Search Results - "Caspary, Donald M."
-
1
Auditory thalamic circuits and GABAA receptor function: Putative mechanisms in tinnitus pathology
Published in Hearing research (01-06-2017)“…Tinnitus is defined as a phantom sound (ringing in the ears), and can significantly reduce the quality of life for those who suffer its effects. Ten to fifteen…”
Get full text
Journal Article -
2
Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system
Published in Journal of experimental biology (01-06-2008)“…Aging and acoustic trauma may result in partial peripheral deafferentation in the central auditory pathway of the mammalian brain. In accord with homeostatic…”
Get full text
Journal Article -
3
Diminished cortical inhibition in an aging mouse model of chronic tinnitus
Published in The Journal of neuroscience (14-11-2012)“…Flavoprotein autofluorescence imaging was used to examine auditory cortical synaptic responses in aged animals with behavioral evidence of tinnitus and hearing…”
Get full text
Journal Article -
4
Inhibitory neurotransmission in animal models of tinnitus: Maladaptive plasticity
Published in Hearing research (01-09-2011)“…Tinnitus is a phantom auditory sensation experienced by up to 14% of the United States population with a smaller percentage experiencing decreased quality of…”
Get full text
Journal Article -
5
Underlying mechanisms of tinnitus: review and clinical implications
Published in Journal of the American Academy of Audiology (01-01-2014)“…The study of tinnitus mechanisms has increased tenfold in the last decade. The common denominator for all of these studies is the goal of elucidating the…”
Get more information
Journal Article -
6
Top‐down or bottom up: decreased stimulus salience increases responses to predictable stimuli of auditory thalamic neurons
Published in The Journal of physiology (01-05-2019)“…Key points Temporal imprecision leads to deficits in the comprehension of signals in cluttered acoustic environments, and the elderly are shown to use…”
Get full text
Journal Article -
7
Presynaptic Neuronal Nicotinic Receptors Differentially Shape Select Inputs to Auditory Thalamus and Are Negatively Impacted by Aging
Published in The Journal of neuroscience (22-11-2017)“…Acetylcholine (ACh) is a potent neuromodulator capable of modifying patterns of acoustic information flow. In auditory cortex, cholinergic systems have been…”
Get full text
Journal Article -
8
Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma
Published in Journal of neuroscience research (15-08-2008)“…A longstanding hypothesis is that tinnitus, the perception of sound without an external acoustic source, is triggered by a distinctive pattern of cochlear hair…”
Get full text
Journal Article -
9
Desensitizing nicotinic agents normalize tinnitus-related inhibitory dysfunction in the auditory cortex and ameliorate behavioral evidence of tinnitus
Published in Frontiers in neuroscience (25-05-2023)“…Tinnitus impacts between 10-20% of the population. Individuals most troubled by their tinnitus have their attention bound to and are distracted by, their…”
Get full text
Journal Article -
10
Processing of broadband stimuli across A1 layers in young and aged rats
Published in Hearing research (01-06-2010)“…Presbycusis can be considered a slow age-related peripheral and central deterioration of auditory function which manifests itself as deficits in speech…”
Get full text
Journal Article -
11
Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus
Published in PloS one (26-01-2011)“…Neural inhibition plays an important role in auditory processing and attentional gating. Extrasynaptic GABA(A) receptors (GABA(A)R), containing α(4)and δ…”
Get full text
Journal Article -
12
Affects of Aging on Receptive Fields in Rat Primary Auditory Cortex Layer V Neurons
Published in Journal of neurophysiology (01-10-2005)“…1 Departments of Pharmacology and 2 Surgery, Southern Illinois University School of Medicine, Springfield, Illinois Submitted 8 April 2005; accepted in final…”
Get full text
Journal Article -
13
Auditory thalamic circuits and GABA A receptor function: Putative mechanisms in tinnitus pathology
Published in Hearing research (01-06-2017)“…Tinnitus is defined as a phantom sound (ringing in the ears), and can significantly reduce the quality of life for those who suffer its effects. Ten to fifteen…”
Get full text
Journal Article -
14
Single unit hyperactivity and bursting in the auditory thalamus of awake rats directly correlates with behavioural evidence of tinnitus
Published in The Journal of physiology (15-11-2014)“…Key points Medial geniculate body (MGB) single units recorded from sound‐exposed animals with behavioural evidence of tinnitus exhibits enhanced spontaneous…”
Get full text
Journal Article -
15
Ringing ears: the neuroscience of tinnitus
Published in The Journal of neuroscience (10-11-2010)“…Tinnitus is a phantom sound (ringing of the ears) that affects quality of life for millions around the world and is associated in most cases with hearing…”
Get full text
Journal Article -
16
Tinnitus-related increases in single-unit activity in awake rat auditory cortex correlate with tinnitus behavior
Published in Hearing research (01-04-2024)“…•Studied a condition suppression sound-exposure animal model of tinnitus.•A1 single units showed tinnitus-related increases in spontaneous and driven…”
Get full text
Journal Article -
17
Nicotinic Receptor Subunit Distribution in Auditory Cortex: Impact of Aging on Receptor Number and Function
Published in The Journal of neuroscience (22-07-2020)“…The presence of novel or degraded communication sounds likely results in activation of basal forebrain cholinergic neurons increasing release of ACh onto…”
Get full text
Journal Article -
18
Modulation of stimulus‐specific adaptation by GABAA receptor activation or blockade in the medial geniculate body of the anaesthetized rat
Published in The Journal of physiology (15-02-2014)“…Key points Neurons in the medial geniculate body (MGB), the auditory thalamus, give stronger responses to rare sounds than to repetitive sounds, a phenomenon…”
Get full text
Journal Article -
19
Modulation of stimulus-specific adaptation by GABA(A) receptor activation or blockade in the medial geniculate body of the anaesthetized rat
Published in The Journal of physiology (15-02-2014)“…Stimulus-specific adaptation (SSA), which describes adaptation to repeated sounds concurrent with the maintenance of responsiveness to uncommon ones, may be an…”
Get full text
Journal Article -
20
Corticothalamic projections deliver enhanced responses to medial geniculate body as a function of the temporal reliability of the stimulus
Published in The Journal of physiology (01-12-2021)“…Ageing and challenging signal‐in‐noise conditions are known to engage the use of cortical resources to help maintain speech understanding. Extensive…”
Get full text
Journal Article