Search Results - "Caskey, Marina"

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic by Caskey, Marina, Klein, Florian, Nussenzweig, Michel C.

“…Combination anti-retroviral therapy (ART) has revolutionized the treatment and prevention of HIV-1 infection. Taken daily, ART prevents and suppresses the…”
Get full text

Plasma Neutralization of the SARS-CoV-2 Omicron Variant by Schmidt, Fabian, Muecksch, Frauke, Weisblum, Yiska, Da Silva, Justin, Bednarski, Eva, Cho, Alice, Wang, Zijun, Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D

“…Neutralization assays of SARS-CoV-2 pseudoviruses expressing wild-type, omicron, or a synthetic resistant spike protein in plasma drawn from 47 people over…”
Get full text

Evolution of antibody immunity to SARS-CoV-2 by Gaebler, Christian, Wang, Zijun, Lorenzi, Julio C. C., Muecksch, Frauke, Finkin, Shlomo, Tokuyama, Minami, Cho, Alice, Jankovic, Mila, Schaefer-Babajew, Dennis, Oliveira, Thiago Y., Cipolla, Melissa, Viant, Charlotte, Barnes, Christopher O., Bram, Yaron, Breton, Gaëlle, Hägglöf, Thomas, Mendoza, Pilar, Hurley, Arlene, Turroja, Martina, Gordon, Kristie, Millard, Katrina G., Ramos, Victor, Schmidt, Fabian, Weisblum, Yiska, Jha, Divya, Tankelevich, Michael, Martinez-Delgado, Gustavo, Yee, Jim, Patel, Roshni, Dizon, Juan, Unson-O’Brien, Cecille, Shimeliovich, Irina, Robbiani, Davide F., Zhao, Zhen, Gazumyan, Anna, Schwartz, Robert E., Hatziioannou, Theodora, Bjorkman, Pamela J., Mehandru, Saurabh, Bieniasz, Paul D., Caskey, Marina, Nussenzweig, Michel C.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date…”
Get full text

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants by Wang, Zijun, Schmidt, Fabian, Weisblum, Yiska, Muecksch, Frauke, Barnes, Christopher O., Finkin, Shlomo, Schaefer-Babajew, Dennis, Cipolla, Melissa, Gaebler, Christian, Lieberman, Jenna A., Oliveira, Thiago Y., Yang, Zhi, Abernathy, Morgan E., Huey-Tubman, Kathryn E., Hurley, Arlene, Turroja, Martina, West, Kamille A., Gordon, Kristie, Millard, Katrina G., Ramos, Victor, Da Silva, Justin, Xu, Jianliang, Colbert, Robert A., Patel, Roshni, Dizon, Juan, Unson-O’Brien, Cecille, Shimeliovich, Irina, Gazumyan, Anna, Caskey, Marina, Bjorkman, Pamela J., Casellas, Rafael, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C.

“…Here we report on the antibody and memory B cell responses of a cohort of 20 volunteers who received the Moderna (mRNA-1273) or Pfizer–BioNTech (BNT162b2)…”
Get full text

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses by Schmidt, Fabian, Weisblum, Yiska, Muecksch, Frauke, Hoffmann, Hans-Heinrich, Michailidis, Eleftherios, Lorenzi, Julio C C, Mendoza, Pilar, Rutkowska, Magdalena, Bednarski, Eva, Gaebler, Christian, Agudelo, Marianna, Cho, Alice, Wang, Zijun, Gazumyan, Anna, Cipolla, Melissa, Caskey, Marina, Robbiani, Davide F, Nussenzweig, Michel C, Rice, Charles M, Hatziioannou, Theodora, Bieniasz, Paul D

“…The emergence of SARS-CoV-2 and the ensuing explosive epidemic of COVID-19 disease has generated a need for assays to rapidly and conveniently measure the…”
Get full text

High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape by Schmidt, Fabian, Weisblum, Yiska, Rutkowska, Magdalena, Poston, Daniel, DaSilva, Justin, Zhang, Fengwen, Bednarski, Eva, Cho, Alice, Schaefer-Babajew, Dennis J., Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C., Hatziioannou, Theodora, Bieniasz, Paul D.

“…The number and variability of the neutralizing epitopes targeted by polyclonal antibodies in individuals who are SARS-CoV-2 convalescent and vaccinated are key…”
Get full text

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection by Wang, Zijun, Muecksch, Frauke, Schaefer-Babajew, Dennis, Finkin, Shlomo, Viant, Charlotte, Gaebler, Christian, Hoffmann, Hans- Heinrich, Barnes, Christopher O., Cipolla, Melissa, Ramos, Victor, Oliveira, Thiago Y., Cho, Alice, Schmidt, Fabian, Da Silva, Justin, Bednarski, Eva, Aguado, Lauren, Yee, Jim, Daga, Mridushi, Turroja, Martina, Millard, Katrina G., Jankovic, Mila, Gazumyan, Anna, Zhao, Zhen, Rice, Charles M., Bieniasz, Paul D., Caskey, Marina, Hatziioannou, Theodora, Nussenzweig, Michel C.

