Search Results - "Caspary, D."

Mechanisms of GABAergic and cholinergic neurotransmission in auditory thalamus: Impact of aging by Richardson, B.D., Sottile, S.Y., Caspary, D.M.

“…Age-related hearing loss is a complex disorder affecting a majority of the elderly population. As people age, speech understanding becomes a challenge…”
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Elevated Fusiform Cell Activity in the Dorsal Cochlear Nucleus of Chinchillas with Psychophysical Evidence of Tinnitus by Brozoski, T. J, Bauer, C. A, Caspary, D. M

“…Chinchillas with psychophysical evidence of chronic tinnitus were shown to have significantly elevated spontaneous activity and stimulus-evoked responses in…”
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Plasticity at glycinergic synapses in dorsal cochlear nucleus of rats with behavioral evidence of tinnitus by Wang, H, Brozoski, T.J, Turner, J.G, Ling, L, Parrish, J.L, Hughes, L.F, Caspary, D.M

“…Abstract Fifteen percent to 35% of the United States population experiences tinnitus, a subjective “ringing in the ears”. Up to 10% of those afflicted report…”
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GABAergic inhibition shapes SAM responses in rat auditory thalamus by Cai, R, Caspary, D.M

“…Highlights • Medial geniculate body shows emergent properties in its coding of modulated stimuli. • A delicate balance of tonic GABA and NMDA signaling…”
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Age-related loss of the GABA synthetic enzyme glutamic acid decarboxylase in rat primary auditory cortex by Ling, L.L., Hughes, L.F., Caspary, D.M.

“…Age-related changes within the auditory brainstem typically include alterations in inhibitory neurotransmission and coding mediated by GABA and glycinergic…”
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Ageing‐related changes in GABAergic inhibition in mouse auditory cortex, measured using in vitro flavoprotein autofluorescence imaging by Stebbings, K. A., Choi, H. W., Ravindra, A., Caspary, D. M., Turner, J. G., Llano, D. A.

“…Key points Ageing is associated with hearing loss and changes in GABAergic signalling in the auditory system. We tested whether GABAergic signalling in an…”
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Age-related changes in glycine receptor subunit composition and binding in dorsal cochlear nucleus by Wang, H, Turner, J.G, Ling, L, Parrish, J.L, Hughes, L.F, Caspary, D.M

“…Abstract Age-related hearing loss, presbycusis, can be thought of, in part, as a slow progressive peripheral deafferentation. Previous studies suggest that…”
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Aged-related loss of temporal processing: Altered responses to amplitude modulated tones in rat dorsal cochlear nucleus by Schatteman, T.A, Hughes, L.F, Caspary, D.M

“…Abstract Loss of temporal processing is characteristic of age-related loss of speech understanding observed in the elderly. Inhibitory glycinergic circuits…”
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GAD levels and muscimol binding in rat inferior colliculus following acoustic trauma by Milbrandt, J.C, Holder, T.M, Wilson, M.C, Salvi, R.J, Caspary, D.M

“…Pharmacological studies of the inferior colliculus (IC) suggest that the inhibitory amino acid neurotransmitter γ-aminobutyric acid (GABA) plays an important…”
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Gap Detection Deficits in Rats With Tinnitus: A Potential Novel Screening Tool by Turner, Jeremy G, Brozoski, Thomas J, Bauer, Carol A, Parrish, Jennifer L, Myers, Kristin, Hughes, Larry F, Caspary, Donald M

“…The study describes a novel method for tinnitus screening in rats by use of gap detection reflex procedures. The authors hypothesized that if a background…”
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GABA inputs control discharge rate primarily within frequency receptive fields of inferior colliculus neurons by Palombi, P S, Caspary, D M

“…1. Recent studies have suggested that gamma-aminobutyric acid (GABA) inputs shape monaural and binaural neuronal response properties in the central nucleus of…”
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Down-regulation of inhibition following unilateral deafening by Mossop, J.E., Wilson, M.J., Caspary, D.M., Moore, D.R.

“…Physiological and neurochemical experiments described here suggest that unilateral deafening causes a reduction in inhibition in the adult gerbil inferior…”
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Impact of sound exposure and aging on brain-derived neurotrophic factor and tyrosine kinase B receptors levels in dorsal cochlear nucleus 80 days following sound exposure by Wang, H, Brozoski, T.J, Ling, L, Hughes, L.F, Caspary, D.M

“…Abstract Recent studies suggested that acute sound exposure resulting in a temporary threshold shift in young adult animals within a series of maladaptive…”
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Effects of chronic salicylate on GABAergic activity in rat inferior colliculus by Bauer, C.A, Brozoski, T.J, Holder, T.M, Caspary, D.M

“…It is well accepted that salicylate ototoxicity results in reversible tinnitus in humans. Salicylate-induced tinnitus may be an example of plasticity of the…”
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Age-related changes in GABA A receptor subunit composition and function in rat auditory system by Caspary, D.M, Holder, T.M, Hughes, L.F, Milbrandt, J.C, McKernan, R.M, Naritoku, D.K

“…A decline in the ability to discriminate speech from noise due to age-related hearing loss (presbycusis) may reflect impaired auditory information processing…”
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Detection of glutamate decarboxylase isoforms in rat inferior colliculus following acoustic exposure by Abbott, S.D., Hughes, L.F., Bauer, C.A., Salvi, R., Caspary, D.M.

“…The inferior colliculus is a central auditory structure which serves as a site for the integration of ascending and descending auditory information. Changes in…”
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Inhibitory inputs modulate discharge rate within frequency receptive fields of anteroventral cochlear nucleus neurons by Caspary, D M, Backoff, P M, Finlayson, P G, Palombi, P S

“…1. The amino acid neurotransmitters gamma-aminobutyric acid (GABA) and glycine function as inhibitory neurotransmitters associated with nonprimary inputs onto…”
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Calorimetric detection of volatile organic compounds by Lerchner, J, Caspary, D, Wolf, G

“…A calorimetric sensor arrangement was developed to detect volatile organic compounds. The heat power which is generated by the sorption or desorption of the…”
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Physiology of the aged Fischer 344 rat inferior colliculus: responses to contralateral monaural stimuli by Palombi, P S, Caspary, D M

“…1. Presbycusis, age-related hearing loss, is an ever increasing problem in our aging society. It involves changes in both the peripheral and central portions…”
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Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis by Caspary, DM, Raza, A, Lawhorn Armour, BA, Pippin, J, Arneric, SP

“…The present study describes substantial, selective, age-related loss of the putative inhibitory neurotransmitter GABA in the central nucleus of the inferior…”
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