos along cytoskeletal tracks in axons and dendrites. Identifying…”
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Molecular Pathway of Microtubule Organization at the Golgi Apparatus by Wu, Jingchao, de Heus, Cecilia, Liu, Qingyang, Bouchet, Benjamin P., Noordstra, Ivar, Jiang, Kai, Hua, Shasha, Martin, Maud, Yang, Chao, Grigoriev, Ilya, Katrukha, Eugene A., Altelaar, A.F. Maarten, Hoogenraad, Casper C., Qi, Robert Z., Klumperman, Judith, Akhmanova, Anna

“…The Golgi apparatus controls the formation of non-centrosomal microtubule arrays important for Golgi organization, polarized transport, cell motility, and cell…”
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Control of neuronal polarity and plasticity – a renaissance for microtubules? by Hoogenraad, Casper C, Bradke, Frank

“…Microtubules have been regarded as essential structures for stable neuronal morphology but new studies are highlighting their role in dynamic neuronal…”
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Effect of leaf type on browse selection by free-ranging goats in a southern African savanna by Nyamukanza, Casper C, Sebata, Allan

“…Broad- and fine-leaved woody species respond to seasonal changes from wet to dry season differently. For example, broad-leaved species shed their leaves…”
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Interleukin-17: A Social Cytokine by Hoogenraad, Casper C., Riol-Blanco, Lorena

“…Some children with autism spectrum disorder (ASD) show behavioral improvements when experiencing inflammation accompanied by fever; however, little is known…”
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Local mechanisms regulating selective cargo entry and long-range trafficking in axons by Gumy, Laura F, Hoogenraad, Casper C

“…•Axonal cargo entry depends on the presence of multiple subcompartments in the proximal axon.•Local mechanisms along the axon ensure the long-distance…”
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Which way to go? Cytoskeletal organization and polarized transport in neurons by Kapitein, Lukas C., Hoogenraad, Casper C.

“…To establish and maintain their polarized morphology, neurons employ active transport driven by cytoskeletal motor proteins to sort cargo between axons and…”
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Multiple layers of spatial regulation coordinate axonal cargo transport by Zahavi, Eitan Erez, Hoogenraad, Casper C.

“…Nerve axons are shaped similar to long electric wires to quickly transmit information from one end of the body to the other. To remain healthy and functional,…”
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Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization by Tortosa, Elena, Adolfs, Youri, Fukata, Masaki, Pasterkamp, R. Jeroen, Kapitein, Lukas C., Hoogenraad, Casper C.

“…Microtubule-associated proteins (MAPs) are main candidates to stabilize neuronal microtubules, playing an important role in establishing axon-dendrite…”
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