“…More than one year after its inception, the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
Get full text

Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies by Barnes, Christopher O., West, Anthony P., Huey-Tubman, Kathryn E., Hoffmann, Magnus A.G., Sharaf, Naima G., Hoffman, Pauline R., Koranda, Nicholas, Gristick, Harry B., Gaebler, Christian, Muecksch, Frauke, Lorenzi, Julio C. Cetrulo, Finkin, Shlomo, Hägglöf, Thomas, Hurley, Arlene, Millard, Katrina G., Weisblum, Yiska, Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Caskey, Marina, Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal…”
Get full text

Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies by Greaney, Allison J., Starr, Tyler N., Barnes, Christopher O., Weisblum, Yiska, Schmidt, Fabian, Caskey, Marina, Gaebler, Christian, Cho, Alice, Agudelo, Marianna, Finkin, Shlomo, Wang, Zijun, Poston, Daniel, Muecksch, Frauke, Hatziioannou, Theodora, Bieniasz, Paul D., Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J., Bloom, Jesse D.

“…Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions…”
Get full text

Enhanced SARS-CoV-2 neutralization by dimeric IgA by Wang, Zijun, Lorenzi, Julio C C, Muecksch, Frauke, Finkin, Shlomo, Viant, Charlotte, Gaebler, Christian, Cipolla, Melissa, Hoffmann, Hans-Heinrich, Oliveira, Thiago Y, Oren, Deena A, Ramos, Victor, Nogueira, Lilian, Michailidis, Eleftherios, Robbiani, Davide F, Gazumyan, Anna, Rice, Charles M, Hatziioannou, Theodora, Bieniasz, Paul D, Caskey, Marina, Nussenzweig, Michel C

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), primarily infects cells at mucosal…”
Get more information

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants by Weisblum, Yiska, Schmidt, Fabian, Zhang, Fengwen, DaSilva, Justin, Poston, Daniel, Lorenzi, Julio Cc, Muecksch, Frauke, Rutkowska, Magdalena, Hoffmann, Hans-Heinrich, Michailidis, Eleftherios, Gaebler, Christian, Agudelo, Marianna, Cho, Alice, Wang, Zijun, Gazumyan, Anna, Cipolla, Melissa, Luchsinger, Larry, Hillyer, Christopher D, Caskey, Marina, Robbiani, Davide F, Rice, Charles M, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D

“…Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against…”
Get full text

Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost by Muecksch, Frauke, Wang, Zijun, Cho, Alice, Gaebler, Christian, Ben Tanfous, Tarek, DaSilva, Justin, Bednarski, Eva, Ramos, Victor, Zong, Shuai, Johnson, Brianna, Raspe, Raphael, Schaefer-Babajew, Dennis, Shimeliovich, Irina, Daga, Mridushi, Yao, Kai-Hui, Schmidt, Fabian, Millard, Katrina G., Turroja, Martina, Jankovic, Mila, Oliveira, Thiago Y., Gazumyan, Anna, Caskey, Marina, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C.

“…The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent individuals 1 – 3 . Despite the reduced protection from infection, individuals who…”
Get full text

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination by Cho, Alice, Muecksch, Frauke, Schaefer-Babajew, Dennis, Wang, Zijun, Finkin, Shlomo, Gaebler, Christian, Ramos, Victor, Cipolla, Melissa, Mendoza, Pilar, Agudelo, Marianna, Bednarski, Eva, DaSilva, Justin, Shimeliovich, Irina, Dizon, Juan, Daga, Mridushi, Millard, Katrina G., Turroja, Martina, Schmidt, Fabian, Zhang, Fengwen, Tanfous, Tarek Ben, Jankovic, Mila, Oliveria, Thiago Y., Gazumyan, Anna, Caskey, Marina, Bieniasz, Paul D., Hatziioannou, Theodora, Nussenzweig, Michel C.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces B cell responses that continue to evolve for at least a year. During that time,…”
Get full text

Persistent cellular immunity to SARS-CoV-2 infection by Breton, Gaëlle, Mendoza, Pilar, Hägglöf, Thomas, Oliveira, Thiago Y, Schaefer-Babajew, Dennis, Gaebler, Christian, Turroja, Martina, Hurley, Arlene, Caskey, Marina, Nussenzweig, Michel C

“…SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune…”
Get full text

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations by Muecksch, Frauke, Weisblum, Yiska, Barnes, Christopher O., Schmidt, Fabian, Schaefer-Babajew, Dennis, Wang, Zijun, C. Lorenzi, Julio C., Flyak, Andrew I., DeLaitsch, Andrew T., Huey-Tubman, Kathryn E., Hou, Shurong, Schiffer, Celia A., Gaebler, Christian, Da Silva, Justin, Poston, Daniel, Finkin, Shlomo, Cho, Alice, Cipolla, Melissa, Oliveira, Thiago Y., Millard, Katrina G., Ramos, Victor, Gazumyan, Anna, Rutkowska, Magdalena, Caskey, Marina, Nussenzweig, Michel C., Bjorkman, Pamela J., Hatziioannou, Theodora, Bieniasz, Paul D.

