Autochthonous Transmission of East/Central/South African Genotype Chikungunya Virus, Brazil

We isolated East/Central/South African genotype chikungunya virus during the 2016 epidemic in Rio de Janeiro, Brazil. Genome sequencing revealed unique mutations in the nonstructural protein 4 (NSP4-A481D) and envelope protein 1 (E1-K211T). Moreover, all Brazil East/Central/South isolates shared the...

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Bibliographic Details
Published in:	Emerging infectious diseases Vol. 23; no. 10; pp. 1737 - 1739
Main Authors:	Cunha, Marcela S, Cruz, Nádia V G, Schnellrath, Laila C, Medaglia, Maria Luiza Gomes, Casotto, Michele E, Albano, Rodolpho M, Costa, Luciana J, Damaso, Clarissa R
Format:	Journal Article
Language:	English
Published:	United States U.S. National Center for Infectious Diseases 01-10-2017 Centers for Disease Control and Prevention
Subjects:	Adolescent Adult Aedes - virology Africa - epidemiology Analysis Animals arboviruses Autochthonous Transmission of East/Central/South African Genotype Chikungunya Virus, Brazil Brazil - epidemiology Cercopithecus aethiops Chikungunya Fever - epidemiology Chikungunya Fever - transmission Chikungunya Fever - virology Chikungunya virus Chikungunya virus - classification Chikungunya virus - genetics Chikungunya virus - isolation & purification dengue virus ECSA genotype Female Genetic aspects Genomes Genomics Genotype Humans Insect Vectors - virology Male Mosquitoes Phylogeny Proteins Research Letter RNA, Viral - genetics vector-borne infections Vero Cells Zika virus Brazil mosquitoes viruses ECSA genotype vector-borne infections Chikungunya virus arboviruses dengue virus Brazil alphaviruses Zika virus East/Central/South African Genotype
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Summary:	We isolated East/Central/South African genotype chikungunya virus during the 2016 epidemic in Rio de Janeiro, Brazil. Genome sequencing revealed unique mutations in the nonstructural protein 4 (NSP4-A481D) and envelope protein 1 (E1-K211T). Moreover, all Brazil East/Central/South isolates shared the exclusive mutations E1-M407L and E2-A103T.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2310.161855