Search Results - "Caspary, Donald M"

Auditory thalamic circuits and GABAA receptor function: Putative mechanisms in tinnitus pathology by Caspary, Donald M., Llano, Daniel A.

“…Tinnitus is defined as a phantom sound (ringing in the ears), and can significantly reduce the quality of life for those who suffer its effects. Ten to fifteen…”
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Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system by Caspary, Donald M, Ling, Lynne, Turner, Jeremy G, Hughes, Larry F

“…Aging and acoustic trauma may result in partial peripheral deafferentation in the central auditory pathway of the mammalian brain. In accord with homeostatic…”
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Diminished cortical inhibition in an aging mouse model of chronic tinnitus by Llano, Daniel A, Turner, Jeremy, Caspary, Donald M

“…Flavoprotein autofluorescence imaging was used to examine auditory cortical synaptic responses in aged animals with behavioral evidence of tinnitus and hearing…”
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Inhibitory neurotransmission in animal models of tinnitus: Maladaptive plasticity by Wang, Hongning, Brozoski, Thomas J., Caspary, Donald M.

“…Tinnitus is a phantom auditory sensation experienced by up to 14% of the United States population with a smaller percentage experiencing decreased quality of…”
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Underlying mechanisms of tinnitus: review and clinical implications by Henry, James A, Roberts, Larry E, Caspary, Donald M, Theodoroff, Sarah M, Salvi, Richard J

“…The study of tinnitus mechanisms has increased tenfold in the last decade. The common denominator for all of these studies is the goal of elucidating the…”
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Top‐down or bottom up: decreased stimulus salience increases responses to predictable stimuli of auditory thalamic neurons by Kommajosyula, Srinivasa P., Cai, Rui, Bartlett, Edward, Caspary, Donald M.

“…Key points Temporal imprecision leads to deficits in the comprehension of signals in cluttered acoustic environments, and the elderly are shown to use…”
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Presynaptic Neuronal Nicotinic Receptors Differentially Shape Select Inputs to Auditory Thalamus and Are Negatively Impacted by Aging by Sottile, Sarah Y, Hackett, Troy A, Cai, Rui, Ling, Lynne, Llano, Daniel A, Caspary, Donald M

“…Acetylcholine (ACh) is a potent neuromodulator capable of modifying patterns of acoustic information flow. In auditory cortex, cholinergic systems have been…”
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Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma by Bauer, Carol A., Turner, Jeremy G., Caspary, Donald M., Myers, Kristin S., Brozoski, Thomas J.

“…A longstanding hypothesis is that tinnitus, the perception of sound without an external acoustic source, is triggered by a distinctive pattern of cochlear hair…”
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Desensitizing nicotinic agents normalize tinnitus-related inhibitory dysfunction in the auditory cortex and ameliorate behavioral evidence of tinnitus by Ghimire, Madan, Cai, Rui, Ling, Lynne, Brownell, Kevin A, Wisner, Kurt W, Cox, Brandon C, Hackett, Troy A, Brozoski, Thomas J, Caspary, Donald M

“…Tinnitus impacts between 10-20% of the population. Individuals most troubled by their tinnitus have their attention bound to and are distracted by, their…”
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Processing of broadband stimuli across A1 layers in young and aged rats by Hughes, Larry F., Turner, Jeremy G., Parrish, Jennifer L., Caspary, Donald M.

“…Presbycusis can be considered a slow age-related peripheral and central deterioration of auditory function which manifests itself as deficits in speech…”
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Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus by Richardson, Ben D, Ling, Lynne L, Uteshev, Victor V, Caspary, Donald M

“…Neural inhibition plays an important role in auditory processing and attentional gating. Extrasynaptic GABA(A) receptors (GABA(A)R), containing α(4)and δ…”
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Affects of Aging on Receptive Fields in Rat Primary Auditory Cortex Layer V Neurons by Turner, Jeremy G, Hughes, Larry F, Caspary, Donald M

“…1 Departments of Pharmacology and 2 Surgery, Southern Illinois University School of Medicine, Springfield, Illinois Submitted 8 April 2005; accepted in final…”
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Auditory thalamic circuits and GABA A receptor function: Putative mechanisms in tinnitus pathology by Caspary, Donald M, Llano, Daniel A

“…Tinnitus is defined as a phantom sound (ringing in the ears), and can significantly reduce the quality of life for those who suffer its effects. Ten to fifteen…”
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Single unit hyperactivity and bursting in the auditory thalamus of awake rats directly correlates with behavioural evidence of tinnitus by Kalappa, Bopanna I., Brozoski, Thomas J., Turner, Jeremy G., Caspary, Donald M.

“…Key points Medial geniculate body (MGB) single units recorded from sound‐exposed animals with behavioural evidence of tinnitus exhibits enhanced spontaneous…”
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Ringing ears: the neuroscience of tinnitus by Roberts, Larry E, Eggermont, Jos J, Caspary, Donald M, Shore, Susan E, Melcher, Jennifer R, Kaltenbach, James A

“…Tinnitus is a phantom sound (ringing of the ears) that affects quality of life for millions around the world and is associated in most cases with hearing…”
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Tinnitus-related increases in single-unit activity in awake rat auditory cortex correlate with tinnitus behavior by Cai, Rui, Ling, Lynne, Ghimire, Madan, Brownell, Kevin A., Caspary, Donald M.

“…•Studied a condition suppression sound-exposure animal model of tinnitus.•A1 single units showed tinnitus-related increases in spontaneous and driven…”
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Nicotinic Receptor Subunit Distribution in Auditory Cortex: Impact of Aging on Receptor Number and Function by Ghimire, Madan, Cai, Rui, Ling, Lynne, Hackett, Troy A, Caspary, Donald M

“…The presence of novel or degraded communication sounds likely results in activation of basal forebrain cholinergic neurons increasing release of ACh onto…”
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Modulation of stimulus‐specific adaptation by GABAA receptor activation or blockade in the medial geniculate body of the anaesthetized rat by Duque, Daniel, Malmierca, Manuel S., Caspary, Donald M.

“…Key points Neurons in the medial geniculate body (MGB), the auditory thalamus, give stronger responses to rare sounds than to repetitive sounds, a phenomenon…”
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Modulation of stimulus-specific adaptation by GABA(A) receptor activation or blockade in the medial geniculate body of the anaesthetized rat by Duque, Daniel, Malmierca, Manuel S, Caspary, Donald M

“…Stimulus-specific adaptation (SSA), which describes adaptation to repeated sounds concurrent with the maintenance of responsiveness to uncommon ones, may be an…”
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Corticothalamic projections deliver enhanced responses to medial geniculate body as a function of the temporal reliability of the stimulus by Kommajosyula, Srinivasa P., Bartlett, Edward L., Cai, Rui, Ling, Lynne, Caspary, Donald M.

“…Ageing and challenging signal‐in‐noise conditions are known to engage the use of cortical resources to help maintain speech understanding. Extensive…”
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