“…Antibodies elicited by infection accumulate somatic mutations in germinal centers that can increase affinity for cognate antigens. We analyzed 6 independent…”
Get full text

Enhanced clearance of HIV-1–infected cells by broadly neutralizing antibodies against HIV-1 in vivo by Lu, Ching-Lan, Murakowski, Dariusz K., Bournazos, Stylianos, Schoofs, Till, Sarkar, Debolina, Halper-Stromberg, Ariel, Horwitz, Joshua A., Nogueira, Lilian, Golijanin, Jovana, Gazumyan, Anna, Ravetch, Jeffrey V., Caskey, Marina, Chakraborty, Arup K., Nussenzweig, Michel C.

“…Antiretroviral drugs and antibodies limit HIV-1 infection by interfering with the viral life cycle. In addition, antibodies also have the potential to guide…”
Get full text

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals by Bar-On, Yotam, Gruell, Henning, Schoofs, Till, Pai, Joy A., Nogueira, Lilian, Butler, Allison L., Millard, Katrina, Lehmann, Clara, Suárez, Isabelle, Oliveira, Thiago Y., Karagounis, Theodora, Cohen, Yehuda Z., Wyen, Christoph, Scholten, Stefan, Handl, Lisa, Belblidia, Shiraz, Dizon, Juan P., Vehreschild, Jörg J., Witmer-Pack, Maggi, Shimeliovich, Irina, Jain, Kanika, Fiddike, Kerstin, Seaton, Kelly E., Yates, Nicole L., Horowitz, Jill, Gulick, Roy M., Pfeifer, Nico, Tomaras, Georgia D., Seaman, Michael S., Fätkenheuer, Gerd, Caskey, Marina, Klein, Florian, Nussenzweig, Michel C.

“…Monotherapy of HIV-1 infection with single antiretroviral agents is ineffective because error-prone HIV-1 replication leads to the production of drug-resistant…”
Get full text

Circulating precursors of human CD1c+ and CD141+ dendritic cells by Breton, Gaëlle, Lee, Jaeyop, Zhou, Yu Jerry, Schreiber, Joseph J, Keler, Tibor, Puhr, Sarah, Anandasabapathy, Niroshana, Schlesinger, Sarah, Caskey, Marina, Liu, Kang, Nussenzweig, Michel C

“…Two subsets of conventional dendritic cells (cDCs) with distinct cell surface markers and functions exist in mouse and human. The two subsets of cDCs are…”
Get full text

HIV-1 Integration Landscape during Latent and Active Infection by Cohn, Lillian B., Silva, Israel T., Oliveira, Thiago Y., Rosales, Rafael A., Parrish, Erica H., Learn, Gerald H., Hahn, Beatrice H., Czartoski, Julie L., McElrath, M. Juliana, Lehmann, Clara, Klein, Florian, Caskey, Marina, Walker, Bruce D., Siliciano, Janet D., Siliciano, Robert F., Jankovic, Mila, Nussenzweig, Michel C.

“…The barrier to curing HIV-1 is thought to reside primarily in CD4+ T cells containing silent proviruses. To characterize these latently infected cells, we…”
Get full text

Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico by Robbiani, Davide F., Bozzacco, Leonia, Keeffe, Jennifer R., Khouri, Ricardo, Olsen, Priscilla C., Gazumyan, Anna, Schaefer-Babajew, Dennis, Avila-Rios, Santiago, Nogueira, Lilian, Patel, Roshni, Azzopardi, Stephanie A., Uhl, Lion F.K., Saeed, Mohsan, Sevilla-Reyes, Edgar E., Agudelo, Marianna, Yao, Kai-Hui, Golijanin, Jovana, Gristick, Harry B., Lee, Yu E., Hurley, Arlene, Caskey, Marina, Pai, Joy, Oliveira, Thiago, Wunder, Elsio A., Sacramento, Gielson, Nery, Nivison, Orge, Cibele, Costa, Federico, Reis, Mitermayer G., Thomas, Neena M., Eisenreich, Thomas, Weinberger, Daniel M., de Almeida, Antonio R.P., West, Anthony P., Rice, Charles M., Bjorkman, Pamela J., Reyes-Teran, Gustavo, Ko, Albert I., MacDonald, Margaret R., Nussenzweig, Michel C.

“…Antibodies to Zika virus (ZIKV) can be protective. To examine the antibody response in individuals who develop high titers of anti-ZIKV antibodies, we screened…”
Get full text